Anxious depression as a clinically relevant subtype of pediatric major depressive disorder

2019 ◽  
Vol 126 (9) ◽  
pp. 1217-1230 ◽  
Author(s):  
Isabelle Häberling ◽  
Noemi Baumgartner ◽  
Sophie Emery ◽  
Paola Keller ◽  
Michael Strumberger ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Anxious Depression

scholarly journals Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder

2016 ◽  
Vol 13 (3) ◽  
pp. 321 ◽  
Author(s):  
Ji Hyun Baek ◽  
Hee-Jin Kim ◽  
Maurizio Fava ◽  
David Mischoulon ◽  
George I Papakostas ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Venous Blood ◽  
Major Depressive ◽  
Anxious Depression ◽  
Blood Basophil

Characterising anxiety in major depressive disorder and its use in predicting antidepressant treatment outcome: An iSPOT-D report

2019 ◽  
Vol 53 (8) ◽  
pp. 782-793 ◽  
Author(s):  
Taylor A Braund ◽  
Donna M Palmer ◽  
Leanne M Williams ◽  
Anthony WF Harris
Keyword(s):  
Major Depressive Disorder ◽  
Treatment Outcome ◽  
Depressive Disorder ◽  
Anxiety Disorders ◽  
Clinical Features ◽  
Antidepressant Treatment ◽  
Anxiety Symptoms ◽  
Poor Agreement ◽  
Major Depressive ◽  
Anxious Depression

Objective: Major depressive disorder commonly co-occurs with one or more anxiety disorders or with clinically significant levels of anxiety symptoms. Although evidence suggests that anxious forms of depression are prognostic of poorer antidepressant outcomes, there is no clear definition of anxious depression, and inferences about clinical outcomes are thus limited. Our objective was to compare and evaluate definitions of anxious depression and anxiety-related scales according to clinical and antidepressant outcome criteria. Method: A total of 1008 adults with a current diagnosis of single-episode or recurrent, nonpsychotic, major depressive disorder were assessed at baseline on clinical features. Participants were then randomised to one of three antidepressants and reassessed at 8 weeks regarding remission and response of the 17-item Hamilton Rating Scale Depression (HRSD17) and the 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR16). Anxious depression was defined as major depressive disorder with one or more anxiety disorders or major depressive disorder with a HRSD17 anxiety/somatisation factor score ⩾7. Anxiety-related scales included the HRSD17 anxiety/somatisation factor and the 42-item Depression Anxiety Stress Scales (DASS42) anxiety and stress subscales. Results: Anxious depression definitions showed poor agreement (κ = 0.15) and the HRSD17 anxiety/somatisation factor was weakly correlated with both DASS42 anxiety ( r = 0.24) and stress subscales ( r = 0.20). Anxious depression definitions were also associated with few impairments on clinical features and did not predict poorer antidepressant treatment outcome. However, higher DASS42 anxiety predicted poorer HRSD17 and QIDS-SR16 remission, and item-level analysis found higher scores on items 9 (situational anxiety) and 23 (somatic anxiety) of the DASS42 predicted poorer treatment outcome, even after adjusting for covariates and multiple comparisons. Conclusion: Common definitions of anxious depression show poor agreement and do not predict poorer treatment outcome. Anxiety symptoms may be better characterised dimensionally using DASS42 when predicting treatment outcome.

EXTENDED RELEASE QUETIAPINE FUMARATE IN MAJOR DEPRESSIVE DISORDER: ANALYSIS IN PATIENTS WITH ANXIOUS DEPRESSION

2012 ◽  
Vol 29 (7) ◽  
pp. 574-586 ◽  
Author(s):  
Michael E. Thase ◽  
Koen Demyttenaere ◽  
Willie R. Earley ◽  
Urban Gustafsson ◽  
Mattias Udd ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Extended Release ◽  
Major Depressive ◽  
Quetiapine Fumarate ◽  
Anxious Depression

Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D

2004 ◽  
Vol 34 (7) ◽  
pp. 1299-1308 ◽  
Author(s):  
MAURIZIO FAVA ◽  
JONATHAN E. ALPERT ◽  
CHERYL N. CARMIN ◽  
STEPHEN R. WISNIEWSKI ◽  
MADHUKAR H. TRIVEDI ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Psychiatric Symptoms ◽  
Major Depressive ◽  
Anxious Depression ◽  
Clinical Correlates ◽  
Before And After ◽  
Severity Of Depression ◽  
Symptom Patterns

Background. Anxious depression, defined as Major Depressive Disorder (MDD) with high levels of anxiety symptoms, may represent a relatively common depressive subtype, with distinctive features.Objective. The objective of this study was to determine the prevalence of anxious depression and to define its clinical correlates and symptom patterns.Method. Baseline clinical and sociodemographic data were collected on 1450 subjects participating in the STAR*D study. A baseline Hamilton Rating Scale for Depression (HAM-D) Anxiety/Somatization factor score of [ges ]7 was considered indicative of anxious depression. The types and degree of concurrent psychiatric symptoms were measured using the Psychiatric Diagnostic Screening Questionnaire (PDSQ), by recording the number of items endorsed by study participants for each diagnostic category. MDD symptoms were assessed by clinical telephone interview with the 30-item Inventory of Depressive Symptomatology (IDS-C30).Results. The prevalence of anxious depression in this population was 46%. Patients with anxious MDD were significantly more likely to be older, unemployed, less educated, more severely depressed, and to have suicidal ideation before and after adjustment for severity of depression. As far as concurrent psychiatric symptoms are concerned, patients with anxious depression were significantly more likely to endorse symptoms related to generalized anxiety, obsessive compulsive, panic, post-traumatic stress, agoraphobia, hypochondriasis, and somatoform disorders before and after adjustment for severity of depression. Anxious-depression individuals were also significantly less likely to endorse IDS-C30 items concerning atypical features, and were significantly more likely to endorse items concerning melancholic/endogenous depression features.Conclusion. This study supports specific clinical and sociodemographic correlates of MDD associated with high levels of anxiety (anxious depression).

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