Oral tongue cancer patients show a better overall survival than base of tongue cancer patients

Although patients with early-stage oral tongue squamous cell carcinoma (OTSCC) show better survival than those with advanced disease, there is still a number of early-stage cases who will suffer from recurrence, cancer-related mortality and worse overall survival. Incorporation of an immune descriptive factor in the staging system can aid in improving risk assessment of early OTSCC. A total of 290 cases of early-stage OTSCC re-classified according to the American Joint Committee on Cancer (AJCC 8) staging were included in this study. Scores of tumor-infiltrating lymphocytes (TILs) were divided as low or high and incorporated in TNM AJCC 8 to form our proposed TNM-Immune system. Using AJCC 8, there were no significant differences in survival between T1 and T2 tumors (p > 0.05). Our proposed TNM-Immune staging system allowed for significant discrimination in risk between tumors of T1N0M0-Immune vs. T2N0M0-Immune. The latter associated with a worse overall survival with hazard ratio (HR) of 2.87 (95% CI 1.92–4.28; p < 0.001); HR of 2.41 (95% CI 1.26–4.60; p = 0.008) for disease-specific survival; and HR of 1.97 (95% CI 1.13–3.43; p = 0.017) for disease-free survival. The TNM-Immune staging system showed a powerful ability to identify cases with worse survival. The immune response is an important player which can be assessed by evaluating TILs, and it can be implemented in the staging criteria of early OTSCC. TNM-Immune staging forms a step towards a more personalized classification of early OTSCC.

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Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy

Radiation Oncology ◽

10.1186/1748-717x-5-43 ◽

2010 ◽

Vol 5 (1) ◽

pp. 43 ◽

Cited By ~ 65

Author(s):

Su Jung Shim ◽

Jihye Cha ◽

Woong Sub Koom ◽

Gwi Eon Kim ◽

Chang Geol Lee ◽

...

Keyword(s):

Cancer Patients ◽

Clinical Outcomes ◽

Tongue Cancer ◽

Postoperative Radiotherapy ◽

Oral Tongue ◽

Oral Tongue Cancer

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The effect of facility volume on treatment guideline compliance and overall survival in oral tongue squamous cell carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.30_suppl.17 ◽

2018 ◽

Vol 36 (30_suppl) ◽

pp. 17-17 ◽

Cited By ~ 1

Author(s):

Samantha Tam ◽

Xianglin L. Du ◽

Carol M. Lewis ◽

Jose-Miguel Yamal ◽

Randal S. Weber

Keyword(s):

Overall Survival ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tongue Cancer ◽

High Volume ◽

Oral Tongue ◽

Case Volume ◽

Guideline Compliance ◽

Oral Tongue Cancer

17 Background: National treatment guidelines guide cancer care using the best available evidence and understanding the drivers of guideline compliance is essential to identifying modifiable factors to improve quality of care. This study aims to explore the impact of facility volume on the rate of guideline compliance in patients with oral tongue cancer and its effect on overall survival. Methods: Using National Cancer Database from 2004 to 2013, this retrospective cohort study investigated patients undergoing curative surgical treatment for oral tongue squamous cell carcinoma. Patients were divided into three tertiles according to mean annual case volume at their treatment facility. Guideline compliance was based on the National Comprehensive Cancer Network oral cavity cancer guidelines. Predictors of guideline compliance and overall survival were determined using multiple logistic regression and Cox Proportional Hazards models. Results: Guideline compliant care was delivered in 54.5% of the 35,810 eligible patients. Those treated at intermediate volume facilities had 1.75 times greater odds of receipt of guideline compliant care (95% CI = 1.57-1.96) and 2.14 times greater in high volume facilities (95% CI = 1.91-2.40) compared to low volume facilities. Guideline compliance (adjusted hazard ratio [HRadj] = 0.78, 95% CI = 0.72-0.84) and treatment at a high volume facility (HRadj= 0.88, 95% CI = 0.80-0.98) were independent predictors of overall survival. Conclusions: Facility volume independently predicted guideline compliance in oral tongue cancer. Guideline compliance and treatment at a high case volume facility were predictors of overall survival. Clinicians should apply guideline compliant care regardless of practice setting and treatment at higher volume centers should be considered.

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B-cell clusters at the invasive margin associate with longer survival in early-stage oral-tongue cancer patients

OncoImmunology ◽

10.1080/2162402x.2021.1882743 ◽

2021 ◽

Vol 10 (1) ◽

pp. 1882743

Author(s):

C. Phanthunane ◽

R. Wijers ◽

M. de Herdt ◽

T.P.M. Langeveld ◽

S. Koljenovic ◽

...

Keyword(s):

B Cell ◽

Cancer Patients ◽

Tongue Cancer ◽

Early Stage ◽

Oral Tongue ◽

Cell Clusters ◽

Invasive Margin ◽

Oral Tongue Cancer

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Clinical outcomes and impact of prognostic factors following adjuvant radiotherapy in oral tongue cancer patients

The Egyptian Journal of Otolaryngology ◽

10.1186/s43163-021-00168-9 ◽

2021 ◽

Vol 37 (1) ◽

Author(s):

Sidharth Pant ◽

Punita Lal ◽

Shagun Misra ◽

Piyush Gupta ◽

K. J. Maria Das ◽

...

Keyword(s):

Prognostic Factors ◽

Cancer Patients ◽

Advanced Disease ◽

Tongue Cancer ◽

Early Stage ◽

Locally Advanced ◽

Oral Tongue ◽

Early Stage Disease ◽

Stage Disease ◽

Oral Tongue Cancer

Abstract Background The purpose of the study was to evaluate survival outcomes in post-operative oral tongue cancer patients undergoing adjuvant radiotherapy (RT) at a tertiary cancer care center and to critically review the impact of various clinical-pathological factors on recurrence and survival. Demographic factors, stage of all the histology proven oral tongue cancer, and treatment details were documented. Overall survival (OS) and recurrence-free survival (RFS) were analyzed along with the potential prognostic factors affecting outcome. Results One hundred forty-four post-operative oral tongue cancer patients referred to our department for adjuvant treatment were evaluated. Median age at presentation was 45 years. Forty-seven patients had pathological early stage disease (stages I and II) and 95 had locally advanced (stages III and IV) disease while post-op details were not present in 2 patients. At a median follow-up of 87 months (60–124) of alive patients, the median RFS for entire cohort was 62 months while median OS was 74 months respectively. Age, perineural invasion (PNI), and grade of the tumor emerged as independent prognostic factors for OS and RFS. Among patients with early stage disease, depth of invasion (DOI), age, and PNI were found as independent prognostic factors for RFS and OS. In locally advanced disease, higher grade, age, and PNI independently impacted the respective survival end points. Conclusions Age (> 45 years), higher grade, and presence of PNI showed inferior survival outcomes across the sub-groups (early versus locally advanced disease). This may warrant adjuvant treatment intensification. DOI > 10 mm was particularly found to worsen survival in early node negative SCC oral tongue patients.

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