A systematic review and meta-analysis of spermatozoa cryopreservation, in vitro and in vivo fertility practices in water buffalo

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

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Comparison of in vivo and in vitro force decay of elastomeric chains/modules: a systematic review and meta analysis

Journal of the World Federation of Orthodontists ◽

10.1016/j.ejwf.2021.07.003 ◽

2021 ◽

Author(s):

Pushkar Andhare ◽

Sanjeev Datana ◽

Shiv Shankar Agarwal ◽

S.S. Chopra

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Force Decay ◽

Elastomeric Chains

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Enhancement of Chondrogenesis in Hypoxic Precondition Culture: A Systematic Review

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.5850 ◽

2021 ◽

Vol 9 (F) ◽

pp. 492-504

Author(s):

Sholahuddin Rhatomy ◽

Riky Setyawan ◽

Michael Aaron Romulo

Keyword(s):

Systematic Review ◽

Stem Cells ◽

Stem Cell ◽

Meta Analysis ◽

Cochrane Library ◽

Oxygen Level ◽

Hypoxic Precondition ◽

Online Library

BACKGROUND: Cartilage tear has begun to be treated with stem cells. However, stem cell oxygen level culture has not been evaluated for the best environment to enhance chondrogenesis. AIM: The purpose of this review is to focus on the hypoxic oxygen level of stem cells culture as a treatment for cartilage tear. METHODS: A literature search was systemically conducted on PubMed (MEDLINE), OVID, EMBASE, the Cochrane Library, Scopus, Web of Science, Science Direct, Wiley Online Library, Google Scholar, and bibliography of selected articles with the terms (“culture”) AND (“stem cell” OR “mesenchymal stem cell” OR “MSC”) AND (“hypoxic” OR “hypoxia”) AND (“cartilage” OR “chondro*”) as the main keywords. A total of 438 articles were reviewed. Thirty-six articles were considered relevant for this systematic review. RESULTS: The result of this review supports stimulation effects of hypoxic oxygen level stem cell culture in chondrogenesis process. Most studies used 5% oxygen concentration for culture, both of in vivo and in vitro studies. Due to the heterogeneity nature of the included studies, meta-analysis was unable to be conducted. CONCLUSION: Hypoxia state seems to play an important role in chondrocytes proliferation, differentiation, and matrix production.

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PTEN regulates arsenic-inducedn autophagy in PI3K/AKT/mTOR signaling pathway; A systematic review and meta-analysis of in vivo and in vitro studies

10.37766/inplasy2021.1.0012 ◽

2021 ◽

Author(s):

Fei Hang ◽

Rishalaiti Tayier ◽

Ang Li ◽

Yanjie Yuan ◽

Shunhua Wu

Keyword(s):

Systematic Review ◽

Signaling Pathway ◽

Meta Analysis ◽

Mtor Signaling ◽

In Vitro Studies ◽

Mtor Signaling Pathway

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Use of DIAGNOdent and VistaProof in diagnostic of Pre-Cavitated Caries Lesions—A Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm9010020 ◽

2019 ◽

Vol 9 (1) ◽

pp. 20 ◽

Cited By ~ 2

Author(s):

José Enrique Iranzo-Cortés ◽

José María Montiel-Company ◽

Teresa Almerich-Torres ◽

Carlos Bellot-Arcís ◽

José Manuel Almerich-Silla

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

A Value ◽

Published Evidence ◽

Meta Analyses ◽

Fail Safe ◽

Cavitated Lesions

Objective: To analyse the published evidence of the validity of DIAGNDOdent and VistaProof in diagnosing carious depths in pre-cavitated lesions. Material and methods: A systematic review was carried out after identifying a total of 184 articles, including 27 concerning the qualitative review and a subsequent meta-analysis. The quality of the studies was evaluated by using the QUADAS-2 tool. Results: For DIAGNOdent, the sensitivity value was 0.77, the specificity value was 0.75 and AUC was 0.81 for the global meta-analyses. In relation to subgroups, the values estimated 0.85, 0.76 and 0.86, respectively, for the in vivo group and 0.71, 0.75 and 0.83 for the in vitro group. For VistaProof, sensitivity was 0.81, specificity 0.75 and AUC had a value of 0.80 in the global meta-analysis. For the subgroups, these were considered at 0.75, 0.81 and 0.89, respectively, for the in vivo group and 0.91, 0.74 and 0.76 for the in vitro group. Neither case presented publication bias when analysing the funnel plot, the classic fail-safe number and Egger’s intercept. Conclusion: Both VistaProof and DIAGNOdent are valid as they offer a moderate to high diagnostic effectiveness for dentine depth in pre-cavitated lesions.

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Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/jpps31457 ◽

2020 ◽

Vol 23 ◽

pp. 462-469

Author(s):

Biswa Mohan Padhy ◽

Rashmi Ranjan Mohanty ◽

Smita Das ◽

Bikash Ranjan Meher

Keyword(s):

Systematic Review ◽

Therapeutic Potential ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Symptomatic Treatment ◽

Effect Model ◽

Usual Therapy

The current management of COVID-19 is mostly limited to general supportive care and symptomatic treatment. Ivermectin is a broad-spectrum anti-parasitic drug used widely for the treatment of onchocerciasis and lymphatic filariasis. Apart from its anti-parasitic effect it also exhibits antiviral activity against a number of viruses both in vitro and in vivo. Hence, we conducted this systematic review and meta-analysis to assess the currently available data on the therapeutic potential of ivermectin for the treatment of COVID‐19 as add on therapy. A total of 629 patients were included in the 4 studies and all were COVID-19 RT-PCR positive. Among them, 397 patients received ivermectin along with usual therapy. The random effect model showed the overall pooled OR to be 0.53 (95%CI: 0.29 to0.96) for the primary outcome (all-cause mortality) which was statistically significant (P=0.04). Similarly, the random effect model revealed that adding ivermectin led to significant clinical improvement compared to usual therapy (OR=1.98, 95% CI: 1.11 to 3.53, P=0.02). However, this should be inferred cautiously as the quality of evidence is very low. Currently, many clinical trials are on-going, and definitive evidence for repurposing this drug for COVID-19 patients will emerge only in the future.

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Mechanism of Action of Limonene in Tumor Cells: A Systematic Review and Metanalysis

Current Pharmaceutical Design ◽

10.2174/1381612826666201026152902 ◽

2020 ◽

Vol 26 ◽

Author(s):

Juliana de Vasconcelos Cerqueira Braz ◽

Fernanda Oliveira de Carvalho ◽

Daniele de Vasconcelos Cerqueira Meneses ◽

Fernanda Araújo Felipe Calixto ◽

Hericalizandra Santa Rosa Santana ◽

...

Keyword(s):

Systematic Review ◽

Tumor Regression ◽

Case Reports ◽

Meta Analysis ◽

Public Health Problem ◽

Major Public Health Problem ◽

Kappa Index ◽

Induced Apoptosis

Background: Cancer is a complex, multifactorial disease, and a major public health problem, as it is a leading cause of morbidity and mortality worldwide. Although treatments have significantly improved, there is a still a search for more effective drugs. One source for these are natural products (NPs). One NP that has shown anticancer activity is Limonene. However, the mechanisms of limonene's antiproliferative, anticancer and antineoplastic activity are not fully understood. Objective: The objective of this study is, therefore, to undertake a systematic review and meta-analysis of the literature on this subject. Methods: A comprehensive literature search was performed using the Scopus, MEDLINE-PubMed, Web of Science, and Science Direct databases using the keywords: "limonene", “cancer”, “neoplasm”, “tumor”. The inclusion criteria were: in vivo and in vitro studies on the use of limonene in cancer published in English, Portuguese and Spanish until December 2019. Review articles, meta-analyses, abstracts, conference papers, editorials/letters and case reports were excluded. Results: The search identified 3568 articles. Of which 126 were selected for full reading with 11 papers meeting the review criteria. Six more papers were added from the references of the initial 11 texts, giving a total of 17 papers. There was a high level of agreement on inclusion/exclusion (Kappa index > 80%). Risk of bias I the texts was shown to be high. Conclusion: The meta-analysis suggests that limonene acts mainly on tumor regression induced apoptosis, and is a promising natural product for use in the treatment of several types of cancer.

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