Prevalence and clinicopathological features of H3.3 G34-mutant high-grade gliomas: a retrospective study of 411 consecutive glioma cases in a single institution

2017 ◽  
Vol 34 (3) ◽  
pp. 103-112 ◽  
Author(s):  
Koji Yoshimoto ◽  
Ryusuke Hatae ◽  
Yuhei Sangatsuda ◽  
Satoshi O. Suzuki ◽  
Nobuhiro Hata ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Clinicopathological Features ◽  
High Grade ◽  
Single Institution ◽  
High Grade Gliomas

scholarly journals Loss of 5′-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 492 ◽  
Author(s):  
Weder Pereira de Menezes ◽  
Viviane Aline Oliveira Silva ◽  
Izabela Natália Faria Gomes ◽  
Marcela Nunes Rosa ◽  
Maria Luisa Corcoll Spina ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
In Silico ◽  
Glioma Cell ◽  
Clinicopathological Features ◽  
Migration And Invasion ◽  
High Grade ◽  
Methylthioadenosine Phosphorylase ◽  
Frequent Event ◽  
High Grade Gliomas

The 5’-methylthioadenosine phosphorylase (MTAP) gene is located in the chromosomal region 9p21. MTAP deletion is a frequent event in a wide variety of human cancers; however, its biological role in tumorigenesis remains unclear. The purpose of this study was to characterize the MTAP expression profile in a series of gliomas and to associate it with patients’ clinicopathological features. Moreover, we sought to evaluate, through glioma gene-edited cell lines, the biological impact of MTAP in gliomas. MTAP expression was evaluated in 507 glioma patients by immunohistochemistry (IHC), and the expression levels were associated with patients’ clinicopathological features. Furthermore, an in silico study was undertaken using genomic databases totalizing 350 samples. In glioma cell lines, MTAP was edited, and following MTAP overexpression and knockout (KO), a transcriptome analysis was performed by NanoString Pan-Cancer Pathways panel. Moreover, MTAP’s role in glioma cell proliferation, migration, and invasion was evaluated. Homozygous deletion of 9p21 locus was associated with a reduction of MTAP mRNA expression in the TCGA (The Cancer Genome Atlas) - glioblastoma dataset (p < 0.01). In addition, the loss of MTAP expression was markedly high in high-grade gliomas (46.6% of cases) determined by IHC and Western blotting (40% of evaluated cell lines). Reduced MTAP expression was associated with a better prognostic in the adult glioblastoma dataset (p < 0.001). Nine genes associated with five pathways were differentially expressed in MTAP-knockout (KO) cells, with six upregulated and three downregulated in MTAP. Analysis of cell proliferation, migration, and invasion did not show any significant differences between MTAP gene-edited and control cells. Our results integrating data from patients as well as in silico and in vitro models provide evidence towards the lack of strong biological importance of MTAP in gliomas. Despite the frequent loss of MTAP, it seems not to have a clinical impact in survival and does not act as a canonic tumor suppressor gene in gliomas.

Timing of re-irradiation in recurrent high-grade gliomas: a single institution study

2018 ◽  
Vol 138 (3) ◽  
pp. 571-579 ◽  
Author(s):  
A. Zemlin ◽  
B. Märtens ◽  
B. Wiese ◽  
R. Merten ◽  
D. Steinmann
Keyword(s):  
High Grade ◽  
Single Institution ◽  
High Grade Gliomas

scholarly journals ATIM-09. RETROSPECTIVE STUDY OF NIVOLUMAB FOR PATIENTS WITH RECURRENT HIGH GRADE GLIOMAS

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi27-vi28
Author(s):  
Ashley Pritchard ◽  
Frank Lieberman ◽  
Megan Mantica ◽  
Jan Drappatz
Keyword(s):  
Retrospective Study ◽  
High Grade ◽  
High Grade Gliomas

Impact of screening survey of gastric cancer on clinicopathological features and survival: Retrospective study at a single institution

Surgery ◽  
2000 ◽  
Vol 128 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Hirofumi Kubota ◽  
Tsukasa Kotoh ◽  
Reiko Masunaga ◽  
Dipok Kumar Dhar ◽  
Muneaki Shibakita ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Retrospective Study ◽  
Clinicopathological Features ◽  
Single Institution ◽  
Screening Survey

Dose-dense temozolomide for recurrent high-grade gliomas: a single-center retrospective study

2018 ◽  
Vol 35 (10) ◽  
Author(s):  
Catherine R. Garcia ◽  
Stacey A. Slone ◽  
Rachael M. Morgan ◽  
Lindsey Gruber ◽  
Sameera S. Kumar ◽  
...  
Keyword(s):  
Retrospective Study ◽  
High Grade ◽  
Single Center ◽  
High Grade Gliomas ◽  
Dose Dense

scholarly journals P13.19 * HYPOFRACTIONATED RADIOTHERAPY IN PATIENTS WITH HIGH GRADE GLIOMAS AND POOR PROGNOSTIC FACTORS: A RETROSPECTIVE STUDY

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii70-ii70
Author(s):  
F. Moretto ◽  
C. Mantovani ◽  
N. Giaj Levra ◽  
M. Levis ◽  
C. De Colle ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Retrospective Study ◽  
Hypofractionated Radiotherapy ◽  
High Grade ◽  
High Grade Gliomas

scholarly journals Diagnosis and management of multiple high-grade gliomas: a retrospective study

2019 ◽  
Author(s):  
Yang Gao ◽  
Hui Zheng ◽  
Liangdong Li ◽  
Changshuai Zhou ◽  
Xin Chen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Survival Time ◽  
Dna Methyltransferase ◽  
Therapeutic Strategies ◽  
Karnofsky Performance Scale ◽  
Subtotal Resection ◽  
Surgical Removal ◽  
High Grade ◽  
Survival Group ◽  
High Grade Gliomas

Abstract Background: Multiple high-grade gliomas (M-HGG) are uncommon lesions in the central nervous system. The management is controversial and the prognosis remains unfavorable. The aim of this study is to identify the characteristics of M-HGG and explore more appropriate therapeutic strategies for patients. Methods: A retrospective study was performed on 15 patients who were treated with M-HGG between August 2016 and March 2018 in our hospital. Clinical data including age, sex, Karnofsky Performance Scale (KPS) scores, number and location of lesions, surgical approach, pathology, adjuvant therapy (radio or chemotherapy) and prognosis were collected. Results: The most frequent position of tumors was temporal lobe, followed by frontal and occipital lobe. Patients who underwent surgical removal (gross total resection or subtotal resection) showed longer survival time than that in biopsy group (p < 0.05). The index of Ki-67 was higher (36.11 ± 1.8 vs 22.33 ± 2.1, p < 0.05) and the KPS score was lower (60.00 ± 2.7 vs 82.86 ± 2.9, p < 0.05) in death group than that in survival group. Two patients presented with different pathological grades: GBM (WHO IV), anaplastic astrocytoma (WHO III). Four patients presenting with methylation of genes of O-6-methylguanine DNA methyltransferase (MGMT) were still alive. No IDH1 mutation was detected in all cases. Eight patients died during follow-up, and the average survival period was 11.2 months. The survival time of living patients was more than 15.9 months. Conclusions: Surgical removal of dominant tumors of M-GBM is recommended, and stereotactic biopsy can achieve pathologic diagnosis if surgical removal is inaccessible. Comprehensive analysis of the clinical features and molecular pathology of multiple gliomas is helpful to find more effective diagnostic and therapeutic strategies.

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