Synchronous primary tumors of the female genital tract: a single center experience

Background: Primary synchronous cancer of the female genital tract is a relatively uncommon. Simultaneously detected endometrial and ovarian malignancies constitute the commonest occurrence. A set of pathological criteria has been described to differentiate synchronous primaries from metastatic tumors. The purpose of this study was to characterize patients with synchronous primary endometrial and ovarian tumors. Materials and Methods: This was a retrospective study done in Department of Pathology, Tribhuwan University Teaching Hospital from September 2006 to August 2011. The datas were retrieved from computer database. Results: There were totally of 10 cases of simultaneously detected endometrial and ovarian cancers. Out of 10 cases, 7 cases were synchronous primary endometrial and ovarian cancers while three were metastatic. Median age at presentation was 47.4 years. Six (85.8%) of these patients presenting with dual primary tumors were premenopausal. Grade 1 histology was seen in 57% of endometrial and 42% of ovarian tumors. Atypical endometrial hyperplasia was found in 42.8% of cases while none of the cases showed endometriosis. Conclusion: Though limited by relatively small number of cases, younger and premenopausal women were predisposed to developing synchronous primary tumors of the endometrium and ovary. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6019 JPN 2012; 2(3): 189-192

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Synchronous primary ovarian sex cord tumor and endometrial cancer

10.1055/s-0039-1685384 ◽

2016 ◽

Author(s):

S. A. Iqbal ◽

H. Shukla ◽

V. Jain ◽

S. Giri ◽

R. Sekhon ◽

...

Keyword(s):

Genital Tract ◽

Ovarian Tumor ◽

Early Stage ◽

Female Genital Tract ◽

Low Grade ◽

Primary Tumors ◽

Stromal Tumors ◽

Gynaecological Tumours ◽

Sex Cord Stromal Tumors ◽

Female Genital

Synchronous primary tumors of female genital tract are rare with a rate of about 0.7-1.8% of all gynaecological tumours. Most common primary tumours presenting as synchronous lesions are ovary and endometrium. However, sex cord stromal tumors are rare variety of primary ovarian tumor and synchronous with endometrium is even much rarer. These tumors are detected usually in younger, overweight, nulliparous and perimenopausal female. Synchronous primary tumors of endometrium and ovary have a better prognosis than the either of above alone because these are usually low grade and diagnosed at early stage. We present a report of four cases of synchronous endometrial and sex cord stromal tumors of ovary.

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Osteosarcoma of the Myometrium Synchronous with Bilateral Papillary Cystadenocarcinoma of the Ovary and Papillary Adenocarcinoma of the Cervix

Tumori Journal ◽

10.1177/030089168807400219 ◽

1988 ◽

Vol 74 (2) ◽

pp. 227-231 ◽

Cited By ~ 3

Author(s):

Fulvio Basolo ◽

Raffaele Pingitore ◽

Angelo Gadducci

Keyword(s):

Genital Tract ◽

Rare Case ◽

Female Genital Tract ◽

Papillary Adenocarcinoma ◽

Pathological Features ◽

Primary Tumors ◽

The World ◽

Clinical And Pathological Features ◽

Female Genital

We report an extremely rare case of a 60-year-old woman with myometrial osteosarcoma associated with bilateral papillary cystadenocarcinoma of the ovary and papillary adenocarcinoma of the cervix. The uterine osteosarcoma is the seventh case reported in the world, while it is the second case of syncronous triple primary tumors of the upper female genital tract. Clinical and pathological features of previously reported cases of uterine osteosarcoma and triple primary neoplasias of the upper female genital tract are critically reviewed.

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