Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

2016 ◽  
Vol 31 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Philipp M. Amann ◽  
Yvonne Marquardt ◽  
Timm Steiner ◽  
Frank Hölzle ◽  
Claudia Skazik-Voogt ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Laser Treatment ◽  
Three Dimensional ◽  
Glass Laser ◽  
Erbium Glass

scholarly journals Low versus High Fluence Parameters in the Treatment of Facial Laceration Scars with a 1,550 nm Fractional Erbium-Glass Laser

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Hyung-Sup Shim ◽  
Dai-Won Jun ◽  
Sang-Wha Kim ◽  
Sung-No Jung ◽  
Ho Kwon
Keyword(s):  
Laser Treatment ◽  
Global Assessment ◽  
Early Postoperative Period ◽  
Effective Energy ◽  
High Fluence ◽  
Effective Parameters ◽  
Fractional Laser ◽  
Glass Laser ◽  
Scar Management ◽  
Erbium Glass

Purpose. Early postoperative fractional laser treatment has been used to reduce scarring in many institutions, but the most effective energy parameters have not yet been established. This study sought to determine effective parameters in the treatment of facial laceration scars.Methods. From September 2012 to September 2013, 57 patients were enrolled according to the study. To compare the low and high fluence parameters of 1,550 nm fractional erbium-glass laser treatment, we virtually divided the scar of each individual patient in half, and each half was treated with a high and low fluence setting, respectively. A total of four treatment sessions were performed at one-month intervals and clinical photographs were taken at every visit.Results. Results were assessed using the Vancouver Scar Scale (VSS) and global assessment of the two portions of each individual scar. Final evaluation revealed that the portions treated with high fluence parameter showed greater difference compared to pretreatment VSS scores and global assessment values, indicating favorable cosmetic results.Conclusion. We compared the effects of high fluence and low fluence 1,550 nm fractional erbium-glass laser treatment for facial scarring in the early postoperative period and revealed that the high fluence parameter was more effective for scar management.

scholarly journals 712 Biological effects of non-ablative fractional erbium glass laser treatment and gene regulatory response in human 3D skin models

2016 ◽  
Vol 136 (5) ◽  
pp. S126
Author(s):  
P.M. Amann ◽  
Y. Marquardt ◽  
T. Steiner ◽  
F. Hölzle ◽  
C. Skazik-Voogt ◽  
...  
Keyword(s):  
Laser Treatment ◽  
Biological Effects ◽  
Glass Laser ◽  
Regulatory Response ◽  
Gene Regulatory ◽  
Erbium Glass ◽  
3D Skin

1540‐nm fractional erbium: Glass laser is a safe and effective modality for nonablative facial rejuvenation

2021 ◽  
Author(s):  
Efrat Solomon‐Cohen ◽  
Moshe Lapidoth ◽  
Daniel Mimouni ◽  
Lehavit Akerman ◽  
Dan Slodownik ◽  
...  
Keyword(s):  
Facial Rejuvenation ◽  
Glass Laser ◽  
Erbium Glass

scholarly journals Identification of the conserved long non-coding RNAs in myogenesis

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Anupam Bhattacharya ◽  
Simang Champramary ◽  
Tanya Tripathi ◽  
Debajit Thakur ◽  
Ilya Ioshikhes ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Muscle Development ◽  
Three Dimensional ◽  
C2c12 Cells ◽  
Mouse Muscle ◽  
Rna Molecules ◽  
Expression Of Genes ◽  
Novel Approach ◽  
Non Coding Rna ◽  
Topologically Associated Domains

Abstract Background Our understanding of genome regulation is ever-evolving with the continuous discovery of new modes of gene regulation, and transcriptomic studies of mammalian genomes have revealed the presence of a considerable population of non-coding RNA molecules among the transcripts expressed. One such non-coding RNA molecule is long non-coding RNA (lncRNA). However, the function of lncRNAs in gene regulation is not well understood; moreover, finding conserved lncRNA across species is a challenging task. Therefore, we propose a novel approach to identify conserved lncRNAs and functionally annotate these molecules. Results In this study, we exploited existing myogenic transcriptome data and identified conserved lncRNAs in mice and humans. We identified the lncRNAs expressing differentially between the early and later stages of muscle development. Differential expression of these lncRNAs was confirmed experimentally in cultured mouse muscle C2C12 cells. We utilized the three-dimensional architecture of the genome and identified topologically associated domains for these lncRNAs. Additionally, we correlated the expression of genes in domains for functional annotation of these trans-lncRNAs in myogenesis. Using this approach, we identified conserved lncRNAs in myogenesis and functionally annotated them. Conclusions With this novel approach, we identified the conserved lncRNAs in myogenesis in humans and mice and functionally annotated them. The method identified a large number of lncRNAs are involved in myogenesis. Further studies are required to investigate the reason for the conservation of the lncRNAs in human and mouse while their sequences are dissimilar. Our approach can be used to identify novel lncRNAs conserved in different species and functionally annotated them.

scholarly journals Scientific validation of three-dimensional stereophotogrammetry compared to the IGAIS clinical scale for assessing wrinkles and scars after laser treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Barbara Helena Barcaro Machado ◽  
Ivy Dantas De Melo E. Silva ◽  
Walter Marou Pautrat ◽  
James Frame ◽  
Mohammad Najlah
Keyword(s):  
Laser Treatment ◽  
Three Dimensional ◽  
Skin Surface ◽  
Clinical Scale ◽  
3D Images ◽  
Laser Resurfacing ◽  
Before And After ◽  
Measuring Outcomes ◽  
Skin Scar ◽  
Scientific Validation

AbstractMeasuring outcomes from treatments to the skin is either reliant upon patient’s subjective feedback or scale-based peer assessments. Three-Dimensional stereophotogrammetry intend to accurately quantify skin microtopography before and after treatments. The objective of this study is comparing the accuracy of stereophotogrammetry with a scale-based peer evaluation in assessing topographical changes to skin surface following laser treatment. A 3D stereophotogrammetry system photographed skin surface of 48 patients with facial wrinkles or scars before and three months after laser resurfacing, followed immediately by topical application of vitamin C. The software measured changes in skin roughness, wrinkle depth and scar volume. Images were presented to three observers, each independently scoring cutaneous improvement according to Investigator Global Aesthetic Improvement Scale (IGAIS). As for the results, a trend reflecting skin/scar improvement was reported by 3D SPM measurements and raters. The percentage of topographical change given by the raters matched 3D SPM findings. Agreement was highest when observers analysed 3D images. However, observers overestimated skin improvement in a nontreatment control whilst 3D SPM was precise in detecting absence of intervention. This study confirmed a direct correlation between the IGAIS clinical scale and 3D SPM and confirmed the efficacy and accuracy of the latter when assessing cutaneous microtopography alterations as a response to laser treatment.

Passive Q-switching of erbium glass laser by magnesium aluminosilicate sitall with cobalt ions

2007 ◽  
Vol 74 (1) ◽  
pp. 140-146 ◽  
Author(s):  
Yu. V. Volk ◽  
A. M. Malyarevich ◽  
K. V. Yumashev ◽  
O. S. Dymshits ◽  
A. V. Shashkin ◽  
...  
Keyword(s):  
Glass Laser ◽  
Cobalt Ions ◽  
Q Switching ◽  
Erbium Glass

Efficacy of erbium glass laser in the treatment of Old World cutaneous leishmaniasis: A case series

2018 ◽  
Vol 60 (1) ◽  
pp. e29-e32 ◽  
Author(s):  
Vahid Mashayekhi Goyonlo ◽  
Mahboubeh Karrabi ◽  
Bita Kiafar
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Case Series ◽  
Glass Laser ◽  
Old World ◽  
Erbium Glass

Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm

2013 ◽  
Author(s):  
Michael J. Myers ◽  
Jeffrey A. Myers ◽  
Franziska Roth ◽  
Baoping Guo ◽  
Christopher R. Hardy ◽  
...  
Keyword(s):  
Glass Laser ◽  
Fungus Infection ◽  
Erbium Glass

scholarly journals Chemical Decorations of “MARs” Residents in Orchestrating Eukaryotic Gene Regulation

2020 ◽  
Vol 8 ◽  
Author(s):  
Tanaya Roychowdhury ◽  
Samit Chattopadhyay
Keyword(s):  
Gene Regulation ◽  
Conformational Changes ◽  
Protein Interactions ◽  
Protein Function ◽  
Functional Outcomes ◽  
Three Dimensional ◽  
Limited Information ◽  
Post Translational Modification ◽  
Cellular Functions ◽  
3D Matrix

Genome organization plays a crucial role in gene regulation, orchestrating multiple cellular functions. A meshwork of proteins constituting a three-dimensional (3D) matrix helps in maintaining the genomic architecture. Sequences of DNA that are involved in tethering the chromatin to the matrix are called scaffold/matrix attachment regions (S/MARs), and the proteins that bind to these sequences and mediate tethering are termed S/MAR-binding proteins (S/MARBPs). The regulation of S/MARBPs is important for cellular functions and is altered under different conditions. Limited information is available presently to understand the structure–function relationship conclusively. Although all S/MARBPs bind to DNA, their context- and tissue-specific regulatory roles cannot be justified solely based on the available information on their structures. Conformational changes in a protein lead to changes in protein–protein interactions (PPIs) that essentially would regulate functional outcomes. A well-studied form of protein regulation is post-translational modification (PTM). It involves disulfide bond formation, cleavage of precursor proteins, and addition or removal of low-molecular-weight groups, leading to modifications like phosphorylation, methylation, SUMOylation, acetylation, PARylation, and ubiquitination. These chemical modifications lead to varied functional outcomes by mechanisms like modifying DNA–protein interactions and PPIs, altering protein function, stability, and crosstalk with other PTMs regulating subcellular localizations. S/MARBPs are reported to be regulated by PTMs, thereby contributing to gene regulation. In this review, we discuss the current understanding, scope, disease implications, and future perspectives of the diverse PTMs regulating functions of S/MARBPs.

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