Assessing serum albumin concentration, lymphocyte count and prognostic nutritional index might improve prognostication in patients with myelofibrosis

Abstract Background The prognostic nutritional index (PNI) reflects immunonutritional status. We evaluated the effects of postoperative PNI and perioperative changes in the PNI on overall survival (OS) in glioblastoma (GBM) patients. Methods Demographic, laboratory, and clinical data were retrospectively collected from 335 GBM patients. Preoperative and postoperative PNIs were calculated from serum albumin concentration and lymphocyte count, which were measured within 3 weeks before surgery and 1 month after surgery. Patients were classified into high (n = 206) or low (n = 129) postoperative PNI groups according to the postoperative PNI cutoff value and further classified into four groups according to the cutoff values of the preoperative and postoperative PNIs, as follows: Group HH (both high PNIs, n = 92), Group HL (high preoperative and low postoperative PNI, n = 70), Group LH (low preoperative and high postoperative PNI, n = 37), and Group LL (both low PNIs, n = 136). Results The median OS was significantly longer in the high postoperative PNI (PNI ≥ 50.2) group than the low postoperative PNI (PNI < 50.2) group (24.0 vs. 15.0 months, p < 0.001). In multivariate analysis, high postoperative PNI was a significant predictor of OS. OS was significantly longer in Group HH than in Group LL and seemed longer in Group HH than in Group HL and in Group LH than in Group LL. OS was not different between Groups HH and LH or between Groups HL and LL. Conclusions High postoperative PNI was associated with improved OS and perioperative changes in PNI may provide additional important information for prognostic prediction in GBM patients.

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Nutritional Results of Roux-en-Y Pouch Reconstruction After Total Gastrectomy for Gastric Cancer

International Surgery ◽

10.9738/intsurg-d-17-00042.1 ◽

2018 ◽

Vol 103 (7-8) ◽

pp. 409-414

Author(s):

Chikashi Shibata ◽

Ryuji Nakamura ◽

Hitoshi Ogawa ◽

Kaori Koyama ◽

Kazuaki Mukouda ◽

...

Keyword(s):

Gastric Cancer ◽

Serum Albumin ◽

Total Gastrectomy ◽

Lymphocyte Count ◽

Prognostic Nutritional Index ◽

Total Lymphocyte Count ◽

Stage I ◽

Nutritional Index ◽

Pouch Reconstruction ◽

Nutritional Advantage

Objective: The aim of the present study was to describe the nutritional advantage of pouch reconstruction. Summary of background data: Roux-en-Y (RY) pouch reconstruction might improve patients' quality of life compared with RY reconstruction without a pouch after total gastrectomy for gastric cancer. Methods: Clinical records were retrospectively reviewed in 9 and 30 patients with gastric cancer for stages I to III diseases in the pouch and RY groups, respectively, and perioperative and nutritional results were studied. Nutritional results were studied for hemoglobin, serum albumin, total lymphocyte count, and prognostic nutritional index for 5 years postoperatively. Results: Intraoperative blood loss did not differ between 2 groups, and operative time in the pouch group was prolonged compared with the RY group. All parameters we studied for nutritional results did not differ between the pouch and RY groups in patients with stages I to III diseases. When nutritional results were investigated in patients with stage I diseases, the total lymphocyte count at 2 years and prognostic nutritional index at 2 and 3 years postoperatively were greater in the pouch group than RY group, but the increase was not obvious at 4 to 5 years after the operation, and serum albumin and hemoglobin did not differ between 2 groups. Conclusions: These results indicate that the nutritional advantage of pouch reconstruction is very limited after total gastrectomy because the nutritional benefits of pouch reconstruction were observed in 2 of 4 parameters in patients with stage I at 2 and 3 years postoperatively.

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Serum Albumin Concentration and Cognitive Impairment

Current Alzheimer Research ◽

10.2174/1872209197471563128 ◽

2009 ◽

Vol 999 (999) ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

David J. Llewellyn

Keyword(s):

Cognitive Impairment ◽

Serum Albumin ◽

Albumin Concentration ◽

Serum Albumin Concentration

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Low serum albumin concentration is associated with increased risk of osteoporosis in postmenopausal patients with rheumatoid arthritis

Journal of Orthopaedic Science ◽

10.1016/j.jos.2021.08.018 ◽

2021 ◽

Author(s):

Yoshio Nagayama ◽

Kosuke Ebina ◽

Hideki Tsuboi ◽

Makoto Hirao ◽

Jun Hashimoto ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Serum Albumin ◽

Albumin Concentration ◽

Serum Albumin Concentration ◽

Increased Risk ◽

Low Serum

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Prognostic nutritional index is correlated with disease activity in patients with systemic lupus erythematosus

Lupus ◽

10.1177/0961203318787058 ◽

2018 ◽

Vol 27 (10) ◽

pp. 1697-1705 ◽

Cited By ~ 5

Author(s):

S S Ahn ◽

S M Jung ◽

J J Song ◽

Y-B Park ◽

S-W Lee

Keyword(s):

Systemic Lupus Erythematosus ◽

Logistic Regression ◽

Regression Analysis ◽

Disease Activity ◽

Lupus Erythematosus ◽

Lymphocyte Count ◽

Prognostic Nutritional Index ◽

Systemic Lupus ◽

Nutritional Index ◽

Laboratory Variables

The prognostic nutritional index (PNI), which is calculated using serum albumin level and total lymphocyte count in the peripheral blood, is regarded as an index that reflects the immunonutritional status of patients. PNI was calculated in 217 systemic lupus erythematosus (SLE) patients according to the following formula: 10 × serum albumin value (g/dL) + 0.005 × peripheral lymphocyte count (/mm3). Pearson’s correlation analysis was used to elucidate the correlation between continuous variables. Linear and logistic regression analyses were performed to assess the correlation between laboratory variables and SLE Disease Activity Index-2000 (SLEDAI-2 K) and to differentiate between active and inactive SLE. Ninety-three patients were classified as active SLE (SLEDAI-2 K ≥ 5) and 124 as inactive SLE. Patients with active SLE exhibited lower median PNI than those with inactive SLE (39.0 vs. 49.1, p < 0.001). Multivariable logistic regression analysis revealed PNI as an independent predictor of active SLE. Multivariable linear regression analysis revealed that PNI was significantly correlated with laboratory variables of SLEDAI-2 K, erythrocyte sedimentation rate, C-reactive protein and SLEDAI-2 K. Furthermore, in patients who switched from active to inactive SLE after treatment ( n = 55), PNI increased as disease activity improved ( p < 0.001), which suggests that PNI may be useful for estimating SLE activity.

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Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study

Medical Principles and Practice ◽

10.1159/000499738 ◽

2019 ◽

Vol 28 (5) ◽

pp. 401-409 ◽

Cited By ~ 2

Author(s):

Setor K. Kunutsor ◽

Ari Voutilainen ◽

Michael R. Whitehouse ◽

Samuel Seidu ◽

Jussi Kauhanen ◽

...

Keyword(s):

Serum Albumin ◽

Area Under The Curve ◽

Fracture Prevention ◽

Albumin Concentration ◽

Serum Albumin Concentration ◽

Baseline Serum ◽

Increased Risk ◽

New Findings ◽

Caucasian Men ◽

Low Serum

Objective: Low serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. Subjects and Methods: Baseline serum albumin concentrations were measured in 2,245 men aged 42–61 years in the Kuopio Ischemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures. Results: A total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05–1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01–1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37–4.48) and 2.26 (1.23–4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850. Conclusion: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.

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