scholarly journals Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study

2016 ◽  
Vol 16 (4) ◽  
pp. 441-448 ◽  
Author(s):  
Elizabeth H Byrne ◽  
Melis N Anahtar ◽  
Kathleen E Cohen ◽  
Amber Moodley ◽  
Nikita Padavattan ◽  
...  
Keyword(s):  
Cohort Study ◽  
South African ◽  
Target Cell ◽  
Genital Tract ◽  
Female Genital Tract ◽  
African Women ◽  
Cell Frequency ◽  
Hiv Acquisition ◽  
South African Women ◽  
Female Genital

scholarly journals Relationship between Receipt of a Social Protection Grant for a Child and Second Pregnancy Rates among South African Women: A Cohort Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137352 ◽  
Author(s):  
Molly Rosenberg ◽  
Audrey Pettifor ◽  
Nadia Nguyen ◽  
Daniel Westreich ◽  
Jacob Bor ◽  
...  
Keyword(s):  
Cohort Study ◽  
South African ◽  
Social Protection ◽  
Pregnancy Rates ◽  
African Women ◽  
South African Women

scholarly journals Comparison of Female Genital Tract Cytokine and Microbiota Signatures Induced by Initiation of Intramuscular DMPA and NET-EN Hormonal Contraceptives - a Prospective Cohort Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Smritee Dabee ◽  
Ramla F. Tanko ◽  
Bryan P. Brown ◽  
Rubina Bunjun ◽  
Christina Balle ◽  
...  
Keyword(s):  
High Risk ◽  
Genital Tract ◽  
Cohort Analysis ◽  
Female Genital Tract ◽  
Vaginal Microbiota ◽  
African Women ◽  
Hormonal Contraceptives ◽  
Rrna Gene ◽  
Female Genital

BackgroundCervicovaginal inflammation, bacterial microbiota and hormonal contraceptives all influence sexual and reproductive health. To date, the effects of intramuscular depo-medroxyprogesterone acetate (DMPA-IM) versus injectable norethisterone enanthate (NET-EN) on vaginal microbiota or cytokines have not been compared back-to-back, although in-vitro data suggest that DMPA-IM and NET-EN have different pharmacokinetic and biologic activities. This study aimed at comparing the effects of DMPA-IM versus NET-EN initiation on cervicovaginal cytokines and microbiota in women at high risk for sexually transmitted infections (STIs) assigned to the respective contraceptives.MethodsWe collected socio-demographic characteristics and vaginal samples from women initiating DMPA-IM (ECHO Trial; n = 53) and NET-EN (UChoose Trial; n = 44) at baseline and after two consecutive injections to assess cytokine concentrations by Luminex, vaginal microbiota by 16S rRNA gene sequencing, STIs, bacterial vaginosis (BV) and candidiasis.ResultsCytokine concentrations did not change significantly after initiating DMPA-IM or NET-EN, although NET-EN versus DMPA-IM-associated profiles were distinct. While the abundance of bacterial taxa associated with optimal and non-optimal microbiota fluctuated with DMPA-IM use, overall community composition did not significantly change with either contraceptive. HSV-2 serology, chlamydial infection, gonorrhoea and candidiasis did not influence the associations between contraceptive type and cervicovaginal cytokines or microbiota.ConclusionsBoth DMPA-IM and NET-EN use did not lead to broad inflammatory or microbiota changes in the female genital tract of sub-Saharan African women. This suggests that NET-EN is likely a viable option for contraception in African women at high risk of BV and STIs.

Graft-versus-host disease in the female genital tract: a prospective cohort study

2021 ◽  
Author(s):  
Andréa Maria Novaes Machado ◽  
Morgani Rodrigues ◽  
Helena Malvezzi ◽  
Carla de Azevedo Piccinato ◽  
Nelson Hamerschlak ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Graft Versus Host Disease ◽  
Prospective Cohort ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Host Disease ◽  
Graft Versus Host ◽  
Female Genital

scholarly journals Human Papillomavirus Seropositivity and Subsequent Risk of HIV Acquisition in Rural South African Women

2013 ◽  
Vol 40 (7) ◽  
pp. 601-606 ◽  
Author(s):  
Frank Tanser ◽  
Kyle G. Jones ◽  
Johannes Viljoen ◽  
John Imrie ◽  
Erofili Grapsa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
South African ◽  
African Women ◽  
Rural South ◽  
Hiv Acquisition ◽  
South African Women ◽  
Risk Of Hiv Acquisition ◽  
Subsequent Risk

Effects of Intra-vaginal Drying Agents on Mucosal Immune Activation and Risk for HIV Acquisition in South African Women

2014 ◽  
Vol 30 (S1) ◽  
pp. A230-A231
Author(s):  
Kathleen E. Doherty ◽  
Melis Anahtar ◽  
Musie Ghebremichael ◽  
Christina Thogabekale ◽  
Nikita Padavattan ◽  
...  
Keyword(s):  
South African ◽  
Immune Activation ◽  
African Women ◽  
Hiv Acquisition ◽  
South African Women

Metabolic Syndrome After HIV Acquisition in South African Women

2016 ◽  
Vol 73 (4) ◽  
pp. 438-445 ◽  
Author(s):  
Magdalena E. Sobieszczyk ◽  
Lise Werner ◽  
Koleka Mlisana ◽  
Nivashnee Naicker ◽  
Addi Feinstein ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
South African ◽  
African Women ◽  
Hiv Acquisition ◽  
South African Women

scholarly journals Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition

2020 ◽  
Vol 16 (12) ◽  
pp. e1009097
Author(s):  
Laura Noël-Romas ◽  
Michelle Perner ◽  
Refilwe Molatlhegi ◽  
Christina Farr Zuend ◽  
Amanda Mabhula ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Hormonal Contraceptive ◽  
Hormonal Contraceptives ◽  
Vaginal Microbiome ◽  
Hiv Susceptibility ◽  
Hiv Acquisition ◽  
Risk Of Hiv Acquisition ◽  
Microbiome Data ◽  
Female Genital

Alterations to the mucosal environment of the female genital tract, such as genital inflammation, have been associated with increased HIV acquisition in women. As the microbiome and hormonal contraceptives can affect vaginal mucosal immunity, we hypothesized these components may interact in the context of HIV susceptibility. Using previously published microbiome data from 685 women in the CAPRISA-004 trial, we compared relative risk of HIV acquisition in this cohort who were using injectable depot medroxyprogesterone acetate (DMPA), norethisterone enanthate (NET-EN), and combined oral contraceptives (COC). In women who were Lactobacillus-dominant, HIV acquisition was 3-fold higher in women using DMPA relative to women using NET-EN or COC (OR: 3.27; 95% CI: 1.24–11.24, P = 0.0305). This was not observed in non-Lactobacillus-dominant women (OR: 0.95, 95% CI: 0.44–2.15, P = 0.895) (interaction P = 0.0686). Higher serum MPA levels associated with increased molecular pathways of inflammation in the vaginal mucosal fluid of Lactobacillus-dominant women, but no differences were seen in non-Lactobacillus dominant women. This study provides data suggesting an interaction between the microbiome, hormonal contraceptives, and HIV susceptibility.

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