scholarly journals The role of neural stem cells in regulating glial scar formation and repair

2021 ◽  
Author(s):  
Alexandra M. Nicaise ◽  
Andrea D’Angelo ◽  
Rosana-Bristena Ionescu ◽  
Grzegorz Krzak ◽  
Cory M. Willis ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Glial Scar ◽  
Model Systems ◽  
The Novel ◽  
The Past ◽  
Regenerative Therapies ◽  
Scar Healing ◽  
Do So

AbstractGlial scars are a common pathological occurrence in a variety of central nervous system (CNS) diseases and injuries. They are caused after severe damage and consist of reactive glia that form a barrier around the damaged tissue that leads to a non-permissive microenvironment which prevents proper endogenous regeneration. While there are a number of therapies that are able to address some components of disease, there are none that provide regenerative properties. Within the past decade, neural stem cells (NSCs) have been heavily studied due to their potent anti-inflammatory and reparative capabilities in disease and injury. Exogenously applied NSCs have been found to aid in glial scar healing by reducing inflammation and providing cell replacement. However, endogenous NSCs have also been found to contribute to the reactive environment by different means. Further understanding how NSCs can be leveraged to aid in the resolution of the glial scar is imperative in the use of these cells as regenerative therapies. To do so, humanised 3D model systems have been developed to study the development and maintenance of the glial scar. Herein, we explore the current work on endogenous and exogenous NSCs in the glial scar as well as the novel 3D stem cell–based technologies being used to model this pathology in a dish.

Remythisierung des Nationalen. Grigol Robakidses Die Hüter des Grals als Gedächtnisroman

2019 ◽  
Vol 54 (1) ◽  
pp. 22-46
Author(s):  
Levan Tsagareli
Keyword(s):  
National Identity ◽  
The Novel ◽  
Cultural Traditions ◽  
The Past ◽  
Self Image ◽  
National Myths ◽  
Do So

Abstract The exile in Germany allowed the Georgian writer Grigol Robakidse to re-work national myths and history more freely. Hence it appears legitimate to read Robakidse’s novel Die Hüter des Grals that was written and published during his exile period as a fiction of memory. The text aims to counteract social oblivion and to prevent the loss of the Georgian identity. Recalling the national past becomes an act of resistance against Soviet rulers and is determined to serve as a weapon against suppression. To do so, the novel allocates the entire storyline to a mythically determined framework that is designed as a fusion of the Georgian and European mythologems, thus demonstrating the proximity of the corresponding cultural traditions. By staging a fight between various interpretations of the past, it not only (re)constructs but also remythologizes the national identity and attaches to it a universal significance. The characters and spaces of the novel are configured in a way that the Georgian (and the congruent Occidental) self-image is represented as sacred, whereas the intracultural (Bolshevist) hetero-image undergoes demonization. According to the conception of the text, a special cultural mission is assigned to Georgia as a country that is able to fulfill the role of a guardian of the Occident’s spirit, its past, and its values.

Tissue regeneration and repair in multiple sclerosis: the role of neural stem cells

2011 ◽  
pp. 60-66
Author(s):  
Stefano Pluchino ◽  
Roberto Furlan ◽  
Luca Muzio ◽  
Gianvito Martino
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Tissue Regeneration

The role of morphine on rat neural stem cells viability, neuro-angiogenesis and neuro-steroidgenesis properties

2017 ◽  
Vol 636 ◽  
pp. 205-212 ◽  
Author(s):  
Nima Abdyazdani ◽  
Alireza Nourazarian ◽  
Hojjatollah Nozad Charoudeh ◽  
Masoumeh Kazemi ◽  
Navid Feizy ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells

P50. Role of glioma produced CM1 in the brain tumor tropism of human neural stem cells

2010 ◽  
Vol 80 ◽  
pp. S33-S34
Author(s):  
J. Jeon ◽  
S. Cho ◽  
K. Cho ◽  
Y. Lee ◽  
M. Lee
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Neural Stem Cells ◽  
Human Neural Stem Cells ◽  
Tumor Tropism ◽  
The Brain

scholarly journals Indestructible Pasts and Paranoid Presents: John Franzen against Active Forgetting in Purity

2019 ◽  
pp. 21-34
Author(s):  
Cristina Garrigós
Keyword(s):  
Traumatic Event ◽  
The Novel ◽  
Contemporary Society ◽  
The Public ◽  
The Past ◽  
Personal Archives ◽  
Conscious Process ◽  
Unconscious Desire ◽  
Selection Of

Forgetting and remembering are as inevitably linked as lifeand death. Sometimes, forgetting is motivated by a biological disorder, brain damage, or it is the product of an unconscious desire derived from a traumatic event (psychological repression). But in some cases, we can motivate forgetting consciously (thought suppression). It is through the conscious repression of memories that we can find self-preservation and move forward, although this means that we create a fable of our lives, as Nietzsche says in his essay “On the Uses and Disadvantages of History for Life” (1997). In Jonathan Franzen’s novel, Purity (2015), forgetting is an active and conscious process by which the characters choose to forget certain episodes of their lives to be able to construct new identities. The erased memories include murder, economical privileges derived from illegal or unethical commercial processes, or dark sexual episodes. The obsession with forgetting the past links the lives of the main characters, and structures the narrative of the novel. The motivated erasure of memories becomes, thus, a way that the characters have to survive and face the present according to a (fake) narrative that they have constructed. But is motivated forgetting possible? Can one completely suppress facts in an active way? This paper analyses the role of forgetting in Franzen’s novel in relation to the need in our contemporary society to deny, hide, or erase uncomfortable data from our historical or personal archives; the need to make disappear stories which we do not want to accept, recognize, and much less make known to the public. This is related to how we manage information in the age of technology, the “selection” of what is to be the official story, and how we rewrite our own history

Lopatina, N. and Fridstein, Y., eds. (2019). ‘Whom thou desertest not, O Genius…’ Goethe in translations by Russian 19th-c. poets. Moscow: Infinitiv: Lingvistika. (In Russ.)

2021 ◽  
pp. 274-279
Author(s):  
G. V. Yakusheva
Keyword(s):  
Cultural Awareness ◽  
Russian Society ◽  
The Novel ◽  
European Literature ◽  
Original Language ◽  
The Past ◽  
Poetic Translation ◽  
Western European

A review of the anthology prepared by N. Lopatina, a renowned Russian bibliographer. The collection includes 187 translations of Goethe’s 78 poems, which are quoted in the original language, and of several poetic fragments from the tragedy Faust, the novel Wilhelm Meister, as well as the cycle West-Eastern Divan, made by 63 Russian 19th-c. poets, representatives of various traditions — from Classicism and Sentimentalism to Symbolism and Acmeism. The collection showcases the high achievements of the country’s school of poetic translation and acute cultural awareness of the Russian society in the 19th c., and focuses on the part of Goethe’s poetic oeuvre that was especially popular with the Russian reader. Another role of the anthology is to bridge a gap in our knowledge and uncover names, often unfairly forgotten, of Russian poets and philologists of the past in their interaction with the Western European literature.

Between the Alternate and the Apocryphal

2019 ◽  
pp. 124-138
Author(s):  
Derek J. Thiess
Keyword(s):  
Literary Representations ◽  
The Novel ◽  
National History ◽  
Alternate History ◽  
The Past ◽  
Material History

This chapter explores connections between two treatments of history in science fictional literature—the apocryphal history and the alternate history—as they deal with material place. Theorists (Jameson, Hughes-Warrington) have explored the role of materialist history in our need to create counterfactuals by examining the cityscapes and structures in literary representations of the past. This essay connects the disparate strands of materialism, place, and religious revisionism via Juan Miguel Aguilera’s La locura de Dios. It reads the novel as both an apocryphal adventure to a “lost world” civilization and an alternate narrative of Spanish national history. La locura comments surprisingly self-consciously on the crystalline fragility of the logic holding material history together, threatened as it is by a revisionist, escapist orthodoxy.

scholarly journals Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase–AIF pathway

2014 ◽  
Vol 1843 (6) ◽  
pp. 1162-1171 ◽  
Author(s):  
Kin Pong U ◽  
Venkataraman Subramanian ◽  
Antony P. Nicholas ◽  
Paul R. Thompson ◽  
Patrizia Ferretti
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Neural Stem Cells ◽  
The Novel ◽  
Peptidylarginine Deiminase ◽  
Human Neural Stem Cells
Sign in / Sign up

Export Citation Format

Share Document