The role of urinary NGAL and serum cystatin C in assessing the severity of ureteropelvic junction obstruction in infants

2019 ◽  
Vol 35 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Antigoni Pavlaki ◽  
Nikoleta Printza ◽  
Evangelia Farmaki ◽  
Stella Stabouli ◽  
Anna Taparkou ◽  
...  
Keyword(s):  
Cystatin C ◽  
Ureteropelvic Junction Obstruction ◽  
Ureteropelvic Junction ◽  
Urinary Ngal ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Anna Cyganek ◽  
Aleksandra Wyczalkowska-Tomasik ◽  
Patrycja Jarmuzek ◽  
Barbara Grzechocinska ◽  
Zoulikha Jabiry-Zieniewicz ◽  
...  
Keyword(s):  
Cystatin C ◽  
Cathepsin B ◽  
Proteolytic Enzymes ◽  
Late Pregnancy ◽  
Control Group ◽  
Study Group ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Peripartum Period

Objectives. The aim of the study was to evaluate the activity of cathepsin B, collagenases, trypsin, and plasmin and concentration of cystatin C in serum of healthy pregnant women in peripartum period.Study Design. The study group included 45 women in uncomplicated pregnancies. Blood samples were collected in four time points. Enzyme activity was measured by spectrofluorometric method. The level of cystatin C was measured using immunonephelometric method.Results. Mean activity of cathepsin B and the level of serum cystatin C were significantly higher in the study group. Collagenase activity was significantly lower in the study group than the control group. No differences in collagenase, plasmin, and trypsin activity on each day of the peripartum period were found.Conclusion. High activity of cathepsin B and increased level of cystatin C are typical for women in late pregnancy. Those levels significantly decrease after delivery which can be associated with potential role of those markers in placental separation. The insignificant changes of cystatin C level in the peripartum period seem to exclude the possibility of using cystatin C as a marker for renal insufficiency in the peripartum period but additional research is necessary to investigate the matter further.

The role of serum cystatin C in estimation of renal function in survivors of critical illness

2020 ◽  
Vol 59 ◽  
pp. 201-206
Author(s):  
Jirarat Eiamcharoenying ◽  
Win Kulvichit ◽  
Nuttha Lumlertgul ◽  
Tawatchai Chaiwatanarat ◽  
Sadudee Peerapornratana ◽  
...  
Keyword(s):  
Renal Function ◽  
Critical Illness ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Role of serum cystatin-C and beta-2 microglobulin as early markers of renal dysfunction in children with beta thalassemia major

2017 ◽  
Vol Volume 10 ◽  
pp. 261-268 ◽  
Author(s):  
Ola Galal Behairy ◽  
Eman Abd Almonaem ◽  
Neveen Abed ◽  
Omima Abdel Haiea ◽  
Rasha Zakaria ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Cystatin C ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Early Markers ◽  
Beta 2 ◽  
Beta 2 Microglobulin

The Predictive Role of Serum Cystatin C Levels in Polycystic Ovary Syndrome in Adolescents

2016 ◽  
Vol 29 (4) ◽  
pp. 353-356 ◽  
Author(s):  
Mehmet Çınar ◽  
Rıfat Taner Aksoy ◽  
Ali İrfan Güzel ◽  
Aytekin Tokmak ◽  
Tuğba Çandar ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cystatin C ◽  
Polycystic Ovary ◽  
Serum Cystatin C ◽  
Ovary Syndrome ◽  
Serum Cystatin ◽  
Predictive Role

scholarly journals Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka

2021 ◽  
Vol 18 (6) ◽  
pp. 3278
Author(s):  
K.S.M. Abdul ◽  
P. Mangala C.S. De Silva ◽  
E.M.D.V. Ekanayake ◽  
W.A.K.G. Thakshila ◽  
S.D. Gunarathna ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Kidney Function ◽  
Cystatin C ◽  
Kidney Injury ◽  
Unknown Etiology ◽  
Urinary Ngal ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Kidney Injury Molecule 1

Extensive use of herbicides is common among rural agricultural workers in Sri Lanka. Recent studies have postulated their role in the development of chronic kidney disease of unknown etiology (CKDu). Paraquat and glyphosate are leading herbicides used by sugarcane farmers (SF), hence occupational exposure is inevitable. This study examined the expression of urinary paraquat, glyphosate and biomarkers among residential SF in CKDu emerging regions, Warunagama (WA) and Rahathangama (RH), in the Uva Province with non-endemic Matara (MA) in the Southern Province of Sri Lanka. Urinary glyphosate, Paraquat, Kidney injury molecule -1 (KIM-I), Neutrophil gelatinase-associated lipocalin (NGAL) andβ2-microglobulin (B2M) were determined using enzyme-linked immunosorbent assays (ELISA). Urinary creatinine, microalbumin, serum creatinine (SCr), serum cystatin C, estimated glomerular filtration rate (eGFR), and albumin creatinine ratio (ACR) were also assessed. Generally, herbicide residues and kidney injury biomarkers were higher in SF compared to the non-endemic MA. Creatinine-adjusted urinary glyphosate and paraquat levels were significantly higher in WA compared to MA. ACR in RH (median 14.9; IQR 5.4–393.1 mg/g) and WA (23.7; 11.5–64.6) was significantly higher than MA (4.3; 2.2–6.7). This study reports 39 individuals with impaired kidney function among SF in Sri Lanka for the first time. Urinary NGAL levels were significantly higher in both WA (median 2.14; IQR 1.28–6.15 ng/mg Cr) and RH (3.09; 1.15–9.09) compared to MA (1.28; 0.56–2.81). However, urinary KIM-I levels in RH (3.2; 1.29–106.1 ng/g Cr) and WA (3.6; 1.94–115.1) were not significantly higher in MA (1.74; 0.76–116.9). Urinary NGAL (r = 0.493), eGFR (r = −0.147) and ACR (r = 0.171) significantly correlated with urinary glyphosate, but not with urinary paraquat levels. Urinary KIM-1 levels did not correlate with either urinary glyphosate or paraquat, while urinary B2M and serum cystatin C levels showed significant correlation with urinary glyphosate levels. The current study reports higher urinary herbicide levels among sugarcane farmers in WA and RH, and that is potentially linked to the subsequent decline in kidney function, as indicated by ACR, eGFR, and NGAL. We posit that these indicators may serve as markers to detect renal injury among herbicide-exposed SF in Rural Sri Lanka.

scholarly journals Early Identification of Acute Kidney Injury after Bariatric Surgery: Role of NGAL and Cystatin C

2014 ◽  
Vol 6 (1) ◽  
pp. 50-59
Author(s):  
Sidoti Anna ◽  
Giacalone Marilu ◽  
Abramo Antonio ◽  
Anselmino Marco ◽  
Carlo Donadio ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Acute Kidney Injury ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Kidney Injury ◽  
Urinary Ngal ◽  
Paired Data ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Significant Difference

Background: The aim of our study was to evaluate plasmatic and urinary NGAL and serum cystatin C as early diagnostic markers of acute kidney injury in obese patients undergoing bariatric surgery. Methods: For this this prospective observational study, we recruited 23 patients undergoing gastric by-pass or sleeve gastrectomy, and admitted to the Low Dependence Unit after the surgery. Plasma NGAL (pNGAL), urinary NGAL (uNGAL), serum cystatin C, serum creatinine, and serum urea were measured before surgery as well as 10 h and 24 h after surgery. Mean values of pNGAL, uNGAL, cystatin C, creatinine, and urea concentrations of pre- and post-surgery periods were compared using Student’s t test for paired data. We also evaluated the presence of correlation between modifications of NGAL and cystatin C after surgery and fluid balance, hydration (ml/kg) and diuresis using Pearson’s coefficient of correlation. Results: No patient developed AKI according to the AKIN criteria. pNGAL was significantly higher at T10h than T0 (p=0.004). There was no significant difference between uNGAL at T0 and T10h (p=0.53) and between uNGAL at T0 and T24h (p=0.31). uNGAL at T was significantly higher in comparison to T10h (p=0.024). uNGAL concentrations were normal in all patients at every time step. Cystatin C concentration did not increase after surgery. Serum creatinine level was significantly higher at T48h, despite being still within the normal range, when compared to T0 (p=0.038). Conclusion: Our study shows that pNGAL can reflect mild tubular damage as its levels increase within a few hours from surgery and return to normal limits afterwards. Concerning uNGAL, there is a minimal increase at T24h, when NGAL concentration in plasma has already decreased. Serum cystatin C does not show any relevant kidney changes, or at least, no more than those ones shown by pNGAL.

scholarly journals Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Hui Wang ◽  
Lijian Gao ◽  
Cuiyu Meng ◽  
Nengwang Yu ◽  
Feilong Yang ◽  
...  
Keyword(s):  
Cystatin C ◽  
Clinical Information ◽  
Clinicopathological Characteristics ◽  
Tumor Characteristics ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Tumorigenesis And Progression ◽  
Urothelial Tumors ◽  
Pretreatment Serum

The role of cystatin C (Cys-C) in tumorigenesis and progression of bladder urothelial tumors (BUT) is still indefinite. We retrospectively collected the clinical information from the records of 425 BUT patients. Pretreatment serum Cys-C levels were compared across the various groups. Then we subgroup the patients with GFR ≥ 90 mg/min/1.73 m2, to exclude the effects of lower renal function on cystatin C. No statistically significant differences in the levels of serum Cys-C were found among the tumor characteristics (allP>0.05). In conclusion, circulating Cys-C was not a reliable predictor for clinicopathological characteristics of BUT patients.

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