scholarly journals Systematic review and meta-analysis of diagnostic methods for occlusal surface caries

2021 ◽  
Author(s):  
Svetlana Kapor ◽  
Mila Janjic Rankovic ◽  
Yegane Khazaei ◽  
Alexander Crispin ◽  
Ina Schüler ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Diagnostic Methods ◽  
Laser Fluorescence ◽  
Caries Detection ◽  
Detection Level ◽  
Dentin Caries

Abstract Aim This systematic review and meta-analysis aimed to assess the diagnostic performance of commonly used methods for occlusal caries diagnostics, such as visual examination (VE), bitewing radiography (BW) and laser fluorescence (LF), in relation to their ability to detect (dentin) caries under clinical and laboratory conditions. Materials and methods A systematic search of the literature was performed to identify studies meeting the inclusion criteria using the PIRDS concept (N = 1090). A risk of bias (RoB) assessment tool was used for quality evaluation. Reports with low/moderate RoB, well-matching thresholds for index and reference tests and appropriate reporting were included in the meta-analysis (N = 37; 29 in vivo/8 in vitro). The pooled sensitivity (SE), specificity (SP), diagnostic odds ratio (DOR) and areas under ROC curves (AUCs) were computed. Results SP ranged from 0.50 (fibre-optic transillumination/caries detection level) to 0.97 (conventional BW/dentine detection level) in vitro. AUCs were typically higher for BW or LF than for VE. The highest AUC of 0.89 was observed for VE at the 1/3 dentin caries detection level; SE (0.70) was registered to be higher than SP (0.47) for VE at the caries detection level in vivo. Conclusion The number of included studies was found to be low. This underlines the need for high-quality caries diagnostic studies that further provide data in relation to multiple caries thresholds. Clinical relevance VE, BW and LF provide acceptable measures for their diagnostic performance on occlusal surfaces, but the results should be interpreted with caution due to the limited data in many categories.

scholarly journals Systematic review and meta-analysis of diagnostic studies of proximal surface caries

2021 ◽  
Author(s):  
Mila Janjic Rankovic ◽  
Svetlana Kapor ◽  
Yegane Khazaei ◽  
Alexander Crispin ◽  
Ina Schüler ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Laser Fluorescence ◽  
Caries Detection ◽  
Index Test ◽  
Dentin Caries ◽  
Diagnostic Studies ◽  
Caries Diagnostics

Abstract Aim This systematic review and meta-analysis aimed to assess the diagnostic accuracy and reliability of commonly used caries detection methods for proximal caries diagnostics. Visual examination (VE), bitewing radiography (BWR), laser fluorescence (LF), and fibre-optic transillumination (FOTI) were considered in detail. Material and methods PRISMA guidelines for the reporting of systematic reviews and meta-analyses were applied. The mnemonic PIRDS (problem, index test, reference test, diagnostic and study type) concept was used to guide the literature search. Next, studies that met the inclusion criteria were stepwise selected and evaluated for their quality with a risk of bias (RoB) assessment tool. Studies with low/moderate bias and sufficient reporting were considered for meta-analysis. The pooled sensitivity (SE), specificity (SP), diagnostic odds ratio (DOR), and area under the ROC curve (AUC) were calculated. Results From 129 studies meeting the selection criteria, 31 in vitro studies and five clinical studies were finally included in the meta-analysis. The AUC values for in vitro VE amounted to 0.84 (caries detection) and 0.85 (dentin caries detection). BWR ranged in vitro from 0.55 to 0.82 (caries detection) and 0.81–0.92 (dentin caries detection). LF showed higher AUC values for overall caries detection (0.91) and dentin caries detection (0.83) than did other methods. Clinical data are limited. Conclusion The number of diagnostic studies with low/moderate RoB was found to be low and indicates a need for high-quality, well-designed caries diagnostic studies. Clinical relevance BWR and LF showed good diagnostic performance on proximal surfaces. However, because of the low number of includable clinical studies, these data should be interpreted with caution.

Laser fluorescence of caries detection in permanent teeth in vitro: a systematic review and meta-analysis

2016 ◽  
Vol 9 (4) ◽  
pp. 213-224 ◽  
Author(s):  
Maria I Rosa ◽  
Vilson S Schambeck ◽  
Eduardo R Dondossola ◽  
Maria CM Alexandre ◽  
Lisiane Tuon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Laser Fluorescence ◽  
Caries Detection ◽  
Permanent Teeth

scholarly journals Aplicação do Laser na Cariologia: diagnóstico, prevenção e tratamento

2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Ana Luzia Araújo Batista ◽  
Thamyres Maria Silva Simões ◽  
Maria das Graças Barbosa da Silva ◽  
Maria Helena Chaves de Vasconcelos Catão
Keyword(s):  
Systematic Review ◽  
Laser Irradiation ◽  
Primary Teeth ◽  
Er:Yag Laser ◽  
Meta Analysis ◽  
Laser Fluorescence ◽  
Caries Detection ◽  
Permanent Teeth ◽  
Topical Fluoride

Nas últimas décadas, um dos grandes avanços na Área da Saúde foi o desenvolvimento dos aparelhos de Laser, que possibilitou uma nova abordagem nos procedimentos odontológicos. A Laserterapia tem diversas aplicabilidades na Cariologia, seja como método de diagnóstico, como auxiliar nas medidas preventivas ou como tratamento da cárie dentária. Portanto, o objetivo desta revisão é proporcionar uma leitura atualizada da aplicabilidade da Laserterapia na Cariologia e, para tanto, foi realizada uma revisão literária sistematizada, na base de dados MEDLINE – Pubmed, abrangendo os últimos anos. Mediante esse estudo literário e considerando a evolução dos estudos científicos, ainda existem controvérsias a respeito da eficácia clínica do Laser na Cariologia.Descritores: Lasers; Cárie Dentária; Flúor.ReferênciasSichani AV, Javadinejad S, Ghafari R. Diagnostic value of DIAGNOdent in detecting caries under composite restorations of primary molars. Dent Res J. 2016;13(4):327-32.Montedori A, Abraha I, Orso M, D'errico PG, Pagano S, Lombardo G. Lasers for caries removal in deciduous and permanent teeth. Cochrane Database Syst Rev. 2016;26(9):CD010229.Nagata JY, Hioka N, Kimura E, Batistela VR, Terada RS, Graciano AX et al. Antibacterial photodynamic therapy for dental caries: evaluation of the photosensitizers used and light source properties. Photodiagnosis Photodyn Ther. 2012;9(2):122-31.Bahrololoomi Z, Fotuhi  Ardakani F, Sorouri M. In vitro comparison of the effects of diode laser and co2 laser on topical fluoride uptake in primary teeth. J Dent (Tehran). 2015;12(8):585-91.Nokhbatolfoghahaie H, Alikhasi M, Chiniforush N, Khoei F, Safavi N, Yaghoub Zadeh B. Evaluation of Accuracy of DIAGNOdent in Diagnosis of Primary and Secondary Caries in Comparison to Conventional Methods. J Lasers Med Sci. 2013; 4(4):159-67.Melo M, Pascual A, Camps I, Del Campo Á, Ata-Ali J. Caries diagnosis using light fluorescence devices in comparison with traditional visual and tactile evaluation: a prospective study in 152 patients. Odontology. 2017;105(3):283-90.Gimenez T, Braga MM, Raggio DP, Deery C, Ricketts DN, Mendes FM. Fluorescence-based methods for detecting caries lesions: systematic review, meta-analysis and sources of heterogeneity. PLoS One. 2013;8(4):e60421.Kositbowornchai S, Sukanya C, Tidarat T, Chanoggarn T. Caries detection under composite restorations by laser fluorescence and digital radiography. Clin Oral Investig. 2013; 17(9):2079-84.Rosa MI, Schambeck VS, Dondossola ER, Alexandre MC, Tuon L, Grande AJ, Hugo F. Laser fluorescence of caries detection in permanent teeth in vitro: a systematic review and meta-analysis. J Evid Based Med. 2016;  9(4):213-24.Heravi F, Ahrari F, Mahdavi M, Basafa S. Comparative evaluation of the effect of Er:YAG laser and low level laser irradiation combined with CPP-ACPF cream on treatment of enamel caries. J Clin Exp Dent. 2014;6(2):e121-26.Mang TS, Tayal DP, Baier R. Photodynamic therapy as an alternative treatment for disinfection of bacteria in oral biofilms. Lasers Surg Med. 2012;44(7):588-96.Fornaini C, Brulat N, Milia G, Rockl A, Rocca JP. The use of sub-ablative Er:YAG laser irradiation in  prevention of dental caries during orthodontic treatment. Laser Ther. 2014;23(3):173-81.Karandish M. The efficiency of laser application on the enamel surface: a systematic review. J Lasers Med Sci. 2014;5(3):108-14.Twetman S, Axelsson S, Dahlén G, Espelid I, Mejàre I, Norlund A et al. Adjunct methods for caries detection: a systematic review of literature. Acta Odontol Scand. 2013;71(3-4):388-97.Bahrololoomi Z, Lotfian M. Effect of diode laser irradiation combined with topical fluoride on enamel microhardness of primary teeth. J Dent (Tehran). 2015;12(2):85-9.Ramos-Oliveira TM, Ramos TM, Esteves-Oliveira M, Apel C, Fischer H, Eduardo CP et al. Potential of CO2 lasers (10.6 µm) associated with fluorides in inhibiting human enamel erosion. Braz Oral Res. 2014;28(1):1-6.Souza-Gabriel AE, Turssi CP, Colucci V, Tenuta LM, Serra MC, Corona SA. In situ study of the anticariogenic potential of fluoride varnish combined with CO2 laser on enamel. Arch Oral Biol. 2015;60(6):804-10.

scholarly journals Comparison of novel and established caries diagnostic methods: a clinical study on occlusal surfaces

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Friederike Litzenburger ◽  
Gerrit Schäfer ◽  
Reinhard Hickel ◽  
Jan Kühnisch ◽  
Katrin Heck
Keyword(s):  
Diagnostic Performance ◽  
Diagnostic Methods ◽  
Laser Fluorescence ◽  
The Other ◽  
Caries Detection ◽  
Reference Standard ◽  
Occlusal Caries ◽  
Enamel Caries ◽  
Dentin Caries ◽  
Occlusal Caries Detection

Abstract Background The purpose of this prospective clinical diagnostic study with validation was to compare the diagnostic accuracy of near-infrared transillumination (NIRT), laser fluorescence measurement (LF), alternating current impedance spectroscopy (ACIS) and their combinations as adjunct methods to visual examination (VE) for occlusal caries detection using a hybrid reference standard. Methods Ninety-six first and second non-cavitated permanent molars from 76 individuals (mean age 24.2) were investigated using (VE) (ICDAS) and bitewing radiography (BWR), as well as NIRT, LF and ACIS. The findings of BWR and NIRT were evaluated by two examiners while the other examinations were conducted by one calibrated dentist. The hybrid reference standard consisted of non-operative validation based on the results of VE and BWR and operative validation. Statistical analysis included cross-tabulations, calculation of sensitivity, specificity and area under the receiver operating characteristic curve at three diagnostic thresholds: caries in general, enamel caries and dentin caries. Results NIRT, LF and ACIS exhibited high sensitivity for caries in general [1.00 (1.00–1.00), 0.77 (0.65–0.88), 0.75 (0.63–0.87)) and for dentin caries (0.97 (0.91–1.03), 0.76 (0.76–0.90), 0.64 (0.47–0.80)]. Sensitivity values for enamel caries were weak (0.21, 0.11, 0.37). Specificity values did not fall below 0.65 (NIRT) for all categories and methods, except for NIRT at the caries detection threshold (0.27). A combination of LF and ACIS with VE improved the diagnostic performance at the overall and the enamel caries threshold. The other methods showed fair to excellent discrimination at the overall caries threshold (NIRT 0.64, LF 0.89 and ACIS 0.86) and acceptable discrimination at the dentin caries threshold (NIRT 0.82, LF 0.81 and ACIS 0.79). AUROC for enamel caries exhibited the weakest discrimination. Accuracy was 65.6% for VE, 69.8% for BWR, 50.0% for NIRT, 53.1% for LF and 74.0% for ACIS. Reliability assessment for BWR and NIRT showed at least substantial agreements for all analyses. Conclusions The methods, NIRT, LF and ACIS, revealed different potential but no impeccable performance for occlusal caries detection. All are suitable instruments to detect hidden carious lesion in dentin. As auxiliaries to VE, LF and ACIS showed an increase in diagnostic performance.

scholarly journals Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 506
Author(s):  
Bernardo Romão ◽  
Ana Luísa Falcomer ◽  
Gabriela Palos ◽  
Sandra Cavalcante ◽  
Raquel Braz Assunção Botelho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Glycemic Index ◽  
Resistant Starch ◽  
Web Of Science ◽  
Meta Analysis ◽  
Gluten Free ◽  
Inclusion Criteria ◽  
Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

scholarly journals Enhancement of Chondrogenesis in Hypoxic Precondition Culture: A Systematic Review

2021 ◽  
Vol 9 (F) ◽  
pp. 492-504
Author(s):  
Sholahuddin Rhatomy ◽  
Riky Setyawan ◽  
Michael Aaron Romulo
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Oxygen Level ◽  
Hypoxic Precondition ◽  
Online Library

BACKGROUND: Cartilage tear has begun to be treated with stem cells. However, stem cell oxygen level culture has not been evaluated for the best environment to enhance chondrogenesis. AIM: The purpose of this review is to focus on the hypoxic oxygen level of stem cells culture as a treatment for cartilage tear. METHODS: A literature search was systemically conducted on PubMed (MEDLINE), OVID, EMBASE, the Cochrane Library, Scopus, Web of Science, Science Direct, Wiley Online Library, Google Scholar, and bibliography of selected articles with the terms (“culture”) AND (“stem cell” OR “mesenchymal stem cell” OR “MSC”) AND (“hypoxic” OR “hypoxia”) AND (“cartilage” OR “chondro*”) as the main keywords. A total of 438 articles were reviewed. Thirty-six articles were considered relevant for this systematic review. RESULTS: The result of this review supports stimulation effects of hypoxic oxygen level stem cell culture in chondrogenesis process. Most studies used 5% oxygen concentration for culture, both of in vivo and in vitro studies. Due to the heterogeneity nature of the included studies, meta-analysis was unable to be conducted. CONCLUSION: Hypoxia state seems to play an important role in chondrocytes proliferation, differentiation, and matrix production.

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