Paclitaxel (Taxol®)-induced apoptosis in human epithelioid sarcoma cell lines is enhanced by upregulation of CD95 ligand (FasL/Apo-1L)

2007 ◽  
Vol 134 (6) ◽  
pp. 689-695 ◽  
Author(s):  
Sebastian Heikaus ◽  
Krystian S. Matuszek ◽  
Christoph V. Suschek ◽  
Uwe Ramp ◽  
Petra Reinecke ◽  
...  
Keyword(s):  
Cell Lines ◽  
Epithelioid Sarcoma ◽  
Sarcoma Cell ◽  
Cd95 Ligand ◽  
Induced Apoptosis

The genomic landscape of epithelioid sarcoma cell lines and tumours

2015 ◽  
Vol 238 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Farzad Jamshidi ◽  
Ali Bashashati ◽  
Karey Shumansky ◽  
Brendan Dickson ◽  
Nalan Gokgoz ◽  
...  
Keyword(s):  
Cell Lines ◽  
Epithelioid Sarcoma ◽  
Sarcoma Cell ◽  
Genomic Landscape

Trail induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines

2001 ◽  
Vol 37 ◽  
pp. S111
Author(s):  
Sandra Tomek ◽  
Wolfgang Koestler ◽  
Thomas Brodowicz ◽  
Ingrid Pribill ◽  
Alexandra Budinsky ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Cytotoxic Agents ◽  
Sarcoma Cell ◽  
Induced Apoptosis

Expression of NM23-H1 and NM23-H2 in human epithelioid sarcoma cell lines of different invasive potential in vitro

1995 ◽  
Vol 121 (S1) ◽  
pp. A63-A63
Author(s):  
T. Heymer ◽  
R. Engers ◽  
C. D. Gerharz ◽  
R. Krause-Paulus ◽  
N. El-Badawy ◽  
...  
Keyword(s):  
Cell Lines ◽  
Epithelioid Sarcoma ◽  
Sarcoma Cell ◽  
Invasive Potential

Analysis of growth factor-dependent signalling in human epithelioid sarcoma cell lines

2000 ◽  
Vol 36 (9) ◽  
pp. 1171-1179 ◽  
Author(s):  
C.-D. Gerharz ◽  
U. Ramp ◽  
P. Reinecke ◽  
C. Schardt ◽  
U. Friebe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Lines ◽  
Epithelioid Sarcoma ◽  
Sarcoma Cell

Trail-induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines

2003 ◽  
Vol 39 (9) ◽  
pp. 1318-1329 ◽  
Author(s):  
S Tomek ◽  
W Koestler ◽  
P Horak ◽  
T Grunt ◽  
T Brodowicz ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Cytotoxic Agents ◽  
Sarcoma Cell ◽  
Induced Apoptosis

Absence of temporal ordering of apoptotic features in heat-shock treated leukemia and lymphoma cell lines

1996 ◽  
Vol 54 ◽  
pp. 758-759
Author(s):  
D. W. Fairbain ◽  
M.D. Standing ◽  
K.L. O'Neill
Keyword(s):  
Heat Shock ◽  
Cell Lines ◽  
Chromatin Condensation ◽  
Membrane Integrity ◽  
Resistant Cell ◽  
Membrane Blebbing ◽  
Late Loss ◽  
Induced Apoptosis ◽  
Dying Cells ◽  
In Cells

Apoptosis is a genetically defined response to physiological stimuli that results in cellular suicide. Features common to apoptotic cells include chromatin condensation, oligonucleosomal DNA fragmentation, membrane blebbing, nuclear destruction, and late loss of ability to exclude vital dyes. These characteristics contrast markedly from pathological necrosis, in which membrane integrity loss is demonstrated early, and other features of apoptosis, which allow a non-inflammatory removal of dead and dying cells, are absent. Using heat shock-induced apoptosis as a model for examining stress response in cells, we undertook to categorize a variety of human leukemias and lymphomas with regard to their response to heat shock. We were also interested in determining whether a common temporal order was followed in cells dying by apoptosis. In addition, based on our previous results, we investigated whether increasing heat load resulted in increased apoptosis, with particular interest in relatively resistant cell lines, or whether the mode of death changed from apoptosis to necrosis.

Apoptotic Effects of N-(2-hydroxyphenyl)-2-propylpentanamide on U87-MG and U-2 OS Cells and Antiangiogenic Properties

2020 ◽  
Vol 20 ◽  
Author(s):  
Paola Castillo-Juárez ◽  
Sebastián C. Sanchez ◽  
Alma D. Chávez-Blanco ◽  
Humberto Mendoza-Figueroa ◽  
José Correa-Basurto
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Histone Deacetylases ◽  
Biochemical Mechanism ◽  
Antiproliferative Effects ◽  
Human Osteosarcoma ◽  
Antiproliferative Agent ◽  
Induced Apoptosis ◽  
Apoptotic Effects

Background and Objective: Histone deacetylases (HDACs) are important therapeutic targets for many types of human cancers. A derivative of valproic acid, N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), has antiproliferative properties on some cancer cell lines and inhibits the HDAC1 isoform. Materials and Methods: In this work, HO-AAVPA was tested as an antiproliferative agent in U87-MG (human glioblastoma) and U-2 OS cells (human osteosarcoma), which are types of cancer that are difficult to treat, and its antiangiogenic properties were explored. Results: HO-AAVPA had antiproliferative effects at 48 h with an IC50 = 0.655 mM in U87-MG cells and an IC50 = 0.453 mM in U-2 OS cells. Additionally, in the colony formation assay, HO-AAVPA decreased the number of colonies by approximately 99% in both cell lines and induced apoptosis by 31.3% in the U-2 OS cell line and by 78.2% in the U87-MG cell line. Additionally, HO-AAVPA reduced the number of vessels in chorioallantoid membranes (CAMs) by approximately 67.74% and IL-6 levels in both cell lines suggesting that the biochemical mechanism on cancer cell of HO-AAVPA is different compared to VPA. Conclusion: HO-AAVPA has antiproliferative effects on glioblastoma and osteosarcoma and antiangiogenic properties.

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