scholarly journals Long-term outcomes and prognostic factors with non-curative endoscopic submucosal dissection for gastric cancer in elderly patients aged ≥ 75 years

2018 ◽  
Vol 22 (4) ◽  
pp. 838-844 ◽  
Author(s):  
Yosuke Toya ◽  
Masaki Endo ◽  
Shotaro Nakamura ◽  
Risaburo Akasaka ◽  
Shunichi Yanai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Elderly Patients ◽  
Endoscopic Submucosal Dissection ◽  
Long Term Outcomes ◽  
Submucosal Dissection

scholarly journals Long-Term Outcomes and Prognostic Factors of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients Aged ≥75 Years

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3222
Author(s):  
Jin Won Chang ◽  
Da Hyun Jung ◽  
Jun Chul Park ◽  
Sung Kwan Shin ◽  
Sang Kil Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Prognostic Factors ◽  
Early Gastric Cancer ◽  
Elderly Patients ◽  
Endoscopic Submucosal Dissection ◽  
Clinical Outcomes ◽  
Risk Group ◽  
Submucosal Dissection

Background and Aims: The number of elderly patients with early gastric cancer (EGC) who meet the indications for endoscopic submucosal dissection (ESD) is increasing. We aimed to evaluate the clinical outcomes and prognostic factors of overall survival (OS) in elderly patients undergoing ESD for EGC. Methods: Between January 2006 and December 2018, 439 patients aged ≥75 years who underwent ESD for EGC were analyzed. The clinical outcomes and prognosis were evaluated, and independent risk factors for OS were identified. Results: The mean patient (302 men, 137 women) age was 78.3 (range 75–92) years. En bloc, R0, and curative resections were achieved in 96.8%, 90.7%, and 75.6%, respectively, without severe adverse events. During the follow-up (median 54.2 (range 4.0–159.6) months), 86 patients died (three of gastric cancer). The 3-, 5-, and 10-year OS was 91.2%, 83.5%, and 54.5%, respectively, and the 3-, 5-, and 10-year cancer related survival rate were 99.7%, 99.1% and 97.5%, respectively. In multivariate analysis, smoking, history of cancer of other organs, NLR > 1.6, Charlson comorbidity index ≥ 3, and presence of lymphovascular invasion (hazard ratio = 3.96, 1.78, 1.83, 1.83, and 2.63, respectively, all p < 0.05) were independent five risk factors for poor OS. The high-risk group (≥3 risk factors) showed a significantly lower OS than the low-risk group (<2 risk factors) (p < 0.001). Conclusions: The five factors could be useful in predicting the long-term prognosis of elderly ESD patients or deciding the therapeutic approaches in case of non-curative resection.

scholarly journals Short- and long-term outcomes of endoscopic submucosal dissection for early gastric cancer in elderly patients aged 75 years and older

2016 ◽  
Vol 20 (3) ◽  
pp. 489-495 ◽  
Author(s):  
Tetsuya Sumiyoshi ◽  
Hitoshi Kondo ◽  
Ryoji Fujii ◽  
Takeyoshi Minagawa ◽  
Shinya Fujie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Elderly Patients ◽  
Endoscopic Submucosal Dissection ◽  
Long Term Outcomes ◽  
Submucosal Dissection ◽  
Short And Long Term

scholarly journals Impact of Comorbidities, Sarcopenia, and Nutritional Status on the Long-Term Outcomes after Endoscopic Submucosal Dissection for Early Gastric Cancer in Elderly Patients Aged ≥ 80 Years

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3598
Author(s):  
Ga Hee Kim ◽  
Kee Don Choi ◽  
Yousun Ko ◽  
Taeyong Park ◽  
Kyung Won Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Early Gastric Cancer ◽  
Nutritional Status ◽  
Elderly Patients ◽  
Endoscopic Submucosal Dissection ◽  
Term Survival ◽  
Factors Associated ◽  
Submucosal Dissection

Background/Aim: We investigated the oncologic outcomes in elderly patients who underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) by focusing on the impact of comorbidities, sarcopenia, and nutritional status. Methods: Between 2005 and 2016, 280 patients aged ≥ 80 years with 289 EGCs underwent ESD at a tertiary care center. The short- and long-term survival outcomes were assessed. Cox regression analysis was used to identify factors associated with survival, including clinicopathologic factors and abdominal muscle area measured by computed tomography. Results: The rates of en bloc, R0, and, curative resection were 99.3%, 90.0%, and 69.2%, respectively. The rates of post-ESD bleeding and perforation rates were 2.1% and 3.1%, respectively, and no cases showed significant life-threatening adverse events. Over a median follow-up period of 70.5 months, the 3- and 5-year overall survival (OS) rates were 89.5% and 77.1%, respectively; of the114 patients who died, only four (3.5%) were due to gastric cancer. A total of 173 (61.8%) had sarcopenia, and they had lower rates of 3-year (88.4% vs. 91.4%) and 5-year (73.1% vs. 84.0%; p = 0.046) OS than did those without sarcopenia. In multivariable analyses, prognostic nutritional index (hazard ratio [HR], 0.93; 95% confidence interval [CI]: 0.90–0.98; p = 0.002) and Charlson comorbidity index (HR 1.19; 95% CI: 1.03–1.37; p = 0.018) were significant factors associated with overall survival. Conclusions: ESD was a feasible and safe therapeutic method to use in elderly patients, whose long-term survival was significantly associated with nutritional status and comorbidities. These results suggest the need for a possible extension of the curative criteria for ESD in elderly patients with EGC.

Long‐term outcomes of endoscopic submucosal dissection versus surgery in early gastric cancer

2019 ◽  
Vol 31 (4) ◽  
pp. 418-424 ◽  
Author(s):  
Mohamed M. Abdelfatah ◽  
Mohamed Barakat ◽  
Dina Ahmad ◽  
Mariam Ibrahim ◽  
Yahia Ahmed ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Long Term Outcomes ◽  
Submucosal Dissection

Short- and long-term outcomes of endoscopic submucosal dissection for undifferentiated early gastric cancer

Endoscopy ◽  
2013 ◽  
Vol 45 (09) ◽  
pp. 703-707 ◽  
Author(s):  
Seiichiro Abe ◽  
Ichiro Oda ◽  
Haruhisa Suzuki ◽  
Satoru Nonaka ◽  
Shigetaka Yoshinaga ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Long Term Outcomes ◽  
Submucosal Dissection ◽  
Undifferentiated Early Gastric Cancer ◽  
Short And Long Term

211 Long Term Outcomes and Prognosis of Endoscopic Submucosal Dissection for Early Gastric Cancer: a Multi-Institutional Joint Study

2015 ◽  
Vol 81 (5) ◽  
pp. AB124-AB125
Author(s):  
Satoshi Tanabe ◽  
Kenji Ishido ◽  
Takashi Kosaka ◽  
Haruhisa Suzuki ◽  
Junko Fujisaki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Long Term Outcomes ◽  
Submucosal Dissection ◽  
Joint Study

Prognostic factors for short-term and long-term outcomes of gastric cancer surgery for elderly patients: 10 years of experience at a single tertiary care center

2018 ◽  
Vol 70 (2) ◽  
pp. 265-271 ◽  
Author(s):  
Stefano de Pascale ◽  
Daniele Belotti ◽  
Andrea Celotti ◽  
Eleonora Maddalena Minerva ◽  
Vittorio Quagliuolo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Elderly Patients ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Long Term Outcomes ◽  
Short Term ◽  
Gastric Cancer Surgery
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