Effects of maternal diabetes on male offspring: high cell proliferation and increased activity of MMP-2 in the ventral prostate

2014 ◽  
Vol 358 (1) ◽  
pp. 257-269 ◽  
Author(s):  
A. A. Damasceno ◽  
C. P. Carvalho ◽  
E. M. B. Santos ◽  
F. V. Botelho ◽  
F. A. Araújo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Maternal Diabetes ◽  
Male Offspring ◽  
Ventral Prostate ◽  
High Cell ◽  
Increased Activity ◽  
High Cell Proliferation

scholarly journals Bioassay-Guided Isolation of Antiproliferative Compounds from Limbarda crithmoides (L.) Dumort

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1893
Author(s):  
Sabrina Adorisio ◽  
Laura Giamperi ◽  
Anahi Elena Ada Bucchini ◽  
Domenico Vittorio Delfino ◽  
Maria Carla Marcotullio
Keyword(s):  
Cell Proliferation ◽  
Nmr Spectroscopy ◽  
Separation Procedure ◽  
High Cell ◽  
Thymol Derivatives ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition ◽  
Dose Dependent ◽  
High Cell Proliferation ◽  
Acute Myeloid

Limbarda crithmoides (L.) Dumort (Asteraceae) n-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (1) and 10-acetoxy-9-chloro-8,9-dehydrothymol (2), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation.

Excessively High Cell Proliferation in Sigmoid Colon After an Oral Purge With Anthraquinone Glycosides

1995 ◽  
Vol 87 (6) ◽  
pp. 452-455 ◽  
Author(s):  
Jan H. Kleibeuker ◽  
Annemieke Cats ◽  
Nynke Zwart ◽  
Nanno H. Mulder ◽  
Machiel J. Hardonk ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Sigmoid Colon ◽  
High Cell ◽  
Anthraquinone Glycosides ◽  
High Cell Proliferation

scholarly journals Depressed type of intramucosal differentiated-type gastric cancer has high cell proliferation and reduced apoptosis compared with the elevated type

2012 ◽  
Vol 16 (1) ◽  
pp. 94-99 ◽  
Author(s):  
Toshihiko Nakamura ◽  
Takashi Yao ◽  
Yoshihiro Kakeji ◽  
Hideaki Anai ◽  
Masaru Morita ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
High Cell ◽  
Depressed Type ◽  
Elevated Type ◽  
High Cell Proliferation

METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS

1972 ◽  
Vol 69 (1) ◽  
pp. 165-173 ◽  
Author(s):  
H. Schmidt ◽  
I. Noack ◽  
K. D. Voigt
Keyword(s):  
Cell Proliferation ◽  
Cell Metabolism ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Nucleic Acid Content ◽  
The Difference ◽  
Independent Effects ◽  
Sites Of Action ◽  
Peripheral Metabolism

ABSTRACT The effect of testosterone and 5α-dihydrotestosterone on protein and nucleic acid content as well as on the activities of some enzymes has been studied in the ventral prostate and the seminal vesicles of immature castrated rats. Both androgens were given intraperitoneally in doses of 1 mg daily for one or three days the rats were sacrificed one day after the last injection. In the prostate it was found that 5α-dihydrotestosterone had a greater effect on DNA increase, i. e. cell proliferation than testosterone, whereas cell metabolism was stimulated by the two androgens to nearly the same extent. In the seminal vesicles a single dose led to the same results as had been obtained in the prostate, i. e. a greater cell proliferative action of 5α-dihydrotestosterone and an equal stimulation of cell metabolism by testosterone and 5α-dihydrotestosterone was also observed. When three doses of the two androgens were given, cell proliferation as well as cell metabolism in the seminal vesicles were significantly more increased after 5α-dihydrotestosterone than after testosterone. The difference of action after systemic administration of the two androgens is explained by their different accumulation and by their different peripheral metabolism in the target tissues. From the partly independent effects of various androgens on cell proliferation and cell metabolism the conclusion may be drawn that there exist at least two intracellular sites of action.

Sign in / Sign up

Export Citation Format

Share Document