scholarly journals Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot study

2009 ◽  
Vol 135 (9) ◽  
pp. 1185-1195 ◽  
Author(s):  
Manuel Valladares-Ayerbes ◽  
Pilar Iglesias-Díaz ◽  
Silvia Díaz-Prado ◽  
Daniel Ayude ◽  
Vanessa Medina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Pilot Study ◽  
Diagnostic Accuracy ◽  
Small Breast ◽  
Bone Marrow Micrometastasis ◽  
Small Breast Epithelial Mucin ◽  
Breast Epithelial

scholarly journals Study on the small breast epithelial mucin tumor tissue expression difference and its relationship with survival in triple-negative breast cancer patients in Han, Miao and Buyi ethnic

2020 ◽  
Author(s):  
Liu Liang ◽  
Ye Weilin ◽  
Liu Hui ◽  
Lu Qili ◽  
Wang Jun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Tissue ◽  
Tissue Expression ◽  
Expression Difference ◽  
Small Breast ◽  
Significant Difference ◽  
Small Breast Epithelial Mucin ◽  
Breast Epithelial ◽  
Tissue Specimens ◽  
Mammary Tissues

Abstract Objective: To investigate Small breast epithelial mucin(SBEM) expression difference in mammary tissues and relationship with survival in thetriple-negative breast cancer(TNBC) patients in Han, Buyi and Miao ethnic.Methods: In our study, SBEM protein expressions were detected by means of immunohistochemistry in 297 patients diagnosed from 2014 to 2015,including 99 normal breast tissue specimens, 99 cases of breast benign tumor tissue specimens and 99 tissues specimens from TNBC patients.Each set of tissue specimens contains 33 samples from Han,Miao and Buyi ethnics, respectively.We analyze the expression of SBEM in different mammary tissues in different ethnics and the association of different SBEM expression levels in tissue of TNBC patients with clinical- pathological features, DFS and OS in Han,Miao and Buyi ethnics,respectively. Results: SBEM expression in breast cancer tumor cells were related to the ki67 in the Han, Miao and Buyi ethnic (P=0.034、0.027、0.047), respectively. There was a marked associations between the SBEM expression level and lymphatic metastasis (P = 0.042、0.039) in the Han and Miao ethnic, while the same results were not found in the Buyi people (P=0.072).There was significant difference in DFS ( P =0.028、0.013)and OS ( P =0.09、0.037) between the high expression group and low expression group in the Han and Miao ethnic.But there was no significant difference in DFS (P = 0.053 ) and OS (P = 0.088 )in the Buyi people.Conclusion: The SBEM positive detection rate was no significant difference in the han, miao and buyi ethnic groups. SBEM was associated with DFS and OS in the Han and Miao ethnic, while no correlation in the Buyi ethnic.

Letter 1: Bone marrow micrometastasis in breast cancer (Br J Surg 2003; 90: 290-301)

2003 ◽  
Vol 90 (6) ◽  
pp. 761-761
Author(s):  
A. Singh ◽  
M. J. Slade ◽  
R. C. Coombes
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Bone Marrow Micrometastasis
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