Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new findings from an updated meta-analysis

AbstractMechanistic hypotheses suggest that vitamin D and the closely related parathyroid hormone (PTH) may be involved in prostate carcinogenesis. However, epidemiological evidence is lacking for PTH and inconsistent for vitamin D. Our objectives were to prospectively investigate the association between vitamin D status, vitamin D-related gene polymorphisms, PTH and prostate cancer risk. A total of 129 cases diagnosed within the Supplémentation en Vitamines et Minéraux Antioxydants cohort were included in a nested case–control study and matched to 167 controls (13 years of follow-up). 25-Hydroxyvitamin D (25(OH)D) and PTH concentrations were assessed from baseline plasma samples. Conditional logistic regression models were computed. Higher 25(OH)D concentration was associated with decreased risk of prostate cancer (ORQ4 v. Q1 0·30; 95 % CI 0·12, 0·77; Ptrend=0·007). PTH concentration was not associated with prostate cancer risk (Ptrend=0·4) neither did the studied vitamin D-related gene polymorphisms. In this prospective study, prostate cancer risk was inversely associated with 25(OH)D concentration but not with PTH concentration. These results bring a new contribution to the understanding of the relationship between vitamin D and prostate cancer, which deserves further investigation.

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The MTHFR C677T Polymorphism and Prostate Cancer Risk: New Findings from a Meta-analysis of 7306 Cases and 8062 Controls

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2012.13.6.2597 ◽

2012 ◽

Vol 13 (6) ◽

pp. 2597-2604 ◽

Cited By ~ 9

Author(s):

Wei-Bing Zhang ◽

Jun-Hong Zhang ◽

Zheng-Qi Pan ◽

Qi-Sheng Yang ◽

Bo Liu

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Prostate Cancer Risk ◽

Mthfr C677t ◽

C677t Polymorphism ◽

Mthfr C677t Polymorphism ◽

New Findings

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Effect of E-Cadherin (CDH1) -160C/A polymorphism on prostate cancer risk: a meta-analysis

10.1101/015123 ◽

2015 ◽

Author(s):

Bo Yang ◽

Yi He ◽

Xiaofei Wen ◽

Hui Liu ◽

Guoqiang Liao ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Transcriptional Activity ◽

Meta Analysis ◽

Prostate Cancer Risk ◽

Positive Association ◽

Population Based ◽

Cdh1 Gene ◽

Increased Risk ◽

E Cadherin

E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and prostate cancer (PCA)risk remain contradictory, owing to differences in living habits and genetic backgrounds.To derive a more better and comprehensive conclusion, the present meta-analysis was performed.Electronic searches of several databases were conducted for all publications on the association between the CDH1 −160 C/A polymorphism and prostate cancer before Oct 2014. The odds ratio (OR) and its 95% confidence interval (CI) were used for statistical analysis.A total of 7 eligible studies including 1294 cases and 1782 controls were involved in this meta-analysis.Overall, meta-analysis indicated that the -160A allele carriers (AA, CA, AA+CA and A allele) had an increased risk of PCA compared with the homozygotes (CC). In the subgroup analyses by ethnicity, a positive association was found in Asians with A allele, AA, CA, AA+CA genotype and Caucasian descendants with AA genotype, dominant and recessive models. On the contrary, a decreased prostate cancer risk was found in Africans with heterozygous,dominant and allele models.Taken together,this meta-analysis showed that the CDH1 -160A allele might be a risk factor for prostate cancer in Asians and Caucasians. However, this result should be verified by additional population-based studies with large sample sizes.

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