Relationship between cognition and age at onset of first-episode psychosis: comparative study between adolescents, young adults, and adults

2021 ◽  
Author(s):  
E. De la Serna ◽  
O. Puig ◽  
G. Mezquida ◽  
L. Moreno-Izco ◽  
J. Merchan-Naranjo ◽  
...  
Keyword(s):  
Young Adults ◽  
Comparative Study ◽  
Age At Onset ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

Insurance Status and Continuity for Young Adults With First-Episode Psychosis

2021 ◽  
pp. appi.ps.2019005
Author(s):  
Ezra Golberstein ◽  
Susan H. Busch ◽  
Kyaw Sint ◽  
Robert A. Rosenheck
Keyword(s):  
Young Adults ◽  
First Episode Psychosis ◽  
First Episode ◽  
Insurance Status ◽  
Episode Psychosis

scholarly journals A Brief Mindfulness-Based Family Psychoeducation Intervention for Chinese Young Adults With First Episode Psychosis: A Study Protocol

2019 ◽  
Vol 10 ◽  
Author(s):  
Herman Hay-Ming Lo ◽  
Wing-Chung Ho ◽  
Elsa Ngar-Sze Lau ◽  
Chun-Wai Lo ◽  
Winnie W. S. Mak ◽  
...  
Keyword(s):  
Young Adults ◽  
Study Protocol ◽  
First Episode Psychosis ◽  
First Episode ◽  
Family Psychoeducation ◽  
Episode Psychosis ◽  
Chinese Young Adults

scholarly journals Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors

2017 ◽  
Vol 47 (11) ◽  
pp. 1981-1989 ◽  
Author(s):  
A. Demjaha ◽  
J. M. Lappin ◽  
D. Stahl ◽  
M. X. Patel ◽  
J. H. MacCabe ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Age At Onset ◽  
Treatment Resistance ◽  
First Episode Psychosis ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Treatment Resistant ◽  
Illness Onset ◽  
Episode Psychosis

BackgroundWe examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypothesized that antipsychotic treatment resistance is: (a) present at illness onset; and (b) differentially associated with clinical and demographic factors.MethodThe study sample comprised 323 FEP patients who were studied at first contact and at 10-year follow-up. We collated clinical information on severity of symptoms, antipsychotic medication and treatment adherence during the follow-up period to determine the presence, course and predictors of treatment resistance.ResultsFrom the 23% of the patients, who were treatment resistant, 84% were treatment resistant from illness onset. Multivariable regression analysis revealed that diagnosis of schizophrenia, negative symptoms, younger age at onset, and longer duration of untreated psychosis predicted treatment resistance from illness onset.ConclusionsThe striking majority of treatment-resistant patients do not respond to first-line antipsychotic treatment even at time of FEP. Clinicians must be alert to this subgroup of patients and consider clozapine treatment as early as possible during the first presentation of psychosis.

scholarly journals Oral health experiences and needs among young adults after a first-episode psychosis : a phenomenological study

2018 ◽  
Vol 25 (8) ◽  
pp. 475-485 ◽  
Author(s):  
Sonja Kuipers ◽  
Stynke Castelein ◽  
Aaltsje Malda ◽  
Linda Kronenberg ◽  
Nynke Boonstra
Keyword(s):  
Young Adults ◽  
Oral Health ◽  
Phenomenological Study ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Health Experiences

scholarly journals A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance

2021 ◽  
Author(s):  
Kun Yang ◽  
Luisa Longo ◽  
Zui Narita ◽  
Nicola Cascella ◽  
Frederick C. Nucifora ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Biological Markers ◽  
Negative Symptoms ◽  
Age At Onset ◽  
First Episode Psychosis ◽  
First Episode ◽  
Imaging Data ◽  
Episode Psychosis ◽  
And Biological Markers ◽  
Brain Imaging Data

Treatment resistant (TR) psychosis is considered to be a significant cause of disability and functional impairment. Numerous efforts have been made to identify the clinical predictors of TR. However, the exploration of molecular and biological markers is still at an early stage. To understand the TR condition and identify potential molecular and biological markers, we analyzed demographic information, clinical data, structural brain imaging data, and molecular brain imaging data in 7 Tesla magnetic resonance spectroscopy, from a first episode psychosis cohort that includes 138 patients. Age, gender, race, smoking status, duration of illness, and antipsychotic dosages were controlled in the analyses. We found that TR patients had a younger age at onset, more hospitalizations, more severe negative symptoms, a significant reduction in the volumes of the hippocampus (HP) and superior frontal gyrus (SFG), and a significant reduction in glutathione (GSH) levels in the anterior cingulate cortex (ACC), when compared to non-TR patients. The combination of multiple markers provided a better classification between TR and non-TR patients compared to any individual marker. Our study shows that ACC GSH, HP and SFG volumes, and age at onset could potentially be trait biomarkers for TR diagnosis, while hospitalization and negative symptoms could be used to evaluate the progression of the disease. Multimodal cohorts are essential in obtaining a comprehensive understanding of brain disorders.

First-Person Accounts of Change Among Young Adults Enrolled in Coordinated Specialty Care for First-Episode Psychosis

2020 ◽  
Vol 71 (12) ◽  
pp. 1277-1284
Author(s):  
Tamara C. Daley ◽  
Nev Jones ◽  
Preethy George ◽  
Abram Rosenblatt
Keyword(s):  
Young Adults ◽  
First Episode Psychosis ◽  
Specialty Care ◽  
First Episode ◽  
First Person ◽  
Episode Psychosis

Severe Childhood Trauma Differentially Impacts Emotion Recognition in Males and Females with First-Episode Psychosis

2020 ◽  
Author(s):  
Danielle Penney ◽  
Marita Pruessner ◽  
Ashok K. Malla ◽  
Ridha Joober ◽  
Martin Lepage
Keyword(s):  
Emotion Recognition ◽  
Social Functioning ◽  
Childhood Trauma ◽  
Social Cognitive ◽  
Age At Onset ◽  
First Episode Psychosis ◽  
First Episode ◽  
Trauma Severity ◽  
Episode Psychosis ◽  
Males And Females

Background: Childhood trauma increases social functioning deficits, which in turn, negatively impact social inclusion in those experiencing first-episode psychosis (FEP). Associations between aberrant higher-order social cognitive processes such as emotion recognition (ER) and trauma severity may be one pathway by which trauma negatively impacts social functioning. Given sex differences identified in the experience of childhood trauma, it is pertinent to evaluate how trauma severity may differentially impact ER in males and females.Method: Eighty-three FEP participants (52 males, 31 females) and 69 nonclinical controls (49 males, 20 females) completed the CogState Research Battery. FEP participants completed the Childhood Trauma Questionnaire. A sex × group (FEP, controls) ANOVA examined ER differences and was followed by two-way ANCOVAs investigating the effects of sex and childhood trauma severity (none, low, moderate, severe) on ER and global cognition in FEP.Results: FEP participants had significantly lower ER scores than controls (p = .035). In FEP, a significant interaction emerged between sex and childhood trauma severity (F(3, 72) = 6.382, p = .001), selective to ER, while controlling for age at onset. Simple effects analyses revealed that females in the severe trauma category exhibited superior ER capacity relative to males. Conclusions: The differential impact of trauma severity on ER in males and females with FEP may be theoretically interpreted as the distinct way that hypervigilance affects the sexes. Early intervention services should refine social cognitive interventions in male and female trauma survivors to facilitate social functioning improvements.

Liminal Space of First-Episode Psychosis: Health Management and Its Effect on Social Participation

2021 ◽  
Vol 75 (6) ◽  
Author(s):  
Valerie Fox ◽  
Antoine L. Bailliard
Keyword(s):  
Young Adults ◽  
Social Participation ◽  
Mental Health Treatment ◽  
Health Management ◽  
First Episode Psychosis ◽  
First Episode ◽  
Treatment Burden ◽  
Liminal Space ◽  
Episode Psychosis ◽  
The Impact

Importance: Managing health requires extensive time and effort, especially in the early stages of a new illness. Although important, health management occupations contribute to treatment burden, disrupt engagement in other occupations, and galvanize the incorporation of the illness into identity. This is especially true for young adults after first-episode psychosis (FEP). Objective: To explore the impact of health management occupations on the social participation of young adults after FEP. Design: Qualitative study. Setting: Community with participants from primarily urban environments. Participants: Five adults between 18 and 30 yr old who experienced FEP within the previous 5 yr. Data collection occurred through semistructured interviews, participant observations, and discourse elicitation. Outcomes and Measures: Two participant observations per month for 6 mo with 4 study participants; six observations total for a 5th participant. Results: Health management dominated participants’ occupations immediately after FEP and hindered their social participation as they experienced a liminal space (i.e., transition space) in their life trajectory. Some participants were “stuck” in this space and deferred life goals to focus on illness management, whereas others used the liminal space as a space for growth and transformation. Conclusions and Relevance: Health management occupations are essential; however, overemphasizing health management can hinder social participation and quality of life. Occupational therapy practitioners can assist clients with moving through liminal spaces after diagnosis by supporting participation beyond mental health treatment environments, helping clients to imagine alternative life trajectories, and finding strategies to reduce overall treatment burden. What This Article Adds: The concept of liminality holds promise for understanding and supporting health management and social participation after FEP.

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