Black Fungus: A Lethal Communal Issue After Winning the Life Battle Against COVID-19

The authors aimed to give a quick reference guide for humanity about the new threat even after the COVID-19 health battle i.e., the Black fungus also baptized as Mucormycosis infection. After recovering from COVID-19, patients with diabetes mellitus and patients who have undergone steroidal treatment are more prone to black fungus infection. This review gives quick information about various types of Mucormycosis infections, risk factors, symptoms, treatment, and prevention of black fungus. The things that can be and cannot be done to eradicate the black fungus. Any sign of black nasal mucosa/sputum, fever, headache, hazy/blurred/double vision with eye pain, loss of one side sensation on face and loss in the sensation while chewing, etc., then it should not be neglected and immediately intimated to the health professionals and get treated. If black fungus is unidentified early stages and untreated in time, the patients may lose their facial/neck parts as a part of cleaning surgery. The study concludes that by maintaining hygienic conditions, health checkups, and doctors’ advice one can fight and eradicate the black fungus.

Mucormycosis and its association with coronavirus disease – 19

The pandemic coronavirus disease (COVID – 19) has been turning out to be an agonizing catastrophe among the human population all over the world. Among a perfect storm of the 2nd wave of COVID – 19, there is widespread and significant challenge due to the prevalence of the “MUCORMYCOSIS - the Black fungus infection.” It is a deadly but rare opportunistic fungal infection that mainly affects the immunocompromised people. It has been associated with COVID -19 as a Post – COVID manifestation among the recovered patients. The article provides information about Mucormycosis, its etiology, pathogenesis, predisposing factors, clinical manifestations, diagnosis, and management.

Ayurveda approaches to COVID-19 in 2 wave: Lessons learned from practice

Ayurveda is a live traditional system of medicine with an unbreakable practice since 3000 years. Its principles and its approaches including oral administration of preventive drugs, herbs, formulae, decoction, indoor herbal medicine for fumigation, etc. were recommended for effective prevention and treatment whenever the emergent of new diseases. This paper highlights the patho-physiology of Corona as per Ayurveda, Clinical staging, preventive and curative approaches as learned time to time. and Anu taila nasya have excellent practice evidences for prevention of Covid-19 in 1 wave of corona. Sajeevani app developed by AYUSH to study the AYUSH practices. AYUSH -64 is an evidence-based treatment to cure mild to moderate COVID infection developed by Central Council for Research in Ayurveda Sciences. The second wave of COVID-19 is more tragedy than 1 wave and its impact on health care systems of our nation is devastating and unprecedented. National campaign for AYUSH-64 started and it is recommended in National Clinical Management Protocol based on Ayurveda and Yoga which is vetted by National Task Force on COVID management for COVID-19 Patients in Home Isolation. All Institute of Ayurveda released list of medicines for management of various symptoms of Covid. General public have more trusted upon Ayurveda practitioners as controversies of addition and deletion of steroid and antiviral in modern treatment protocol. The horror of Black (Mucormycosis) and white (Candiditis) fungus infection due to irrational use of immunosuppressive drugs confused the general people. More numbers of Covid patients received AYUSH-64 in 2 wave. Ayurveda Practice requires sound knowledge of Yukti Pramana(Logic and self judgement) by discerning clinical for better outcome irrespective of evidences and guidelines. We all are learning the pathogenesis of different mutants of Covid. Ayurveda approaches reduced the complication and progression of disease. This review will provide basic understanding Ayurveda for covid care.

Metanephric Adenoma Associated with Unusual Urinary Candidiasis: A Challenging Morbidity from Postoperative Anastomotic Leak

Metanephric adenoma (MA) of the kidney is a rare benign neoplasm, which is mostly incidental-discovered during imaging studies for other clinical problems. However, this tumor may overlap in morphology with the papillary renal cell carcinoma and there are descriptions of metastatic disease. To date, fewer than 200 cases of MA have been reported worldwide and usually have a good prognosis. In the current report, a case of MA in a middle-aged lady is presented, which developed postoperative morbidity resulting from prolonged perinephric leakage secondary to urinary and perinephric fungus infection as a part of systemic candidiasis. The clinical, morphological and immunohistochemical features are presented together with a review of the current literature.

The resurgence of black fungus in the context of Covid -19 second wave epidemic in India

There is a sudden surge of the cases of the black fungus infection ((mucormycosis / Zygomycosis), at a time when India is reeling under a catastrophe created by the second wave of Covid -19. it is like a 'medical tsunami, ' that ravaged the health care system and the administration alike, both being caught unaware. In the beginning, there is an acute shortage of hospital beds earmarked for this infection, and the lifesaving drug, the liposomal Amphotersin B, coupled with the appalling morbidity, mortality, not to speak of the financial burden and the resource crunch, that is inflicted by it.This article briefly reviews the black fungus infection in India, in the pre and post Covid -19 eras. The risk factors for the black fungus, both Covid associated (CAR) as well as non-Covid -19 associated, are discussed. The host as well as pathogen related factors, in the pathogenesis of the black fungus infection, are explored. An alternative explanation to diabetic ketoacidosis, (DKA) in providing the acidic pH required by the fungus, is hypothesized, as the occurrence of the infection, in the absence of DKA, remained inexplicable. It may be noted that the acidic pH is responsible for making available, the free iron from the host ‘s serum, that is needed for the sustenance, grouth and multiplication of the fungus, as well as causing phagocytic dysfunction in the host. The different clinical presentations of mucormycosis, their salient clinical features and the management are outlined in the present article.

Mucormycosis and COVID-19 an epidemic in a pandemic?

Mucormycosis and aspergillosis are rare, invasive and life-threatening infections. The causative agents being namely: Aspergillus fumigatus and Rhizopus arrhizus. The case fatality rates being over 50% respectively. Invasive Aspergillosis and Mucormycosis have been established and recognized as a complication of the SARS-CoV-2 infection. These cases have been intimately linked and related to prior corticosteroid therapy. With the new B.1.617.2 and B.1.617.2.1 or AY.1 strain of the coronavirus running rampant throughout India causing unprecedented death tolls, a new crisis is evolving. Invasive “black fungus” (Mucormycosis) is creating an epidemic within a global pandemic. The unique socio-economic, genetic and health status of India’s population culminates into a melting pot which sustains the viable triad for the “black fungus” infection to gain a stronghold. Diabetes mellitus, immunosuppression and the current COVID-19 global pandemic with its massive surges in the country have produced the “perfect storm.” Eye surgeons from around India are registering a surge in invasive Mucormycosis cases with a rise in orbital compartment syndrome often calling for radical procedures such as enucleation surgeries. The “black fungus” pandemic and invasive Mucormycosis occurring in COVID-19 patients in India is a depiction of the sinister secondary infections and complications intimately linked with the virus. It is therefore of the upmost importance that countries surrounding India in particular Nepal and other Asiatic nations take great cognizance of this indolent “black fungus killer” and ensure new screening and testing protocols are put into place.