Association between endometriosis and polymorphisms in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptor and osteoprotegerin genes and their serum levels

Abstract Background Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown pathophysiology with many proposed theories that involve CSF dynamics but recently, involvement of inflammatory and autoimmune processes has been postulated. Objectives To investigate presence of oligoclonal bands (OCB) in cerebrospinal fluid (CSF) and serum cytokine level in patients with IIH. Methods This study was conducted on 27 IIH female patients and 21 age- and sex-matched control groups. Patient and control groups were subjected to measurement of interleukin-4 (IL-4), IL-10, and tumor necrosis factor α (TNF-α) levels in serum, and CSF oligoclonal bands was measured in the IIH patient group. Body mass index (BMI) was measured to both patients and control. Results Serum levels of IL-4, IL-10, and TNF alpha were significantly higher in IIH patients than controls (p < 0.001); 22% of IIH patients had positive OCB in CSF. There was a statistically significant difference regarding TNF-α level in OCB-positive and OCB-negative patients being higher in positive patients. No statistically significant correlation was found between serum levels of IL-4, IL-10, TNF-α, and BMI. Conclusion Autoimmune inflammatory process may play a role in pathophysiology of IIH.

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Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study

Neurology Research International ◽

10.1155/2016/9060751 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

Mohammad Ali Ghaffari ◽

Elham Mousavinejad ◽

Forough Riahi ◽

Masoumeh Mousavinejad ◽

Mohammad Reza Afsharmanesh

Keyword(s):

Autism Spectrum Disorders ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Serum Levels ◽

Autism Spectrum ◽

Necrosis Factor Alpha ◽

Children With Asd ◽

Factor Alpha ◽

Spectrum Disorders ◽

Necrosis Factor

Background. Autism spectrum disorders (ASDs) are complex disorders where the pathogenesis is not fully understood. Several proinflammatory and immunoinflammatory disturbances have been observed in the etiology of ASD. There is, however, limited knowledge on variations of adipokines in ASD. The present study aimed to analyze the serum levels of resistin, visfatin, and tumor necrosis factor-alpha (TNF-α) in children with ASD in relation to body weight, gender, and ASD severity level. Method. In total, 30 children with ASD (mean age: 7.72±2.65 y; range; 4–12 y) and 30 healthy children (mean age: 8.4±2.66 y; range: 4–12 y), including males and females, were matched for age, gender, and body mass index (BMI). Serum samples were collected, and visfatin, resistin, and TNF-α serum levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit. Result. Serum visfatin, resistin, and TNF-α levels in children with ASD were significantly higher than that in the healthy patients (p<0.05). Two significant correlations were found: a correlation between resistin and visfatin with TNF-α in children with ASD (R = 0.8 and R = 0.62, resp.) and a correlation between resistin and visfatin in children with ASD (R = 0.66). Conclusion. Higher TNF-α, resistin, and visfatin levels were found in children with ASD in comparison with controls, suggesting that elevated levels of serum proinflammatory agents may be implicated in the pathophysiology of ASD.

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Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock.

Journal of Experimental Medicine ◽

10.1084/jem.173.6.1305 ◽

1991 ◽

Vol 173 (6) ◽

pp. 1305-1310 ◽

Cited By ~ 65

Author(s):

M Gadina ◽

R Bertini ◽

M Mengozzi ◽

M Zandalasini ◽

A Mantovani ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Actinomycin D ◽

Protective Action ◽

Endotoxic Shock ◽

Serum Levels ◽

Inhibitory Effect ◽

Protective Agent ◽

Initial Correlations ◽

Necrosis Factor

The present study was designed to define the potential of chlorpromazine (CPZ) as a protective agent against lipopolysaccharide (LPS) toxicity in comparison with glucocorticoids, and to obtain initial correlations with its effects on the levels of tumor necrosis factor (TNF), a pivotal mediator of endotoxic shock. It was found that CPZ protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and inhibited TNF serum levels, like dexamethasone (DEX), a well-known inhibitor of TNF synthesis. CPZ protected against LPS lethality when administered 30 minutes (min) before, simultaneously, or up to 10 min after LPS and was ineffective when given 30 min after LPS, paralleling the inhibitory effect on TNF production. In another experimental model, where mice were sensitized to LPS toxicity by actinomycin D, CPZ significantly inhibited LPS lethality and hepatotoxicity, whereas under these conditions DEX was inactive. These experiments indicate that CPZ has a protective action in both glucocorticoid-sensitive and -resistant models of endotoxic shock.

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Serum levels of tumor necrosis factor- in chronic inflammatory demyelinating polyneuropathy

Neurology ◽

10.1212/wnl.56.5.666 ◽

2001 ◽

Vol 56 (5) ◽

pp. 666-669 ◽

Cited By ~ 58

Author(s):

S. Misawa ◽

S. Kuwabara ◽

M. Mori ◽

N. Kawaguchi ◽

Y. Yoshiyama ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Chronic Inflammatory Demyelinating Polyneuropathy ◽

Serum Levels ◽

Demyelinating Polyneuropathy ◽

Inflammatory Demyelinating Polyneuropathy ◽

Necrosis Factor

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Expression of TNF-α, April and BCMA in Behcet’s Disease

Journal of Immunology Research ◽

10.1155/2014/380405 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Olfat G. Shaker ◽

Shereen O. Tawfic ◽

Amira M. El-Tawdy ◽

Mohamed H. M. El-Komy ◽

Manal El Menyawi ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

B Cell ◽

Behçet’S Disease ◽

Tumor Necrosis ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Serum Levels ◽

Behcet's Disease ◽

B Cell Activating Factor ◽

Necrosis Factor

Background. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet’s disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells.Objective. Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD.Patients and Methods. This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD. Twenty age-matched healthy male volunteers served as control. Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques.Results. The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner(P<0.001). Positive correlation was observed between hs-CRP and BDCAF (Behcet’s disease current activity forum) index (r0.68,P<0.001). None of the TNF family members tested was affected by a positive pathergy test.Conclusions. Patients have significantly higher levels of TNF family members’ (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD.

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Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis

Disease Markers ◽

10.1155/2014/541709 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Arzu Ataseven ◽

Recep Kesli ◽

Gulcan Saylam Kurtipek ◽

Perihan Ozturk

Keyword(s):

Uric Acid ◽

Tumor Necrosis Factor ◽

Interleukin 6 ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Receptor ◽

Severity Index ◽

Serum Levels ◽

Lipocalin 2 ◽

Pasi Score ◽

Necrosis Factor

Background. Chronic inflammation may play a role in psoriasis pathogenesis. Lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1 (sTNFR-1), interleukin-6, homocysteine, and uric acid are inflammatory and/or biochemical markers. However, both the roles of these markers and the pathogenesis of psoriasis are unknown.Objective. The aim of this study was to investigate serum levels of lipocalin 2, clusterin, sTNFR-1, interleukin-6, homocysteine, and uric acid in patients and controls groups.Methods. Fifty-six patients with psoriasis and 33 healthy controls were included in the study. Serum concentrations of the markers were evaluated by ELISA. The Psoriasis Area and Severity Index (PASI) was evaluated in all psoriasis patients. Body mass index (BMI) was calculated by dividing weight (kg) by height (m) squared.Results. The serum value of lipocalin and sTNFR-1 were significantly higher in psoriasis patients than in controls (resp.,P<0.001,P<0.05). The others showed no significant differences between psoriasis and the control groups (all of themP>0.05). The mean PASI score in the patient group was8.3±6.5.Conclusions. These findings suggest that lipocalin 2 and sTNFR-1 might play a role in the pathogenesis of psoriasis and can be used as markers of the disease.

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