Peroxisome proliferator-activated receptor α activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines

2008 ◽  
Vol 43 (7) ◽  
pp. 538-549 ◽  
Author(s):  
Hiroshi Oshio ◽  
Takaaki Abe ◽  
Tohru Onogawa ◽  
Hideo Ohtsuka ◽  
Takeaki Sato ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bile Acid ◽  
Cell Lines ◽  
Gene Transcription ◽  
Peroxisome Proliferator ◽  
Acid Transport ◽  
Human Colorectal Cancer ◽  
Peroxisome Proliferator Activated Receptor ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Lines

scholarly journals Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death

2021 ◽  
pp. 1-10
Author(s):  
Paulo Roberto Del Valle ◽  
Samir Andrade Mendonça ◽  
Fernanda Antunes ◽  
Aline Hunger ◽  
Rodrigo E Tamura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Gene Transfer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Interferon Beta ◽  
Human Colorectal Cancer ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Lines ◽  
Beta Gene

Action of a library of O-glycosylation inhibitors on the growth of human colorectal cancer cells in culture

2005 ◽  
Vol 33 (4) ◽  
pp. 721-723 ◽  
Author(s):  
G. Patsos ◽  
V. Hebbe-Viton ◽  
R. San Martin ◽  
C. Paraskeva ◽  
T. Gallagher ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cell Lines ◽  
Growth Patterns ◽  
Limited Information ◽  
Human Colorectal Cancer ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cells ◽  
Colorectal Cancer Cell Lines

O-glycosylation is thought to play a significant role in the regulation of cell growth. However, only limited information is available, and few specific and selective inhibitors have been found. We have synthesized a library of O-glycosylation inhibitors based on benzyl-O-N-acetyl-D-galactosamine. These inhibitors were tested with an established series of human colorectal cancer cell lines, which model the adenoma-carcinoma sequence. Cancer cells were incubated with the inhibitors, and examined for cell growth patterns, and cellular and subcellular glycosylation using a range of lectins with confocal microscopy. The specificity of O-glycan inhibition was confirmed for the library, relative to other forms of glycosylation. All inhibitors tested resulted in smaller cell yields. However, a differential effect on O-glycosylation was detected using the lectins showing variation of localization at a subcellular level in the various cell lines. Further differential action of the inhibitor library was observed for apoptosis and on the cell cycle with the cell lines tested. This work demonstrates that O-glycosylation is closely involved in the regulation of cell growth in colorectal cancer cells and that the generation of a library of low-molecular-mass inhibitors offers a valuable means of examining this regulation at the molecular level.

scholarly journals PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas

2018 ◽  
Vol 144 (4) ◽  
pp. 767-776 ◽  
Author(s):  
Christian H. Klein ◽  
Dina C. Truxius ◽  
Holger A. Vogel ◽  
Jana Harizanova ◽  
Sandip Murarka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Colorectal Cancer Cell ◽  
Human Colorectal Cancer ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Lines

The human novel gene, UBE2Q1, is expressed in human colorectal cancer cell lines and overexpressed in colorectal cancer tissue

2011 ◽  
Vol 44 (13) ◽  
pp. S69-S70
Author(s):  
Shafiee Sayed Mohammad ◽  
Seghatoleslam Atefeh ◽  
Nikseresht Mohsen ◽  
Alizadeh Naeeni Mahvash ◽  
Monabati Ahmad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Colorectal Cancer Cell ◽  
Cancer Tissue ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Tissue ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Lines
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