Population-based study of the relationship between medial meniscus radial displacement, determined by use of ultrasound screening, and knee pain

AbstractWhile studies suggest potential influences of childhood adversities on obesity development in adulthood, less is known about the short-term association in children. We examined the association between a wide range of life events experienced in the first ten years of life (including maltreatment and milder adversities) and body composition in 5333 ten-year old Dutch children. In structured interviews, mothers retrospectively reported on their children’s experience of 24 events. BMI was calculated, and fat mass index and fat free mass index were determined by dual-x-ray absorptiometry scanning. Linear regressions showed that, unadjusted, a higher number of life events was associated with higher BMI and body composition. However, associations attenuated to non-significance after adjustment for covariates. Similar findings were observed for maltreatment and milder life events. Thus, the number of experienced life events was not associated with body composition in middle childhood. Rather, other factors, like socioeconomic conditions, accounted for the relationship between life events and weight development in children.

Download Full-text

The Relationship between Thyroid Function and Depressive Symptoms—the FIN-D2D Population-Based Study

Clinical Medicine Insights Endocrinology and Diabetes ◽

10.4137/cmed.s24111 ◽

2015 ◽

Vol 8 ◽

pp. CMED.S24111 ◽

Cited By ~ 4

Author(s):

Juha Saltevo ◽

Hannu Kautiainen ◽

Pekka Mäntyselkä ◽

Antti Jula ◽

Sirkka Keinänen-Kiukaanniemi ◽

...

Keyword(s):

Regression Analysis ◽

Depressive Symptoms ◽

Thyroid Function ◽

Participation Rate ◽

Population Based ◽

Thyroid Stimulating Hormone ◽

Free Triiodothyronine ◽

Population Based Study ◽

The Mean ◽

The Relationship

The association between thyroid function and depression is controversial. Both conditions express many similar symptoms, but the studies done give conflicting results. This study draws on a random, population-based sample of 4500 subjects aged 45–75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depressive symptoms were 1.92/1.97 mU/L, 13.1/13.1 pmol/L, and 3.91/3.87 pmol/L (NS), respectively. In men, the levels were 1.87/1.94 mU/L, 13.5/13.7 pmol/L, and 4.18/4.12 pmol/L (NS), respectively. In multiple regression analysis, TSH had no relationship to BDI-21 total score. We found no association between depressive symptoms and thyroid values.

Download Full-text

Routine Ultrasound Screening in the Third Trimester: A Population-Based Study

Obstetrical & Gynecological Survey ◽

10.1097/01.ogx.0000206346.89456.0a ◽

2006 ◽

Vol 61 (4) ◽

pp. 228-229

Author(s):

Kerstin Sylvan ◽

Elsa Lena Ryding ◽

H??kan Rydhstroem

Keyword(s):

Population Based ◽

Ultrasound Screening ◽

Third Trimester ◽

Population Based Study ◽

The Third

Download Full-text

Cost and outcomes of the ultrasound screening program for birth defects over time: a population-based study in France

BMJ Open ◽

10.1136/bmjopen-2019-036566 ◽

2020 ◽

Vol 10 (7) ◽

pp. e036566

Author(s):

Clément Ferrier ◽

Babak Khoshnood ◽

Ferdinand Dhombres ◽

Hanitra Randrianaivo ◽

Isabelle Perthus ◽

...

Keyword(s):

Health Insurance ◽

Cost Effectiveness ◽

Birth Defects ◽

Screening Programme ◽

Population Based ◽

Ultrasound Screening ◽

Cost Effectiveness Ratio ◽

Population Based Study ◽

Prenatal Detection ◽

The Cost

ObjectiveTo assess trends in the average costs and effectiveness of the French ultrasound screening programme for birth defects.DesignA population-based study.SettingNational Public Health Insurance claim database.ParticipantsAll pregnant women in the ‘Echantillon Généraliste des Bénéficiaires’, a permanent representative sample of 1/97 of the individuals covered by the French Health Insurance System.Main outcomes measuresTrends in the costs and in the average cost-effectiveness ratio (ACER) of the screening programme (in € per case detected antenatally), per year, between 2006 and 2014. incremental cost-effectiveness ratio (ICER) from 1 year to another were also estimated. We assessed costs related to the ultrasound screening programme of birth defects excluding the specific screening of Down’s syndrome. The outcome for effectiveness was the prenatal detection rate of birth defects, assessed in a previous study. Linear and logistic regressions were used to analyse time trends.ResultsDuring the study period, there was a slight decrease in prenatal detection rates (from 58.2% in 2006 to 55.2% in 2014; p=0.015). The cost of ultrasound screening increased from €168 in 2006 to €258 per pregnancy in 2014 (p=0.001). We found a 61% increase in the ACER for ultrasound screening during the study period. ACERs increased from €9050 per case detected in 2006 to €14 580 per case detected in 2014 (p=0.001). ICERs had an erratic pattern, with a strong tendency to show that any increment in the cost of screening was highly cost ineffective.ConclusionEven if the increase in costs may be partly justified, we observed a diminishing returns for costs associated with the prenatal ultrasound screening of birth defects, in France, between 2006 and 2014.

Download Full-text