scholarly journals Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study

Author(s):  
Silvia Benemei ◽  
Chiara Lupi ◽  
Francesco De Cesaris ◽  
Niccolò Lombardi ◽  
Alessandra Bettiol ◽  
...  
Cephalalgia ◽  
2016 ◽  
Vol 38 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Jasna J Zidverc-Trajkovic ◽  
Tatjana Pekmezovic ◽  
Zagorka Jovanovic ◽  
Aleksandra Pavlovic ◽  
Milija Mijajlovic ◽  
...  

Objective To evaluate long-term predictors of remission in patients with medication-overuse headache (MOH) by prospective cohort study. Background Knowledge regarding long-term predictors of MOH outcome is limited. Methods Two hundred and forty MOH patients recruited from 2000 to 2005 were included in a one-year follow-up study and then subsequently followed until 31 December 2013. The median follow-up was three years (interquartile range, three years). Predictive values of selected variables were assessed by the Cox proportional hazard regression model. Results At the end of follow-up, 102 (42.5%) patients were in remission. The most important predictors of remission were lower number of headache days per month before the one-year follow-up (HR-hazard ratio = 0.936, 95% confidence interval (CI) 0.884–0.990, p = 0.021) and efficient initial drug withdrawal (HR = 0.136, 95% CI 0.042–0.444, p = 0.001). Refractory MOH was observed in seven (2.9%) and MOH relapse in 131 patients (54.6%). Conclusions Outcome at the one-year follow-up is a reliable predictor of MOH long-term remission.


2020 ◽  
Vol 80 ◽  
pp. 152-155
Author(s):  
Florindo d'Onofrio ◽  
Arturo de Falco ◽  
Antonio Costanzo ◽  
Daniele Spitaleri ◽  
Gerardo Casucci ◽  
...  

2009 ◽  
Vol 136 (5) ◽  
pp. A-609
Author(s):  
Francis K.L. Chan ◽  
Jessica Ching ◽  
Bing Yee Suen ◽  
Justin Wu ◽  
Vincent W. Wong ◽  
...  

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e017359 ◽  
Author(s):  
Songwon Seo ◽  
Wan Young Lim ◽  
Dal Nim Lee ◽  
Jung Un Kim ◽  
Eun Shil Cha ◽  
...  

IntroductionThe cancer risk of radiation exposure in the moderate-to-high dose range has been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. Several epidemiological studies of Korean radiation workers have been conducted, but the data were analysed retrospectively in most cases. Moreover, groups with relatively high exposure, such as industrial radiographers, have been neglected. Therefore, we have launched a prospective cohort study of all Korean radiation workers to assess the health effects associated with occupational radiation exposure.Methods and analysisApproximately 42 000 Korean radiation workers registered with the Nuclear Safety and Security Commission from 2016 to 2017 are the initial target population of this study. Cohort participants are to be enrolled through a nationwide self-administered questionnaire survey between 24 May 2016 and 30 June 2017. As of 31 March 2017, 22 982 workers are enrolled in the study corresponding to a response rate of 75%. This enrolment will be continued at 5-year intervals to update information on existing study participants and recruit newly hired workers. Survey data will be linked with the national dose registry, the national cancer registry, the national vital statistics registry and national health insurance data via personal identification numbers. Age-specific and sex-specific standardised incidence and mortality ratios will be calculated for overall comparisons of cancer risk. For dose–response assessment, excess relative risk (per Gy) and excess absolute risk (per Gy) will be estimated with adjustments for birth year and potential confounders, such as lifestyle factors and socioeconomic status.Ethics and disseminationThis study has received ethical approval from the institutional review board of the Korea Institute of Radiological and Medical Sciences (IRB No. K-1603-002-034). All participants provided written informed consent prior to enrolment. The findings of the study will be disseminated through scientific peer-reviewed journals and be provided to the public, including radiation workers, via the study website (http://www.rhs.kr/) and onsite radiation safety education.


2017 ◽  
Vol 07 (08) ◽  
pp. 824-834
Author(s):  
Laura Emilia Muñoz Saá ◽  
María Dolores Martín Ríos ◽  
María Rosario Noguero Meseguer

2006 ◽  
Vol 32 (2) ◽  
pp. 458-470 ◽  
Author(s):  
Maartje M L de Win ◽  
Liesbeth Reneman ◽  
Gerry Jager ◽  
Erik-Jan P Vlieger ◽  
Sílvia D Olabarriaga ◽  
...  

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