Therapeutic value of laparoscopic adhesiolysis

2001 ◽  
Vol 15 (1) ◽  
pp. 102-102 ◽  
Author(s):  
M. A. Carbajo Caballero ◽  
J. C. Martín del Olmo ◽  
J. I. Blanco ◽  
F. Martín ◽  
M. Toledano ◽  
...  
Keyword(s):  
Laparoscopic Adhesiolysis ◽  
Therapeutic Value

Subjective evaluation of the therapeutic value of laparoscopic adhesiolysis

2000 ◽  
Vol 14 (1) ◽  
pp. 79-81 ◽  
Author(s):  
E. Malik ◽  
C. Berg ◽  
A. Meyhöfer-Malik ◽  
S. Haider ◽  
W. G. Rossmanith
Keyword(s):  
Subjective Evaluation ◽  
Laparoscopic Adhesiolysis ◽  
Therapeutic Value

The Therapeutic Value of Rest

1902 ◽  
Vol 53 (1364supp) ◽  
pp. 21863-21863
Keyword(s):  
Therapeutic Value

POLYPHARMACY IN ELDERLY OUT PATIENTS

2019 ◽  
pp. 16-22
Author(s):  
E.A. Panova ◽  
V.A. Serov ◽  
A.M. Shutov ◽  
N.N. Bakumtseva ◽  
M.Yu. Kuzovenkova
Keyword(s):  
Drug Therapy ◽  
Elderly Patients ◽  
Drug Prescription ◽  
Daily Practice ◽  
Drug Prescriptions ◽  
Ulcer Disease ◽  
Start Criteria ◽  
Therapeutic Value ◽  
Elderly Outpatients ◽  
Oncological Diseases

The aim of the work is to study the daily practice of prescribing drugs at the outpatient stage of medical care and to analyze the data obtained based Beers 2012 criteria and STOPP / START version 1. Materials and Methods. The authors analyzed drug prescriptions for 150 outpatients, who were over 65 years old. Results. Cardiovascular diseases, diseases of the osteo-articular system and type 2 diabetes mellitus prevailed in the morbidity structure of patients. Oncological diseases, thyroid diseases, bronchial asthma, cataracts, pancreatitis, anemia, peptic ulcer disease were diagnosed in some patients. All drug prescriptions during the year were taken into account. Simultaneous prescription of more than 4 drugs was considered polypharmacy. All the patients were monitored for a year since drug prescriptions had been made. Death was taken as the end point. The authors considered drug therapy to be irrational according to Beers and STOPP / START criteria. The therapeutic value of drug prescription audit based on restrictive lists was evaluated. Conclusions. Polypharmacy is observed in more than half of elderly outpatients. According to Beers 2012 criteria, irrational drug therapy was detected in 20 % of elderly patients, according to STOPP and START lists – in 43.3 % and 66.6 %, respectively. The lack of drug prescriptions in accordance with START criteria is associated with increased mortality of elderly patients. Keywords: polypharmacy, pharmacotherapy, drug therapy, geriatrics, restrictive lists, Beers criteria, STOPP / START criteria. Цель работы – изучение ежедневной практики назначения лекарственных препаратов на амбулаторном этапе медицинской помощи и анализ полученных данных на основе критериев ограничительных перечней Бирса 2012 г. и STOPP/START версии 1. Материалы и методы. Проанализированы лекарственные назначения 150 пациентам старше 65 лет, находившимся на амбулаторном лечении. Результаты. В структуре заболеваемости пациентов преобладали сердечно-сосудистые заболевания, а также болезни костно-суставной системы и сахарный диабет 2-го типа. Онкологические заболевания, заболевания щитовидной железы, бронхиальная астма, катаракта, панкреатит, анемия, язвенная болезнь диагностированы у единичных больных. Учитывались все лекарственные назначения в течение года. За полипрагмазию принималось одновременное назначение более 4 препаратов. В течение последующего года отслеживалось состояние пациентов, за конечную точку принята смерть. Выявлена нерациональная лекарственная терапия на основе критериев Бирса и STOPP/START. Оценена терапевтическая значимость аудита лекарственных назначений по ограничительным перечням. Выводы. Полипрагмазия наблюдается более чем у половины амбулаторных пациентов пожилого возраста. На основе критериев ограничительных перечней Бирса 2012 г. нерациональная лекарственная терапия выявлена у 20 % пациентов пожилого возраста, на основе критериев STOPP и START – у 43,3 и 66,6 % соответственно. Отсутствие назначений лекарств в соответствии с критериями START ассоциировано с увеличением смертности пациентов пожилого возраста. Ключевые слова: полипрагмазия, фармакотерапия, лекарственная терапия, гериатрия, ограничительные перечни, критерии Бирса, критерии STOPP/START.

Role of Laparoscopic Adhesiolysis in Adhesive Intestinal Obstruction

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ahmed Lotfy Ali Amer ◽  
Osama Eltih ◽  
waleed Abd-Elhady
Keyword(s):  
Intestinal Obstruction ◽  
Laparoscopic Adhesiolysis ◽  
Adhesive Intestinal Obstruction

Cancer Stem Cell Niche in Colorectal Cancer and Targeted Therapies

2020 ◽  
Vol 26 (17) ◽  
pp. 1979-1993 ◽  
Author(s):  
Hao Wang ◽  
Guihua Cui ◽  
Bo Yu ◽  
Meiyan Sun ◽  
Hong Yang
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell Niche ◽  
Tumor Initiating Cells ◽  
Ideal Model ◽  
Cytotoxic Effects ◽  
Therapeutic Value ◽  
Cancer Initiation ◽  
Cell Niche ◽  
New Strategies ◽  
Common Malignancy

Cancer stem cells (CSCs), also known as tumor-initiating cells, are a sub-population of tumor cells found in many human cancers that are endowed with self-renewal and pluripotency. CSCs may be more resistant to conventional anticancer therapies than average cancer cells, as they can easily escape the cytotoxic effects of standard chemotherapy, thereby resulting in tumor relapse. Despite significant progress in related research, effective elimination of CSCs remains an unmet clinical need. CSCs are localized in a specialized microenvironment termed the niche, which plays a pivotal role in cancer multidrug resistance. The niche components of CSCs, such as the extracellular matrix, also physically shelter CSCs from therapeutic agents. Colorectal cancer is the most common malignancy worldwide and presents a relatively transparent process of cancer initiation and development, making it an ideal model for CSC niche research. Here, we review recent advances in the field of CSCs using colorectal cancer as an example to illustrate the potential therapeutic value of targeting the CSC niche. These findings not only provide a novel theoretical basis for in-depth discussions on tumor occurrence, development, and prognosis evaluation, but also offer new strategies for the targeted treatment of cancer.

Sign in / Sign up

Export Citation Format

Share Document