scholarly journals Feasibility and suitability of a graded exercise test in patients with aggressive hemato-oncological disease

Author(s):  
Anja Großek ◽  
Thomas Elter ◽  
Max Oberste ◽  
Florian Wolf ◽  
Niklas Joisten ◽  
...  

Abstract Purpose Physical activity promises to reduce disease-related symptoms and therapy-related side effects in patients suffering from aggressive lymphoma (L) or acute leukemia (AL). For an efficient training program, determination of patients’ physical capacity with a purposive exercise test is crucial. Here, we evaluated the feasibility and suitability of a graded exercise test (GXT) frequently applied in patients suffering from solid tumors by assessing whether patients achieved criteria for maximal exercise testing according to the American College of Sports Medicine (ACSM). Methods The GXT was performed by 51 patients with an aggressive L or AL prior to the start or in the earliest possible phase of high-dose chemotherapy, following a recommended protocol for cancer patients, starting at 20 Watts (W), with an increase of 10 W/min until volitional exhaustion. Subsequently, we investigated whether the following ACSM criteria were fulfilled: (1) failure of heart rate to increase despite increasing workload, (2) post-exercise capillary lactate concentration ≥ 8.0 mmol L−1, (3) rating of perceived exertion at exercise cessation > 17 on the 6–20 Borg Scale. Results Out of 51 patients, two, six, and 35 participants met the first, second, and third criterion, respectively. No relevant relationships between the completion of the criteria and patients’ characteristics (e.g., gender, age) were found. Conclusion Although results of this study suggest a general feasibility of the applied GXT, the ACSM criteria were not met by the majority of the participants. Therefore, this study raises doubts about the suitability of the GXT protocol and the ACSM criteria for this group of patients.

2019 ◽  
Vol 14 (9) ◽  
pp. 1244-1249 ◽  
Author(s):  
Chelsie E. Winchcombe ◽  
Martyn J. Binnie ◽  
Matthew M. Doyle ◽  
Cruz Hogan ◽  
Peter Peeling

Purpose: To determine the reliability and validity of a power-prescribed on-water (OW) graded exercise test (GXT) for flat-water sprint kayak athletes. Methods: Nine well-trained sprint kayak athletes performed 3 GXTs in a repeated-measures design. The initial GXT was performed on a stationary kayak ergometer in the laboratory (LAB). The subsequent 2 GXTs were performed OW (OW1 and OW2) in an individual kayak. Power output (PWR), stroke rate, blood lactate, heart rate, oxygen consumption, and rating of perceived exertion were measured throughout each test. Results: Both PWR and oxygen consumption showed excellent test–retest reliability between OW1 and OW2 for all 7 stages (intraclass correlation coefficient > .90). The mean results from the 2 OW GXTs (OWAVE) were then compared with LAB, and no differences in oxygen consumption across stages were evident (P ≥ .159). PWR was higher for OWAVE than for LAB in all stages (P ≤ .021) except stage 7 (P = .070). Conversely, stroke rate was lower for OWAVE than for LAB in all stages (P < .010) except stage 2 (P = .120). Conclusions: The OW GXT appears to be a reliable test in well-trained sprint kayak athletes. Given the differences in PWR and stroke rate between the LAB and OW tests, an OW GXT may provide more specific outcomes for OW training.


Author(s):  
Hannah F. Sangan ◽  
James G. Hopker ◽  
Glen Davison ◽  
Shaun J. McLaren

Purpose: To assess the reliability and construct validity of a self-paced, submaximal run test (SRTRPE) for monitoring aerobic fitness. The SRTRPE monitors running velocity (v), heart rate (HRex), and blood lactate concentration (B[La]), during three 3-minute stages prescribed by ratings of perceived exertion (RPEs) of 10, 13, and 17. Methods: Forty (14 female) trained endurance runners completed a treadmill graded exercise test for the determination of maximal oxygen consumption (VO2max), v at VO2max (vVO2max), and v at 2 mmol·L−1 (vLT1) and 4 mmol·L−1 (vLT2) B[La]. Within 7 days, participants completed the SRTRPE. Convergent validity between the SRTRPE and graded exercise test parameters was assessed through linear regression. Eleven participants completed a further 2 trials of the SRTRPE within a 72-hour period to quantify test–retest reliability. Results: There were large correlations between v at all stages of the SRTRPE and VO2max (r range = .57–.63), vVO2max (.50–.66), and vLT2 (.51–.62), with vRPE 17 displaying the strongest associations (r > .60). Intraclass correlation coefficients (ICC3,1) were moderate to high for parameters v (range = .76–.84), HRex (.72–.92), and %HRmax (.64–.89) at all stages of the SRTRPE. The corresponding coefficients of variation were 2.5% to 5.6%. All parameters monitored at intensity RPE 17 displayed the greatest reliability. Conclusions: The SRTRPE was shown to be a valid and reliable test for monitoring parameters associated with aerobic fitness, displaying the potential of this submaximal, time-efficient test to monitor responses to endurance training.


2009 ◽  
Vol 46 (6) ◽  
pp. 1150-1153 ◽  
Author(s):  
Jeremy B. J. Coquart ◽  
Christine Lemaire ◽  
Alain-Eric Dubart ◽  
Claire Douillard ◽  
David-Pol Luttenbacher ◽  
...  

2013 ◽  
Vol 38 (12) ◽  
pp. 1211-1216 ◽  
Author(s):  
Alexis R. Mauger ◽  
Alan J. Metcalfe ◽  
Lee Taylor ◽  
Paul C. Castle

The novel self-paced, cycle-based maximal oxygen uptake (V̇O2max) test (SPV) has been shown to produce higher V̇O2max values than standard graded exercise test (GXT) protocols. This study sought to ascertain whether these observations would also be apparent in a self-paced, treadmill-based test design. Fourteen trained male runners performed a standard GXT on a motorised treadmill and a self-paced V̇O2max test on a nonmotorised treadmill in a counter-balanced design. The GXT included a plateau verification and was designed to last between 8 and 12 min. The self-paced test included 5 × 2 min stages and allowed participants to set their own running speed based on fixed increments in rating of perceived exertion. Significantly higher V̇O2max values (t[13] = 3.71, p = 0.003) were achieved in the self-paced test (64.4 ± 7.3 mL·kg−1·min−1) compared with the GXT (61.3 ± 7.3 mL·kg−1·min−1), and 13 of the 14 participants achieved the same or higher V̇O2max values in the self-paced test. Higher (p = 0.01) maximum heart rates were observed in the GXT (191 ± 10 beats·min−1 vs. 187 ± 7 beats·min−1), but no differences were observed in any other recorded variables. The self-paced V̇O2max test may provide a more valid means of measuring V̇O2max than the GXT and suggests that a V̇O2 plateau during a GXT does not always signify achievement of a definitive V̇O2max. These results provide further support that self-paced V̇O2max testing produces higher values for maximal oxygen uptake.


2000 ◽  
Vol 6 (3) ◽  
pp. 176-180 ◽  
Author(s):  
A T White ◽  
T E Wilson ◽  
S L Davis ◽  
J H Petajan

Many individuals with MS experience heat sensitivity that may be associated with transient increases in the frequency of clinical signs and symptoms. Although physical activity may be beneficial for those with MS, induced thermal loads may preclude participation in exercise and other daily activities. This project was designed to evaluate the effects of precooling on physical function. Six thermosensitive MS patients were studied. Participants performed a graded exercise test to determine maximal oxygen uptake (VO2max) on a combined arm-leg ergometer. Thermal load was induced by 30 min of exercise under noncooled and precooled conditions at a workrate corresponding to 60% VO2max. Precooling consisted of 30 min lower body immersion in 16-178C water. Fatigue and 25-ft walk performance were assessed before, immediately after, and 30 min following exercise. No treatment differences in VO2 were observed. Rectal temperature, heart rate, and rating of perceived exertion (RPE) were significantly lower during the precooled exercise trial compared to the noncooled trial. Immediately following exercise, 25-ft walk performance and fatigue scores showed significantly greater deterioration in the noncooled condition. Precooling was effective in preventing gains in core temperature with physical work and may allow heat-sensitive individuals with MS to exercise with greater physical comfort.


Author(s):  
J Clark

Objective. Despite their widespread use in exercise testing, few data are available on the effect of wearing respiratory gas collection (RGC) systems on exercise test performance. Industrial-type mask wear is thought to impair exercise performance through increased respiratory dead space, flow resistance and/or discomfort when compared with RGC facemasks, but whether performance decrements exist for RGC facemask wear versus non-wear is unclear. The objective of this study was to evaluate the difference in incremental exercise test performance with and without a RGC system. Incremental exercise test performance with and without a respiratory gas collection system  Design. Twenty moderately active males (age 21.0 ± 1.9 years; VO2peak 55.9 ± 3.0 ml∙kg-1∙min-1) performed two progressive treadmill tests to volitional exhaustion. In random order subjects ran with (MASK) or without (NO-MASK) a RGC facemask and flow sensor connected to a gas analyzer. Descriptive data (mean ± SD) were determined for all parameters. The Wilcoxon signed rank test for paired differences was used to assess mean differences between MASK and NO-MASK conditions. Results. Exercise time to exhaustion, peak treadmill speed, peak blood lactate concentration, peak heart rate and rating of perceived exertion (RPE) were not different (p>0.05) between MASK and NO-MASK conditions. Conclusions. Incremental exercise test performance is not adversely affected by RGC and analysis equipment, at least in short duration progressive treadmill exercise. Respiratory gas analysis during exercise testing for diagnostic, performance assessment or training prescription purposes would appear to be unaffected by RGC systems.


Author(s):  
J Clark

Objective. Despite their widespread use in exercise testing, few data are available on the effect of wearing respiratory gas collection (RGC) systems on exercise test performance. Industrial-type mask wear is thought to impair exercise performance through increased respiratory dead space, flow resistance and/or discomfort when compared with RGC facemasks, but whether performance decrements exist for RGC facemask wear versus non-wear is unclear. The objective of this study was to evaluate the difference in incremental exercise test performance with and without a RGC system. Incremental exercise test performance with and without a respiratory gas collection system  Design. Twenty moderately active males (age 21.0 ± 1.9 years; VO2peak 55.9 ± 3.0 ml∙kg-1∙min-1) performed two progressive treadmill tests to volitional exhaustion. In random order subjects ran with (MASK) or without (NO-MASK) a RGC facemask and flow sensor connected to a gas analyzer. Descriptive data (mean ± SD) were determined for all parameters. The Wilcoxon signed rank test for paired differences was used to assess mean differences between MASK and NO-MASK conditions. Results. Exercise time to exhaustion, peak treadmill speed, peak blood lactate concentration, peak heart rate and rating of perceived exertion (RPE) were not different (p>0.05) between MASK and NO-MASK conditions. Conclusions. Incremental exercise test performance is not adversely affected by RGC and analysis equipment, at least in short duration progressive treadmill exercise. Respiratory gas analysis during exercise testing for diagnostic, performance assessment or training prescription purposes would appear to be unaffected by RGC systems.


2018 ◽  
Vol 39 (04) ◽  
pp. 304-313
Author(s):  
Perrine Truong ◽  
Gregoire Millet ◽  
Boris Gojanovic

AbstractThis study aimed to investigate the differences in maximal oxygen uptake (V̇O2max) and submaximal thresholds between a standard graded exercise test (GXT) and a perceptually regulated graded exercise test (PRGXT) in trained runners. Eleven well-trained middle- to long-distance runners performed both tests in a randomized order. PRGXT used incremental “clamps” of rating of perceived exertion (RPE) over 10×1-min stages on an automated treadmill equipped with a sonar sensor allowing them to change their running speed instantly and in a natural way. GXT used fixed 1 km.h−1 increment every minute. Ventilatory threshold (VT) and respiratory compensation point (RCP) were determined using ventilatory equivalents. No differences were found in V̇O2max (68.0 (5.3) vs. 69.5 (5.9) ml·min−1·kg−1, p=0.243), minute ventilation (V̇E) (159.4 (35.0) vs. 162.4 (33.7) l·min−1, p=0.175), heart rate (HR) (188.4 (6.9) vs. 190.7 (5.2) bpm, p=0.254) and speed (21.0 (1.7) vs. 21.1 (2.3) km·h-1, p=0.761) between GXT and PRGXT. At VT, there were no significant differences between GXT and PRGXT for any outcome variables. For 8 of 11 subjects, it was not possible to determine RCP from ventilatory equivalent in PRGXT. GXT appears more relevant for a comprehensive gas analysis in trained runners.


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