Hepatoprotective and cytotoxicity properties of aqueous extract of Glycyrrhiza glabra in Wistar rats fed with high-fat diet

2019 ◽  
Vol 28 (5) ◽  
pp. 1305-1312 ◽  
Author(s):  
Samaneh Goorani ◽  
Hassan Morovvati ◽  
Niloofar Seydi ◽  
Maryam Almasi ◽  
Amir Amiri-Paryan ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Glycyrrhiza Glabra ◽  
High Fat

Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet

2018 ◽  
Vol 28 (5) ◽  
pp. 1197-1203 ◽  
Author(s):  
Mohammad Mahdi Zangeneh ◽  
Saman Salmani ◽  
Akram Zangeneh ◽  
Reza Khedri ◽  
Mohammad Saeid Zarei
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat ◽  
Biochemical Effects ◽  
Tragopogon Graminifolius ◽  
Liver Tissues

scholarly journals Evaluation of antihyperlipidemic activity of ethanolic root extract of Glycyrrhiza glabra Linn.

2018 ◽  
Vol 8 (6-s) ◽  
pp. 120-124 ◽  
Author(s):  
Priya Tyagi ◽  
Satish Kumar Sharma ◽  
Pawan Kumar
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Conventional Medicine ◽  
Glycyrrhiza Glabra ◽  
Root Extract ◽  
Dependent Manner ◽  
High Fat ◽  
Standard Drug ◽  
Antihyperlipidemic Activity ◽  
Ethanolic Extracts

Glycyrrhiza glabra Linn. is an Indian medicinal plant demonstrated to exert multiple health cures. This plant grows naturally in tropical, subtropical and temperate regions. It is traditionally used as anti-acne, anti-arthritic, anti-convulsant, anti-diabetic, anti-microbial, anti inflammatory, wound healing, anti-oxidant, anti-platelet, anti-stress and nootropic, anti-viral, diuretic and gastroprotective. The antihyperlipidemic effect of ethanolic root extracts of Glycyrrhizaglabrawas studied in wistar rats using High Fat Diet (FD) induced hyperlipidemic model, at the doses of 400 mg/kg body weight. The efficacy of extract was compared with standard drug simvastatin. The ethanolic extracts, significantly decreased the serum lipid profile level in a dose dependent manner in wistar rats. Ethanolic extracts at 400 mg/kg have shown significant antihyperlipidemic action. These results support the fact that this plant is used traditionally as antihyperlipidemic. The study will help in exploring new plant source as an antihyperlipiedemic agent which can minimize the risk and side effects as compared to that of conventional medicine.  Keywords: Glycyrrhizaglabra, Antihyperlipidemic Activity, Simvastatin, High Fat Diet (FD) induced hyperlipidemic model.

scholarly journals Ameliorative Effects of Aqueous Extract of Date Palm Fruits (phoenix dactylifera) on high fat diet- induced Liver Damage in Adult Wistar Rats

2021 ◽  
Vol 25 (3) ◽  
pp. 327-331
Author(s):  
P.O. Onyilo ◽  
S.O. Innih ◽  
G. Ihemeson ◽  
L.U. Ogereka ◽  
S.M. Nweke ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Liver Damage ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Date Palm ◽  
Wistar Rat ◽  
Phoenix Dactylifera ◽  
High Dose ◽  
High Fat ◽  
Standard Drug

Elevated cholesterol level is a major cause of disease burden in developing Nations. This study seeks to evaluate the ameliorative and hepatoprotective potentials of aqueous extract of date palm (Phoenix dactylifera) on high fat diet-induced liver damage. Thirty (30) adult wistar rats weighing 110-180g were randomly divided into six group of five animals each, group A served as control while B was exposed to high fat diet only (using margarine brand); Groups C, D and E were given high fat diet with co-treated with the extract at low, medium and high doses respectively while group F was received the drug Atrovastin as a gold standard to enable comparative effects of date palm administration. At the end of the treatment period, the animals were anaesthetized using chloroform blood samples were collected via cardiac puncture to investigate the activities of liver enzymes, and liver tissue was harvested through a midline incision for histological analysis. There were evidence of vascular congestion and periportal infiltration in rats given margarineonly indicative of hepatocellular disruption. Animals that received moderate to high dose of the fruit extract show mild to total reversal of the damaged liver cells and activation of kupffer cells with concurrent changes in serum albumin level. Aqueous extract of phoenix dactylifera was seen to ameliorate the fat induced liver damage with notable changes in hepatocyte configuration as observed when treated with standard drug. Keywords: Phoenix dactylifera, Hyperlipedermia, Liver, Wistar rat

scholarly journals Effect of an aqueous extract of Chrysobalanus icaco on the adiposity of Wistar rats fed a high-fat diet

2020 ◽  
Author(s):  
Keciany Alves ◽  
Heloisa Helena Pessoa Portela-de-Sá ◽  
Paula Alexandre de Freitas ◽  
Yuri de Abreu Gomes-Vasconcelos ◽  
Renata Prado Vasconcelos ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat

Effect of aqueous extract of Allium saralicum R.M. Fritsch on fatty liver induced by high-fat diet in Wistar rats

2018 ◽  
Vol 28 (5) ◽  
pp. 1205-1211 ◽  
Author(s):  
Rohallah Moradi ◽  
Majid Hajialiani ◽  
Saman Salmani ◽  
Maryam Almasi ◽  
Akram Zangeneh ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat

The effects of the aqueous extract and residue of Matcha on the antioxidant status and lipid and glucose levels in mice fed a high-fat diet

2016 ◽  
Vol 7 (1) ◽  
pp. 294-300 ◽  
Author(s):  
Ping Xu ◽  
Le Ying ◽  
Gaojie Hong ◽  
Yuefei Wang
Keyword(s):  
Green Tea ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Antioxidant Status ◽  
High Fat ◽  
Glucose Levels

Matcha is a kind of powdered green tea produced by grinding with a stone mill.

Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high‐fat diet‐induced obesity in male Wistar rats

Andrologia ◽  
2021 ◽  
Author(s):  
Comfort Abisola Oladele ◽  
Christopher Oloruntoba Akintayo ◽  
Olabimpe Caroline Badejogbin ◽  
Adesola Adedotun Oniyide ◽  
Adams Olalekan Omoaghe ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Endocrine Dysfunction ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Male Wistar Rats

Particular Matter of Motor Vehicle Exposure and High-Fat Diet Effects on Kidney Histopathology, Creatinine, and Malondialdehyde (MDA) Levels in Wistar Rats

2021 ◽  
Vol 5 (3) ◽  
pp. 124-128
Author(s):  
Rizka Veni ◽  
Awal Prasetyo ◽  
Muflihatul Muniroh
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Motor Vehicle ◽  
Histopathological Change ◽  
Normal Diet ◽  
Control Group ◽  
High Fat ◽  
Control Group Design ◽  
Treatment Groups ◽  
Significant Difference

This study aims to analyze the effect of combination of motor vehicle particular matter exposure and high-fat diet in kidney histopathology, creatinine levels, and MDA levels in Wistar rats. This study used a posttest-only control group design. Eighteen healthy male Wistar rats were divided into three groups. The intervention groups received motor vehicle fume exposure for 100 s with normal diet (X1) or high-fat diet (X2), and the control group received no exposure (C). Data analysis was processed with a SPSS 25.0 computer program by using the one-way ANOVA test followed by post hoc LSD. The degree of kidney histopathological damage showed significant differences between the X1 and X2 groups when compared with the control group (p < 0.05). The results of the creatinine level examination found a significant difference between the X2 and C groups (p < 0.05) and the treatment groups X1 and X2 (p < 0.05). The results of kidney MDA level examination showed a significant difference between the treatment groups (X1 and X2) and the control group (p < 0.05). The combination of particular matter of motor vehicle fumes exposure and high-fat diet could induce kidney damage through histopathological change and increased creatinine levels and kidney MDA levels in Wistar rats.

Hepatoprotective effect of coffee pulp aqueous extract combined with simvastatin against hepatic steatosis in high-fat diet-induced obese rats

2019 ◽  
Vol 54 ◽  
pp. 568-577 ◽  
Author(s):  
Atcharaporn Ontawong ◽  
Oranit Boonphang ◽  
Tipthida Pasachan ◽  
Acharaporn Duangjai ◽  
Anchalee Pongchaidecha ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Hepatoprotective Effect ◽  
High Fat ◽  
Coffee Pulp ◽  
Obese Rats
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