Graft-versus-host disease in the female genital tract: a prospective cohort study

2021 ◽  
Author(s):  
Andréa Maria Novaes Machado ◽  
Morgani Rodrigues ◽  
Helena Malvezzi ◽  
Carla de Azevedo Piccinato ◽  
Nelson Hamerschlak ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Graft Versus Host Disease ◽  
Prospective Cohort ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Host Disease ◽  
Graft Versus Host ◽  
Female Genital

scholarly journals Female genital tract chronic graft-versus-host disease: A narrative review

2019 ◽  
Vol 41 (1) ◽  
pp. 69-75
Author(s):  
Andréa Maria Novaes Machado ◽  
Nelson Hamerschlak ◽  
Morgani Rodrigues ◽  
Carla de Azevedo Piccinato ◽  
Sergio Podgaec ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Narrative Review ◽  
Host Disease ◽  
Graft Versus Host ◽  
Female Genital

scholarly journals Chronic graft-versus-host disease: A prospective cohort study

2003 ◽  
Vol 9 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Mukta Arora, ◽  
Linda J. Burns, ◽  
Stella M. Davies, ◽  
Margaret L. MacMillan, ◽  
Todd E. Defor ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Graft Versus Host Disease ◽  
Prospective Cohort ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Female genital tract graft-versus-host disease: incidence, risk factors and recommendations for management

2006 ◽  
Vol 38 (8) ◽  
pp. 567-572 ◽  
Author(s):  
D Zantomio ◽  
A P Grigg ◽  
L MacGregor ◽  
Y Panek-Hudson ◽  
J Szer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Graft Versus Host Disease ◽  
Genital Tract ◽  
Disease Incidence ◽  
Female Genital Tract ◽  
Host Disease ◽  
Graft Versus Host ◽  
Incidence Risk ◽  
Female Genital

Female Genital Chronic Graft-Versus-Host Disease

2012 ◽  
Vol 93 (12) ◽  
pp. 1265-1269 ◽  
Author(s):  
Pierre Hirsch ◽  
Mathieu Leclerc ◽  
Michel Rybojad ◽  
Anna D. Petropoulou ◽  
Marie Robin ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Female Genital

Dry Eye Disease in Chronic Graft-Versus-Host Disease: Results From a Spanish Retrospective Cohort Study

2011 ◽  
Vol 43 (5) ◽  
pp. 1934-1938 ◽  
Author(s):  
P. de la Parra-Colín ◽  
A.L.D. Agahan ◽  
J.A. Pérez-Simón ◽  
A. López ◽  
D. Caballero ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dry Eye ◽  
Graft Versus Host Disease ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Ocular surface indicators and biomarkers in chronic ocular graft-versus-host disease: a prospective cohort study

2021 ◽  
Author(s):  
Alexandra A. Pietraszkiewicz ◽  
Debbie Payne ◽  
Maria Abraham ◽  
Angel Garced ◽  
Krishna C. Devarasetty ◽  
...  
Keyword(s):  
Cohort Study ◽  
Graft Versus Host Disease ◽  
Ocular Surface ◽  
Cell Transplant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Schirmer’S Test ◽  
Staining Score ◽  
Tnf Α ◽  
Corneal Staining

AbstractThis longitudinal cohort study compared ocular surface indicators in forty allogeneic hematopoietic stem cell transplant (HSCT) subjects with twenty healthy controls at baseline and identified changes in ocular graft-versus-host disease (oGVHD). Outcome measures included: Ocular Surface Disease Index (OSDI), tear osmolarity, Schirmer’s test, Oxford corneal staining score, tear break-up time (TBUT), and tear and serum biomarkers (IFN-γ, IL-10, MMP-9, IL-12, IL-13, IL-17α, IL-1β, IL-2, IL-4, IL-6, IL-8, CXCL10, MCP-1, MIP-1α, RANTES, TNF-α). At baseline the HSCT group had higher median Oxford corneal staining score (1.7 vs. 0.0; P < 0.0001), higher tear TNF-α (20.0 vs. 11.2 pg/mL; P < 0.0001), lower tear RANTES (70.4 vs. 190.2 pg/mL; P < 0.0001), higher serum IL-8 (10.2 vs. 4.5 pg/mL; P = 0.0008), and higher serum TNF-α (8.7 vs. 4.2 pg/mL; P < 0.0001). The incidence of oGVHD was 62% and associated changes included increased Oxford corneal staining score (4.6 vs. 1.8, P = 0.0001), decreased Schirmer’s test (3.0 vs. 10.0; P < 0.0001), and decreased TBUT (4.7 vs. 9.0 s; P = 0.0004). Baseline differences in ocular surface indicators suggest a tendency toward ocular dryness in individuals with hematologic disorders preparing for HSCT. Individuals who developed oGVHD showed changes in corneal staining score, Schirmer’s test, and TBUT.

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