AChRAb and MuSKAb double-seropositive myasthenia gravis: a distinct subtype?

Abstract Introduction This study investigated the characteristics of double-seropositive myasthenia gravis (DSP-MG) in southern China for disease subtype classification. Methods A case-control study was carried out in which the characteristics of DSP-MG patients (n = 17) were compared to those of muscle-specific tyrosine kinase antibody-positive (MuSK)-MG and acetylcholine receptor antibody-positive (AChR)-MG patients (n = 8 and 27, respectively). We also performed a literature review of DSP-MG patients. Results Compared to AChR-MG, DSP-MG had greater bulbar dysfunction (47.1% vs 18.6%, P = 0.04), higher incidence of myasthenia crisis (41.2% vs 14.8%, P = 0.04), more severe Myasthenia Gravis Foundation of America classification at maximum worsening, greater autoantibody abnormalities (70.6% vs 33.3%, P = 0.015), greater need for immunosuppressant treatment (58.8% vs 3.7%, P < 0.001), and worse prognosis with less remission (11.8% vs 55.6%, P = 0.001). There were no differences between DSP-MG and MuSK-MG patients. DSP-MG described in published reports was comparable to MuSK-MG. Discussion DSP-MG in southern China may be a subtype of MuSK-MG.

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Habitual physical activity reduces risk of ovarian cancer: A case–control study in southern China

Preventive Medicine ◽

10.1016/j.ypmed.2012.11.009 ◽

2013 ◽

Vol 57 ◽

pp. S31-S33 ◽

Cited By ~ 14

Author(s):

Andy H. Lee ◽

Dada Su ◽

Maria Pasalich ◽

Yut Lin Wong ◽

Colin W. Binns

Keyword(s):

Physical Activity ◽

Ovarian Cancer ◽

Case Control Study ◽

Southern China ◽

Case Control ◽

Habitual Physical Activity ◽

Control Study

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Maternal residential greenness and congenital heart defects in infants: A large case-control study in Southern China

Environment International ◽

10.1016/j.envint.2020.105859 ◽

2020 ◽

Vol 142 ◽

pp. 105859

Author(s):

Zhiqiang Nie ◽

Boyi Yang ◽

Yanqiu Ou ◽

Michael S. Bloom ◽

Fengzhen Han ◽

...

Keyword(s):

Congenital Heart Defects ◽

Congenital Heart ◽

Case Control Study ◽

Southern China ◽

Heart Defects ◽

Case Control ◽

Control Study ◽

Large Case

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Soy Consumption Reduces Risk of Ischemic Stroke: A Case-Control Study in Southern China

Neuroepidemiology ◽

10.1159/000222093 ◽

2009 ◽

Vol 33 (2) ◽

pp. 111-116 ◽

Cited By ~ 20

Author(s):

Wenbin Liang ◽

Andy H. Lee ◽

Colin W. Binns ◽

Rongsheng Huang ◽

Delong Hu ◽

...

Keyword(s):

Ischemic Stroke ◽

Case Control Study ◽

Southern China ◽

Case Control ◽

Control Study

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Speech characteristics in individuals with myasthenia gravis: a case control study

Logopedics Phoniatrics Vocology ◽

10.1080/14015439.2020.1834614 ◽

2020 ◽

pp. 1-8

Author(s):

Annelise Ayres ◽

Pablo Brea Winckler ◽

Laís Alves Jacinto-Scudeiro ◽

Rafaela Soares Rech ◽

Marina Martins Pereira Padovani ◽

...

Keyword(s):

Myasthenia Gravis ◽

Case Control Study ◽

Case Control ◽

Speech Characteristics ◽

Control Study

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The Polymorphism in ADORA3 Decreases Transcriptional Activity and Influences the Chronic Heart Failure Risk in the Chinese

BioMed Research International ◽

10.1155/2018/4969385 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9

Author(s):

Hai-Rong He ◽

Yuan-Jie Li ◽

Gong-Hao He ◽

Hua Qiang ◽

Ya-Jing Zhai ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Transcriptional Activity ◽

Case Control Study ◽

Southern China ◽

Case Control ◽

Luciferase Reporter ◽

Mrna Levels ◽

Chinese Han ◽

Control Study

Aim. To investigate the genetic contribution of adenosine A3 receptor (ADORA3) gene polymorphisms in the pathogenesis of chronic heart failure (CHF). Methods. Firstly, a case-control study was performed to investigate the association of ADORA3 polymorphisms with CHF risk. Three hundred northern Chinese Han CHF patients and 400 ethnicity-matched healthy controls were included. Four polymorphisms were genotyped. This case-control study was also replicated in 304 CHF patients and 402 controls from southern China. Finally, the functional variability of positive polymorphism was analyzed using luciferase reporter assay and real-time PCR. Results. Overall, the rs1544223 was significantly associated with CHF risk under the dominant model (P=0.046, OR = 1.662, 95% CI = 1.009–2.738). But it did not affect disease severity. These results were also consistent in replicated population. In addition, the transcriptional activity for promoter with the A allele was lower than that with the G allele (n=3, 4.501±0.308 versus 0.571±0.114, P<0.01) and ADORA3 mRNA levels were significantly higher in GG homozygotes than subjects carrying GA (n=6, 0.058±0.01 versus 0.143±0.068, P=0.004) or AA genotypes (n=6, 0.065±0.01 versus 0.143±0.068, P=0.008). Conclusions. Should the findings be validated by further studies with larger patient samples and in different ethnicities, they may provide novel insight into the pathogenesis of CHF.

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Subhaplogroup D4b1 enhances the risk of cervical cancer initiation: A case-control study in southern China

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.12879 ◽

2016 ◽

Vol 42 (3) ◽

pp. 325-330 ◽

Cited By ~ 3

Author(s):

Yuanyan Li ◽

Ximei Li ◽

Zhihui Wang ◽

Zejiao Feng ◽

Lijiao Li ◽

...

Keyword(s):

Cervical Cancer ◽

Case Control Study ◽

Southern China ◽

Case Control ◽

Cancer Initiation ◽

Control Study

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Habitual Physical Activity Reduces the Risk of Ischemic Stroke: A Case-Control Study in Southern China

Cerebrovascular Diseases ◽

10.1159/000235990 ◽

2009 ◽

Vol 28 (5) ◽

pp. 454-459 ◽

Cited By ~ 7

Author(s):

Wenbin Liang ◽

Andy H. Lee ◽

Colin W. Binns ◽

Qingkun Zhou ◽

Rongsheng Huang ◽

...

Keyword(s):

Physical Activity ◽

Ischemic Stroke ◽

Case Control Study ◽

Southern China ◽

Case Control ◽

Habitual Physical Activity ◽

Control Study

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A case-control study of autoimmune AEFIs following COVID-19 vaccination reported to VAERS

10.1101/2021.07.06.21260074 ◽

2021 ◽

Author(s):

Chris von Csefalvay

Keyword(s):

Myasthenia Gravis ◽

Case Control Study ◽

Case Reports ◽

Transverse Myelitis ◽

Case Control ◽

Vaccine Hesitancy ◽

Control Analysis ◽

Safety Signal ◽

Case Control Analysis ◽

Control Study

Autoimmune adverse effects following immunisation (AEFIs) are widely regarded as a chief concern driving vaccine hesitancy. This case-control study seeks to shed light on the true risk of autoimmune AEFIs associated with the COVID-19 vaccine through a case-control analysis of VAERS reports. Reports of autoimmune aetiology were matched with reports of non-autoimmune controls. Statistical analysis reveals that the safety profile of COVID-19 vaccines with regard to autoimmune AEFIs is highly favourable. In particular, neuroautoimmune AEFIs have statistically significant reporting odds ratios below unity (Guillain-Barre syndrome: 0.35, multiple sclerosis: 0.70, transverse myelitis: 0.79), indicating a reduced association of reports of these conditions with the COVID-19 vaccine versus other vaccines. Only three autoimmune aetiologies exceed a ROR of 2.0 and thus present a potential signal. Of these, myasthenia gravis (ROR = 3.90, p < 0.001, 95% CI: 2.63-5.80) may be the result of epidemiological confounding factors not sufficiently controlled by matching, as the population most likely to develop myasthenia gravis was strongly prioritised in the COVID-19 vaccine's initial rollout. Immune thrombocytopaenia (ROR = 26.83, p < 0.001, 95% CI: 16.93-42.54) is a clear safety signal, confirming a large number of case reports and studies that indicate a risk of immune thrombocytopaenic events following the COVID- 19 vaccine. The lone strong safety signal of immune thrombocytopaenia notwithstanding, this study attests to the safety of the COVID-19 vaccine where autoimmune conditions are concerned. Through quantifying the risk of autoimmune disorders associated with COVID-19 vaccination, this study contributes to a growing body of evidence supporting the safety of such vaccines.

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