Warthin’s tumour seems to be the most common benign neoplasm of the parotid gland in Germany

AbstractA rare variant of the cystadenoma of salivary gland origin is presented, which occurred in the parotid of a 36-year-old, otherwise healthy female patient. The tumour showed a dense follicle-containing lymphoid stroma, resembling papillary cystadenoma lymphomatosum (Warthin's tumour). In contrast to that, the epithelial lining gave a more irregular impression and oncocytic metaplasia were completely absent. Light microscopic and immunohistochemical features of the tumour are described and compared with those of classical cystadenoma and papillary cystadenoma lymphomatosum (Warthin's tumour). Other relevant multicystic epithelial parotid lesions, which are commonly associated with a prominent lymphoid component are discussed.

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Necrobiotic xanthogranuloma of the parotid gland

The Journal of Laryngology & Otology ◽

10.1017/s0022215109991563 ◽

2009 ◽

Vol 124 (5) ◽

pp. 569-571 ◽

Cited By ~ 4

Author(s):

A Zainal ◽

M Y Razif ◽

M Makhashen ◽

M Swaminathan ◽

A Mazita

Keyword(s):

Radiation Therapy ◽

Parotid Gland ◽

Rare Condition ◽

Needle Aspiration ◽

Histopathological Diagnosis ◽

Aspiration Cytology ◽

Fine Needle ◽

Clinical Presentations ◽

Warthin’S Tumour ◽

Needle Aspiration Cytology

AbstractObjectives:To highlight the first reported case of necrobiotic xanthogranuloma of the parotid gland. We also review the clinical presentations and treatments for this rare condition.Method:Case report and review of necrobiotic xanthogranuloma.Results:A 48-year-old man presented with a right parotid mass. Fine needle aspiration cytology was suggestive of Warthin's tumour, for which the patient underwent a subtotal parotidectomy. The final histopathological diagnosis was necrobiotic xanthogranuloma.Conclusions:Necrobiotic xanthogranuloma may clinically mimic commoner tumours such as Warthin's tumour. Once diagnosed, the clinician should be wary of extracutaneous manifestations and paraproteinaemias. Because of the variability of presentation, there is no consensus on the best treatment for necrobiotic xanthogranuloma, which may include surgery, chemotherapy, interferon, plasmapheresis and radiation therapy.

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Cyclooxygenase-2 expression in Warthin's tumour

The Journal of Laryngology & Otology ◽

10.1258/0022215054352117 ◽

2005 ◽

Vol 119 (7) ◽

pp. 515-518 ◽

Cited By ~ 2

Author(s):

A H C Loy ◽

T C Putti ◽

L K S Tan

Keyword(s):

Quantitative Analysis ◽

Parotid Gland ◽

Immunohistochemical Staining ◽

Cyclooxygenase 2 ◽

Duct System ◽

Salivary Duct ◽

Epithelial Component ◽

Warthin’S Tumour ◽

Cox 2

Objectives: To determine whether cyclooxygenase-2 (COX-2) is overexpressed in Warthin's tumours, and to characterize its pattern of expression.Methods: Twenty-one paraffin-embedded Warthin's tumour specimens were analysed by immunohistochemical staining for expression of human COX-2. Semi-quantitative analysis of the staining was performed.Results: In all of the specimens, we found that there was overexpression of COX-2 within the epithelial component of the tumours, with no expression in the lymphoid components. There was also overexpression of COX-2 in the salivary duct system of normal parotid tissue.Conclusions: Our results suggest that COX-2 is up-regulated in the epithelial component of Warthin's tumours. Our findings support the hypothesis that Warthin's tumours originate from heterotopic ductal epithelial cells of the parotid gland. The role of COX-2 expression in the pathogenesis of Warthin's tumours remains to be determined.

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Management of Warthin's tumour of the parotid gland

British Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.bjoms.2013.05.071 ◽

2013 ◽

Vol 51 (6) ◽

pp. e101

Author(s):

Haimisha Mistry ◽

Sunil Sah ◽

David Laugharne

Keyword(s):

Parotid Gland ◽

Warthin’S Tumour

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Conservative Surgical Approach to Pleomorphic Adenoma in Parotid Gland: Case Report

Journal of Health Sciences ◽

10.17921/2447-8938.2021v23n2p121-125 ◽

2021 ◽

Vol 23 (2) ◽

pp. 121-125

Author(s):

Davisson Alves Pereira ◽

Eduvaldo Campos Soares Junior ◽

Mariana Da Silva Bonatto ◽

Kallyne Munik Souza Morato ◽

André Luis Fernandes da Silva

Keyword(s):

Parotid Gland ◽

Pleomorphic Adenoma ◽

Clinical Signs ◽

Benign Neoplasm ◽

Surgical Removal ◽

Favorable Prognosis ◽

Benign Nature ◽

Routine Physical Examination ◽

Sixth Decade ◽

Surgical Option

AbstractPleomorphic adenoma is a benign neoplasm of the salivary glands that affects most frequently females in the fourth and sixth decade of life. As it is usually an asymptomatic lesion, it is diagnosed upon routine physical examination. Treatment consists in surgical removal with partial or total involvement of the parotid gland. Conservative enucleation is the least invasive surgical option for this type of lesion. The present work aimed to report a case of pleomorphic adenoma of the parotid gland with eight years of evolution. The tumor was treated conservatively. Patient has been followed for sixth months, and no sensory alterations, fistulae, clinical signs of recurrence, nor any other alteration have been observed so far. Due to the benign nature of the lesion, an evolution with favorable prognosis is expected. Keywords: Adenoma. Benign Neoplasia. Tumor ResumoO Adenoma pleomórfico é uma neoplasia benigna de glândulas salivares, que acomete com maior frequência pessoas do sexo feminino entre a quarta e sexta década de vida. Por se tratar de uma lesão muitas vezes assintomática, geralmente é descoberta através do exame físico de rotina. O seu tratamento consiste em remoção cirúrgica podendo envolver ou não a glândula parótida de maneira parcial ou total. A enucleação conservadora é a modalidade cirúrgica menos invasiva para este tipo de lesão. O presente trabalho tem por objetivo relatar um caso de adenoma pleomórfico em glândula parótida com oito anos de evolução. O tumor foi tratado de maneira conservadora. A paciente está sendo acompanhada há 6 meses e não foram observados até momento alterações sensoriais, fistulas, indícios clínicos de recidiva ou qualquer outra alteração. Devido ao caráter benigno da lesão, espera-se evolução com prognóstico favorável. Palavras-chave: Adenoma. Neoplasia Benigna. Tumor.

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Isoniazid-Resistant Tuberculosis of the Parotid Gland Masquerading as a Benign Neoplasm

Ear Nose & Throat Journal ◽

10.1177/0145561320938159 ◽

2020 ◽

pp. 014556132093815

Author(s):

Subin Lee ◽

Lisa M. Chirch ◽

Lynn Sosa ◽

Qian Wu ◽

Todd E. Falcone

Keyword(s):

Parotid Gland ◽

Benign Neoplasm ◽

Resistant Tuberculosis

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The Role of FNAC in the Diagnosis and Management of Warthin Tumour: Analysis of 74 Cases

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1715148 ◽

2020 ◽

Author(s):

Mohamed Zahran ◽

Sundus Alsedra ◽

Daron Cope ◽

Ahmed Youssef

Keyword(s):

Parotid Gland ◽

False Negative ◽

Benign Neoplasm ◽

Cost Effective ◽

Needle Aspiration ◽

Warthin Tumor ◽

True Negative ◽

Warthin Tumour ◽

Negative Results ◽

Histopathological Correlation

Abstract Introduction After pleomorphic adenoma, Warthin tumor gets its popularity as the second most common benign neoplasm of the parotid gland. Fine-needle aspiration cytology (FNAC) is the most cost-effective and minimally-invasive way to determine the histological character of a parotid gland tumor. Objective To determine the accuracy of FNAC in the diagnosis of Warthin Tumour. Methods A retrospective study conducted between 2014 and 2018. Out of 243 FNACs performed for parotid lesions, a histopathological correlation was established in 74 cases to reveal the accuracy of FNAC in the diagnosis of Warthin tumor. Results A total of 243 FNACs of parotid lesions were performed, and a histopathological correlation was established in 74 (30.4%) cases. Later on, we confirmed that 16 (21.6%) out of these 74 patients had cases of Warthin tumor. In total, 15 (20.3%) out of those 74 cases were confirmed as Warthin tumors on the initial cytology, which revealed a true positive concordance between the cytology and the final histological diagnosis; 55/74 (74%) were true negative results; on the other hand, 1/74 (1.4%) was a false negative, and 3/74 (4.1%) were false positive results. The sensitivity of the FNAC in the diagnosis of Warthin tumor was of 93%, while the specificity was of 94.8%, and the accuracy, of 94.6%. Conclusion In the present study, FNAC had a high diagnostic accuracy, reaching 94%.

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Percutaneous drainage of a parotid gland abscess under contrast-enhanced ultrasound guidance: A case report

Ultrasound ◽

10.1177/1742271x18766705 ◽

2018 ◽

Vol 26 (3) ◽

pp. 182-186

Author(s):

Sean Scattergood ◽

Stephen Moore ◽

Andrew Prior ◽

Gibran T Yusuf ◽

Paul S Sidhu

Keyword(s):

Parotid Gland ◽

Percutaneous Drainage ◽

Ultrasound Guidance ◽

Surgical Intervention ◽

Ultrasound Examination ◽

Contrast Enhanced Ultrasound ◽

Ultrasound Guided ◽

Contrast Enhanced ◽

Co Morbidity ◽

Warthin’S Tumour

A parotid gland abscess is uncommon and if not responding to conservative management, requires surgical intervention. However, surgery is invasive with the risk of complicating facial nerve damage and possible poor cosmetic outcome. We present a case of a parotid gland abscess in association with an underlying Warthin’s tumour requiring percutaneous drainage, as patient co-morbidity precluded a safe surgical approach. Percutaneous drainage was aided by a contrast-enhanced ultrasound examination, which permitted delineation of the fluid aspects of the collection from the underlying tumour and allowed successful percutaneous ultrasound-guided aspiration without complication.

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