scholarly journals Tinnitus in patients with hearing loss due to mitochondrial DNA pathogenic variants

2018 ◽  
Vol 275 (8) ◽  
pp. 1979-1985 ◽  
Author(s):  
Urszula Lechowicz ◽  
Agnieszka Pollak ◽  
Danuta Raj-Koziak ◽  
Beata Dziendziel ◽  
Piotr Henryk Skarżyński ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mitochondrial Dna ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Medical Problem ◽  
Polish Population ◽  
Pathogenic Variants ◽  
Individual Perception ◽  
Characteristic Features ◽  
Mtdna Variants

Abstract Purpose Tinnitus described as individual perception of phantom sound constitutes a significant medical problem and has become an essential subject of many studies conducted worldwide. In the study, we aimed to examine the prevalence of tinnitus among Polish hearing loss (HL) patients with identified mitochondrial DNA (mtDNA) variants. Methods Among the selected group of unrelated HL patients with known mtDNA pathogenic variants, two questionnaires were conducted, i.e. Tinnitus Handicap Inventory translated into Polish (THI-POL) and Visual Analogue Scale (VAS) for measuring subjectively perceived tinnitus loudness, distress, annoyance and possibility of coping with this condition (VASs). Pathogenic mtDNA variants were detected with real-time PCR and sequencing of the whole mtDNA. Results This is the first extensive tinnitus characterization using THI-POL and VASs questionnaires in HL patients due to mtDNA variants. We have established the prevalence of tinnitus among the studied group at 23.5%. We found that there are no statistically significant differences in the prevalence of tinnitus and its characteristic features between HL patients with known HL mtDNA variants and the general Polish population. In Polish HL patients with tinnitus, m.7511T>C was significantly more frequent than in patients without tinnitus. We observed that the prevalence of tinnitus is lower in Polish patients with m.1555A>G as compared to other available data. Conclusions Our data suggest that the mtDNA variants causative of HL may affect tinnitus development but this effect seems to be ethnic-specific.

scholarly journals Is There a Relationship Between Audiogram Shape and the Intensity and Duration of Tinnitus?

2018 ◽  
Vol 19 (3) ◽  
pp. 237-242
Author(s):  
Miroljub Trifunovic ◽  
Ljubica Zivic ◽  
Marija Draskovic ◽  
Milena Corbic ◽  
Jasmina Sretenovic
Keyword(s):  
Hearing Loss ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Case Series ◽  
Chronic Tinnitus ◽  
Low Frequencies ◽  
High Frequencies ◽  
Range Edge ◽  
Case Series Study ◽  
Patient Reported

Abstract Chronic tinnitus is often associated with hearing impairment, but it cannot be asserted that only hearing loss causes tinnitus. Audiograms of patients with tinnitus show that hearing loss occurred more often at high frequencies than at low frequencies. The aim of this study was to analyse the audiogram shapes of patients with chronic tinnitus and to identify the relationship between the shape of the audiogram and intensity and duration of tinnitus. This investigation was a cross case series study conducted at a general hospital in Kraljevo on patients with chronic subjective tinnitus. The study included 43 patients of both genders and of different ages. We used audiometry (measuring the threshold of hearing for frequencies from 250, 500, 1000, 2000, 4000 and 8000 Hz) and tympanometry. Each patient reported the intensity of tinnitus in each ear on a visual analogue scale (VAS1) and stated the duration of tinnitus for each ear. Our research showed that patients with chronic tinnitus had a characteristic audiogram with progressive hearing loss to high frequencies. Th is difference was significantly increased starting from lower to higher frequencies, and the most hearing-decreased range (“edge”) was between 2000 and 4000 Hz. We did not find a strong link between the tinnitus intensity measured by the visual analogue scale and tinnitus duration on one side and hearing loss in the studied patients and audiogram shape on the other side. The duration of tinnitus was most associated with hearing loss at 2000 Hertz, but even that was not significant.

scholarly journals Ancient mitochondrial DNA pathogenic variants putatively associated with mitochondrial disease

2020 ◽  
Author(s):  
Draga Toncheva ◽  
Dimitar Serbezov ◽  
Sena Karachanak-Yankova ◽  
Desislava Nesheva
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Disease ◽  
Novel Mutation ◽  
Mitochondrial Diseases ◽  
Type Model ◽  
Human Populations ◽  
Neolithic Period ◽  
Pathogenic Variants ◽  
Pathogenic Effect ◽  
Mtdna Variants

AbstractMitochondrial DNA variants associated with diseases are widely studied in contemporary populations, but their prevalence has not yet been investigated in ancient populations. The publicly available AmtDB database contains 1443 ancient mtDNA Eurasian genomes from different periods. The objective of this study was to use this data to establish the presence of pathogenic mtDNA variants putatively associated with mitochondrial diseases in ancient populations. The clinical significance, pathogenicity prediction and contemporary frequency of mtDNA variants were determined using online platforms. The analyzed ancient mtDNAs contain six variants designated as being “confirmed pathogenic” in modern patients. The oldest of these, m.7510T>C in the MT-TS1 gene, was found in a sample from the Neolithic period dated 5800-5400 BCE. All six have well established clinical association, and their pathogenic effect is corroborated by very low population frequencies in contemporary populations. In addition, ten variants designated as possibly or likely pathogenic were detected. The oldest of these were two variants in the MT-TD gene, m.7543A>G and m.7554G>A, from Neolithic samples dated 8205-7700 BCE. A novel mutation in contemporary populations, m.4440G>A in the MT-TM gene, is established in 12 ancient mtDNA samples from different periods ranging from 2800 BCE to 920 CE. The pathogenic effect of these possibly/likely pathogenic mutations is not yet well established, and further research is warranted. All detected mutations putatively associated with mitochondrial disease in ancient mtDNA samples are in tRNA coding genes. Most of these mutations are in a mt-tRNA type (Model 2) that is characterized by loss of D-loop/T-loop interaction. Seven mutations are located in CS-Anticodon stem, 4 are located in AS-Acceptor stem, 2 in TS-TΨC stem, and single mutations are found in DL-Dihydrouridine Loop, CL-Anticodon Loop and DS-Dihydrouridine stem. Exposing pathogenic variants in ancient human populations expands our understanding of their origin.

Intoxication Perception Visual Analogue Scale

2010 ◽  
Author(s):  
Jennifer R. Cromer ◽  
Jason A. Cromer ◽  
Paul Maruff ◽  
Peter J. Snyder
Keyword(s):  
Visual Analogue Scale ◽  
Analogue Scale

EFEKTIFITAS PENGGUNAAN TERAPI TRANSCUTANEUS ELECTRICAL NERVE STIMULATION (TENS) PADA PASIEN NYERI PUNGGUNG BAWAH DI RSUD dr. M HAULUSSY AMBON

2018 ◽  
pp. 70-78
Author(s):  
Ninik Maathia Sallatalohy ◽  
Mauren J Paliyama ◽  
Farah Ch Noya
Keyword(s):  
Visual Analogue Scale ◽  
Nerve Stimulation ◽  
Analogue Scale ◽  
Electrical Nerve Stimulation

Pendahuluan. Nyeri Punggung Bawah (NPB) merupakan suatu permasalahan yang paling sering ditemukan di masyarakat. Etiologinya tergolong kompleks dan dapat disebabkan oleh berbagai hal. Salah satu pilihan penatalaksanaan NPB adalah dengan terapi TENS. Tujuan. Tujuan penelitian ini adalah untuk mengetahui efektifitas terapi TENS pada pasien NPB di RSUD dr. M Haulussy Ambon. Metode. Desain penelitian yang digunakan adalah pretest–posttest design, dengan mengukur skala Visual Analogue Scale (VAS) sebelum dan setelah 5 kali terapi TENS. Jumlah subjek yang memenuhi kriteria sebanyak 71 dengan perbandingan laki-laki dan perempuan adalah 1:2. Hasil. Hasil uji Marginal Homogenity memperlihatkan perbedaan signifikansi sebelum dan setelah 5 kali terapi TENS (p = 0,000). Kesimpulan. TENS efektif dalam meredakan nyeri pada pasien NPB. Kata Kunci: Nyeri Punggung Bawah, TENS

A Novel Virtual Reality Technique (Cervigame®) Compared to Conventional Proprioceptive Training to Treat Neck Pain: A Randomized Controlled Trial

2019 ◽  
Vol 9 (3Jun) ◽  
Author(s):  
I Rezaei ◽  
M Razeghi ◽  
S Ebrahimi ◽  
S Kayedi ◽  
A Rezaeian Zadeh
Keyword(s):  
Virtual Reality ◽  
Visual Analogue Scale ◽  
Neck Pain ◽  
Analogue Scale ◽  
Controlled Trial ◽  
Neck Disability Index ◽  
Repeated Measure ◽  
Balance Test ◽  
Proprioceptive Training ◽  
Neck Disability

Background: Despite the potential benefits of virtual reality technology in physical rehabilitation, only a few studies have evaluated the efficacy of this type of treatment in patients with neck pain.Objective: The aim of this study was to compare the effects of virtual reality training (VRT) versus conventional proprioceptive training (CPT) in patients with neck pain.Methods: Forty four participants with nonspecific chronic neck pain were randomly assigned to VRT or CPT in this assessor-blinded clinical trial. A novel videogame called Cervigame® was designed for VRT. It comprises of 50 stages divided into unidirectional and two-directional stages ordered from easy to hard. CPT consisted of eye-follow, gaze stability, eye-head coordination and position and movement sense training. Both groups completed 8 training sessions over 4 weeks. Visual analogue scale score, neck disability index and Y-balance test results were recorded at baseline, immediately after and 5 weeks post-intervention. Mixed repeated measure ANOVA was used to analyze differences between mean values for each variable at an alpha level of 0.05.Results: There were significant improvements in all variables in both groups immediately after and 5 weeks after the intervention. Greater improvements were observed in the visual analogue scale and neck disability index scores in VRT group, and the results for all directions in Y-balance test were similar in both groups. No side effects were reported.Conclusion: Improvements in neck pain and disability were greater in VRT than CPT group. Cervigame® is a potentially practical tool for rehabilitation in patients with neck pain.

Depression, pain, and site:

1999 ◽  
Vol 15 (1) ◽  
pp. 10-17
Author(s):  
Molina Omar Franklin ◽  
Tavares Gimenes Pablo ◽  
Aquilino Raphael ◽  
Rank Rise ◽  
Coelho Santos Zeila ◽  
...  
Keyword(s):  
Visual Analogue Scale ◽  
Beck Depression Inventory ◽  
Temporomandibular Disorders ◽  
Analogue Scale ◽  
Epidemiological Data ◽  
Depression Severity ◽  
Internal Joint ◽  
The Difference ◽  
Biomechanical Tests

Objective: To assess the level of depression, severity of pain and pain in single/multiple sites in patients with different severity of bruxing behavior and Temporomandibular Disorders (TMDs). Methods: We evaluated 131 patients with bruxism and TMDs: 20 patients with mild bruxism, 42 patients with moderate bruxism, 45 patients with severe bruxism and 24 patients with extreme bruxism. We used the Beck Depression Inventory (BDI), clinical examination, a questionnaire of clinical epidemiological data, criteria for TMDs and bruxism, palpation of muscles and joints, the Visual Analogue Scale for pain, classification of the occlusion and biomechanical tests to assess for internal joint derangements. Results: The level of depression increased from the mild, to the moderate, severe and extreme bruxing behavior groups, but the difference was significant only from the mild to the extreme group (p<0.001). Pain levels increased from the mild and moderate to the severe and extreme subgroups, but were not statistically significant. Mean number of pain sites increased from the mild, to the moderate, severe and extreme subgroup and the difference was extremely significant (p<0.0001). Conclusion: Levels of depression, severity of pain and pain sites increased with severity of bruxing behavior. A higher number of pain sites with more severe bruxism indicates somatization in bruxers, but a further study using the same protocol and a psychological test for somatization would be indicated to further substantiate these findings.

EFFICACY OF TRANSVERSUS ABDOMINIS PLANE BLOCK FOR POST CESAREAN DELIVERY ANALGESIA

2018 ◽  
Vol 8 (5) ◽  
pp. 37-41
Author(s):  
Minh Nguyen Van ◽  
Nga Bui Thi Thuy ◽  
Thinh Tran Xuan
Keyword(s):  
Caesarean Section ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Transversus Abdominis Plane Block ◽  
Transversus Abdominis ◽  
Morphine Consumption ◽  
Block Group ◽  
Tap Block ◽  
Transversus Abdominis Plane ◽  
Pain Scores

Background: The transversus abdominis plane block (TAP block), a regional block, provides effective analgesia after lower abdominal surgeries. The objective of this study was to assess whether transversus abdominis plane block is effective as part of multimodal pain management following Cesarean section. Materials and Method: Totally, 60 ASA I and II parturients for Cesarean section via Pfannenstiel incision under spinal anesthesia were randomly allocated to either the TAP block group or the control. The TAP block group received a landmark-orientated, bilateral TAP block with 0.25% levobupivacain 17,5ml each side in the triangle of Petit. Postoperative pain treatment followed the same protocole for both groups with 1gram paracetamol intravenously and received patrient-controlled analgesia with intravenous morphine. The time to first request of analgesic, morphine consumption, visual analogue scale (VAS) pain scores and side effects were scored at 2, 4, 6, 8, 12 h postoperatively. Results: The time to first request of analgesic was longer, morphine consumption was lower in TAP group than in the control (p < 0.05). Visual analogue scale (VAS) pain scores at rest and on mouvement were similar in two groups at 2h, but lower in TAP group from 4h (p < 0.05). No severe adverse effects were detected in two groups. Conclusion: TAP block prolonged the time to fisrt request of analgesic and reduced morphine consumption, the VAS pain scores significantly both at rest and on mouvement. Therefore, TAP block is feasible and effective as part of a multimodal analgesia regimen after Caesarean section. Key words: Caesarean section, multimodal pain management, transversus abdominis plane block

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