Short tone bursts are better than clicks for cervical vestibular-evoked myogenic potentials in clinical practice

2012 ◽  
Vol 269 (7) ◽  
pp. 1857-1863 ◽  
Author(s):  
David Viciana ◽  
Jose A. Lopez-Escamez
Keyword(s):  
Clinical Practice ◽  
Vestibular Evoked Myogenic Potentials ◽  
Better Than

scholarly journals Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
David B. Page ◽  
Harry Bear ◽  
Sangeetha Prabhakaran ◽  
Margaret E. Gatti-Mays ◽  
Alexandra Thomas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Clinical Practice ◽  
Clinical Data ◽  
Targeted Therapies ◽  
Metastatic Breast ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Better Than ◽  
Systemic Therapies

Abstract Antibodies blocking programmed death 1 (anti-PD-1) or its ligand (anti-PD-L1) are associated with modest response rates as monotherapy in metastatic breast cancer, but are generally well tolerated and capable of generating dramatic and durable benefit in a minority of patients. Anti-PD-1/L1 antibodies are also safe when administered in combination with a variety of systemic therapies (chemotherapy, targeted therapies), as well as with radiotherapy. We summarize preclinical, translational, and preliminary clinical data in support of combination approaches with anti-PD-1/L1 in metastatic breast cancer, focusing on potential mechanisms of synergy, and considerations for clinical practice and future investigation.

Ocular vestibular evoked myogenic potentials to air conduction (AC oVEMP): Useful in clinical practice?

2011 ◽  
Vol 65 (5) ◽  
pp. 333-338 ◽  
Author(s):  
L.E. Walther ◽  
M. Rogowski ◽  
K. Hörmann ◽  
H. Schaaf ◽  
J. Löhler
Keyword(s):  
Clinical Practice ◽  
Vestibular Evoked Myogenic Potentials ◽  
Air Conduction

scholarly journals An Evaluation and Dissemination Model for the Machine Learning Embedded System Lifecycle in Clinical Practice Settings

2021 ◽  
Author(s):  
melanie besculides ◽  
Ksenia Gorbenko ◽  
Cardinale Smith ◽  
Robert Freeman ◽  
David Reich ◽  
...  
Keyword(s):  
Machine Learning ◽  
Clinical Practice ◽  
Embedded System ◽  
Quantitative Methods ◽  
Clinical Decision Making ◽  
Comprehensive Evaluation ◽  
Healthcare Setting ◽  
Clinical Decision ◽  
Qualitative And Quantitative Methods ◽  
Better Than

Machine learning (ML) algorithms are gaining popularity in clinical practice settings due to their ability to process information in ways that augment human reasoning. While tools that rely on output from ML algorithms in the healthcare setting are appealing for their ability to aid in clinical decision making and streamline workflows, their implementation and effectiveness are not well documented. There is an abundance of published ML literature that focuses on whether algorithms can predict an outcome or predict it better than previous algorithms, but a dearth of effort evaluating their implementation or impact on patient outcomes. While developing and validating algorithms is an important first step in research, comprehensive evaluation is needed before application of ML algorithms in new settings is considered. Evaluation should examine both the process of implementation and the outcomes using a mix of qualitative and quantitative methods. This commentary describes a model we developed to guide our institutional ML evaluation efforts.

scholarly journals Transnasal Endoscopy is Preferred by Transoral Endoscopy Experienced Patients

2014 ◽  
Vol 23 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Abdurrahman Kadayifci ◽  
Mustafa Atar ◽  
Serap Parlar ◽  
Ayhan Balkan ◽  
Irfan Koruk ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Endoscopic Procedure ◽  
Upper Endoscopy ◽  
Transnasal Endoscopy ◽  
Post Procedure ◽  
Procedure Duration ◽  
Second Toe ◽  
Current Procedure ◽  
Better Than

Background & Aims: Both unsedated transoral endoscopy (TOE) and sedated TOE have some drawbacks in clinical practice. Unsedated transnasal endoscopy (TNE) has been suggested as an alternative to both methods. This study aimed to determine the advantages of TNE in patients who have previously undergone unsedated conventional TOE.Methods: Patients who had received an unsedated TOE in the last 12 months and were scheduled for a second upper endoscopy were included. They were randomized to undergo either unsedated TOE, using a standard endoscope, or unsedated TNE, using an ultrathin endoscope. Post-procedure, patients were asked to complete a questionnaire to assess pain, discomfort and acceptability of the procedure, and to compare the current procedure with their previous unsedated TOE. Endoscope insertion rate, procedure duration, and side-effects were recorded.Results: Each group included 50 patients. With the exception of nasal pain, the tolerability and acceptance were significantly greater in the unsedated TNE group. Significantly more TNE patients (82%) found the current endoscopic procedure to be better than their previous TOE when compared with patients who had received a second TOE (12%). A repeat procedure was significantly more acceptable for TNE patients when compared to the TOE group (68% vs.16%). The duration of endoscopy was significantly shorter in TOE than in TNE (p<0.05). Endoscope insertion failed in 4% and mild epistaxis was observed in 4% of TNE patients.Conclusion: Unsedated TNE was better tolerated in endoscopy experienced patients when compared with unsedated TOE. The majority of patients found TNE more acceptable and preferable to TOE, suggesting that TNE should become a more common practice in clinics when applicable.

scholarly journals The Predictive Value of the AQ and the SRS-A in the Diagnosis of ASD in Adults in Clinical Practice

2020 ◽  
Author(s):  
M. L. Bezemer ◽  
E. M. A. Blijd-Hoogewys ◽  
M. Meek-Heekelaar
Keyword(s):  
Clinical Practice ◽  
General Population ◽  
Predictive Value ◽  
Population Studies ◽  
Clinical Population ◽  
Patient Records ◽  
General Population Studies ◽  
Predictive Values ◽  
Better Than ◽  
Autism Assessment

Abstract Questionnaires are widely used in autism assessment. However, their psychometric properties are generally not evaluated in clinical practice, and the comparability and applicability of such research is limited because questionnaires are often not simultaneously evaluated. This certainly pertains to predictive values which are highly population and setting specific. This study evaluated the power of AQ and SRS-A in predicting an ASD diagnosis within the same clinical population. The patient records of 92 adults, referred for autism assessment, were analyzed. The AQ proved somewhat better than the SRS-A at discriminating and predicting autism. The predictive values of both questionnaires were lower than reported in general population studies. Psychometric results in core publications appear less representative for clinical practice.

scholarly journals Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng

2020 ◽  
Author(s):  
Mengyuan Peng ◽  
Yanlin Chen ◽  
Wenjuan Wang ◽  
Zhihua He ◽  
Wangqiang Dai ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Efficacy ◽  
Small Rna ◽  
High Throughput Sequencing ◽  
Differentially Expressed ◽  
Ancient Times ◽  
Differentially Expressed Mirna ◽  
The Difference ◽  
Wild Ginseng ◽  
Better Than

Abstract Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng, are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng, it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng. Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng.

New-Generation Pulse Oximetry in the Care of Critically Ill Patients

2005 ◽  
Vol 14 (1) ◽  
pp. 26-37 ◽  
Author(s):  
Karen K. Giuliano ◽  
Thomas L. Higgins
Keyword(s):  
Critical Care ◽  
Clinical Practice ◽  
Pulse Oximetry ◽  
Critically Ill Patients ◽  
Clinical Performance ◽  
Convincing Evidence ◽  
Generation Pulse ◽  
New Generation ◽  
Pulse Oximeters ◽  
Better Than

• Objective To review the published, peer-reviewed studies to date on use of the new-generation pulse oximeters, which are manufactured with algorithms to filter out patients’ body motions, and describe the application of new-generation pulse oximetry in clinical practice in critical care. • Methods MEDLINE was used to locate appropriate articles on pulse oximetry for the years 1995 to 2003. Each article was examined for scientific merit, content, and applicability to clinical practice. • Results A total of 17 relevant articles on the clinical performance of the new-generation pulse oximeters were reviewed, and the data were organized into a table. • Conclusions The combination of studies done in both clinical and laboratory settings did not provide any strong and convincing evidence that the performance of any single new-generation device was superior to that of any other new-generation device. However, the clinical performance of all the new-generation pulse oximetry devices was better than that of earlier devices.

scholarly journals Exercise dose in clinical practice: Right is better than more

2018 ◽  
Vol 25 (2) ◽  
pp. 287-288 ◽  
Author(s):  
Massimo Leggio ◽  
Maria Grazia Bendini ◽  
Stefania D’Emidio ◽  
Elisa Caldarone ◽  
Mario Lombardi ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Exercise Dose ◽  
Better Than

scholarly journals The constrictor knot is the best ligature

2014 ◽  
Vol 96 (2) ◽  
pp. 101-105 ◽  
Author(s):  
H Taylor ◽  
AW Grogono
Keyword(s):  
Clinical Practice ◽  
Test Bench ◽  
Suture Material ◽  
Invasive Procedures ◽  
Suture Materials ◽  
Surgical Practice ◽  
Linear Relationships ◽  
Surrogate Measurement ◽  
Better Than

Introduction An ideal ligature should tighten readily and remain tight. Ligature failure can be a critical complication of invasive procedures in human and veterinary surgical practice. Previous studies have tested various knots but not the constrictor knot. Methods A new test bench was employed to compare six ligatures using four suture materials. As tension in a ligature is not readily measured, the study employed a surrogate measurement: the force required to slide a ligature along a rod. Benchmark values tested each suture material wrapped around the rod to establish the ratio between this force and the ligature tension for each material. Each ligature was tested first during tightening and then again afterwards. The benchmark ratios were employed to calculate the tensions to evaluate which ligature and which suture material retained tension best. Results The model provided consistent linear relationships between the tension in the suture and the force required to pull the ligature along the rod. The constrictor knot retained tension in the ligature best (55–107% better than the next best ligature). Among the suture materials, polydioxanone had the greatest ability to retain the tension in a ligature and polyglactin the least. Conclusions The constrictor knot showed superior characteristics for use as a ligature, and should be introduced into teaching and clinical practice for human and veterinary surgery. The new test bench is recommended for future testing of ligatures as well as objective comparison of suture materials.

scholarly journals Reframing placebo in research and practice

2011 ◽  
Vol 366 (1572) ◽  
pp. 1896-1904 ◽  
Author(s):  
Wayne B. Jonas
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Clinical Practice ◽  
Evidence Based ◽  
Low Back ◽  
Placebo Effects ◽  
Clinical Practices ◽  
Research And Practice ◽  
Healing Environment ◽  
Better Than

The terms ‘placebo’ and ‘placebo effects’ cause confusion among patients, practitioners and scientists. This confusion results in both the adoption of practices that have no evidence of specificity yet considerable risk (such as surgery for low back pain) or the elimination of clinical practices proven to facilitate healing because they are not ‘better than placebo’ (such as acupuncture for low back pain). In this article, I discuss these issues and introduce the concept of optimal healing environment as a framework for disentangling what is useful from placebo research for adopting into clinical practice in a manner that is ethical and evidence-based.

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