Antimicrobial activities of tosufloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella branhamella catarrhalis isolated from otolaryngological infectious diseases

2005 ◽  
Vol 11 (5) ◽  
pp. 253-255 ◽  
Author(s):  
Kenji Suzuki ◽  
Toshiyuki Fujisawa ◽  
Mayuki Nakashima ◽  
Risa Hamasaki
Keyword(s):  
Streptococcus Pneumoniae ◽  
Infectious Diseases ◽  
Haemophilus Influenzae ◽  
Antimicrobial Activities ◽  
Branhamella Catarrhalis

scholarly journals Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates ofHaemophilus influenzae and Streptococcus pneumoniae

1999 ◽  
Vol 43 (5) ◽  
pp. 1291-1293 ◽  
Author(s):  
Kimberly L. Bergman ◽  
Keith M. Olsen ◽  
Tom E. Peddicord ◽  
Paul D. Fey ◽  
Mark E. Rupp
Keyword(s):  
Antimicrobial Activity ◽  
Streptococcus Pneumoniae ◽  
Epithelial Cell ◽  
Haemophilus Influenzae ◽  
Antimicrobial Activities ◽  
Postantibiotic Effect ◽  
Drug Concentrations ◽  
Ofhaemophilus Influenzae ◽  
Cell Lining ◽  
Epithelial Cell Lining

ABSTRACT The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin againstStreptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin againstHaemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

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