Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates ofHaemophilus influenzae and Streptococcus pneumoniae

ABSTRACT The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin againstStreptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin againstHaemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

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Antimicrobial activity of LB10827, a new orally administered cephalosporin, tested against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae

Clinical Microbiology and Infection ◽

10.1046/j.1469-0691.2003.00645.x ◽

2003 ◽

Vol 9 (8) ◽

pp. 893-896 ◽

Cited By ~ 1

Author(s):

L.M. Deshpande ◽

M.L. Beach ◽

A. H Mutnick ◽

R.N. Jones

Keyword(s):

Antimicrobial Activity ◽

Streptococcus Pneumoniae ◽

Haemophilus Influenzae ◽

Moraxella Catarrhalis

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A7.16 In Vitro antimicrobial activity of cefditoren against Streptococcus pneumoniae and Haemophilus influenzae clinical isolates

International Journal of Antimicrobial Agents ◽

10.1016/s0924-8579(05)80234-1 ◽

2005 ◽

Vol 26 ◽

pp. S83

Keyword(s):

Antimicrobial Activity ◽

Streptococcus Pneumoniae ◽

Haemophilus Influenzae ◽

Clinical Isolates ◽

In Vitro Antimicrobial Activity

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Postantibiotic Effects of ABT-773 and Amoxicillin-Clavulanate against Streptococcus pneumoniae andHaemophilus influenzae

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.45.12.3613-3615.2001 ◽

2001 ◽

Vol 45 (12) ◽

pp. 3613-3615 ◽

Cited By ~ 5

Author(s):

Melinda M. Neuhauser ◽

Jennifer L. Prause ◽

Larry H. Danziger ◽

Susan L. Pendland

Keyword(s):

Streptococcus Pneumoniae ◽

Haemophilus Influenzae ◽

Clinical Isolates ◽

Postantibiotic Effect ◽

Amoxicillin Clavulanate

ABSTRACT This study determined the postantibiotic effect (PAE) of ABT-773 versus that of amoxicillin-clavulanate against clinical isolates ofStreptococcus pneumoniae and Haemophilus influenzae. The PAEs of ABT-773 and amoxicillin-clavulanate ranged from 2.3 to 6.0 h and 0 to 2.2 h against S. pneumoniae and from 2.7 to 9.1 h and 0 to 0.8 h againstH. influenzae, respectively.

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The roles of epithelial cell contact, respiratory bacterial interactions and phosphorylcholine in promoting biofilm formation by Streptococcus pneumoniae and nontypeable Haemophilus influenzae

Microbes and Infection ◽

10.1016/j.micinf.2014.06.008 ◽

2014 ◽

Vol 16 (8) ◽

pp. 640-647 ◽

Cited By ~ 5

Author(s):

Ajay Krishnamurthy ◽

Jennelle Kyd

Keyword(s):

Streptococcus Pneumoniae ◽

Epithelial Cell ◽

Haemophilus Influenzae ◽

Biofilm Formation ◽

Cell Contact ◽

Nontypeable Haemophilus Influenzae ◽

Bacterial Interactions

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Postantibiotic effect of trovafloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis in cerebrospinal fluid and broth culture media

Diagnostic Microbiology and Infectious Disease ◽

10.1016/s0732-8893(99)00148-0 ◽

2000 ◽

Vol 36 (4) ◽

pp. 241-247 ◽

Cited By ~ 3

Author(s):

Pamela R. Tessier ◽

Charles H. Nightingale ◽

David P. Nicolau

Keyword(s):

Cerebrospinal Fluid ◽

Streptococcus Pneumoniae ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Culture Media ◽

Broth Culture ◽

Postantibiotic Effect

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Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae

BMC Infectious Diseases ◽

10.1186/1471-2334-4-12 ◽

2004 ◽

Vol 4 (1) ◽

Cited By ~ 90

Author(s):

Haa-Yung Lee ◽

Ali Andalibi ◽

Paul Webster ◽

Sung-Kyun Moon ◽

Karen Teufert ◽

...

Keyword(s):

Antimicrobial Activity ◽

Streptococcus Pneumoniae ◽

Haemophilus Influenzae ◽

Moraxella Catarrhalis ◽

Innate Immune ◽

Nontypeable Haemophilus Influenzae

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Antimicrobial activities of tosufloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella branhamella catarrhalis isolated from otolaryngological infectious diseases

Journal of Infection and Chemotherapy ◽

10.1007/s10156-005-0397-8 ◽

2005 ◽

Vol 11 (5) ◽

pp. 253-255 ◽

Cited By ~ 3

Author(s):

Kenji Suzuki ◽

Toshiyuki Fujisawa ◽

Mayuki Nakashima ◽

Risa Hamasaki

Keyword(s):

Streptococcus Pneumoniae ◽

Infectious Diseases ◽

Haemophilus Influenzae ◽

Antimicrobial Activities ◽

Branhamella Catarrhalis

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Antimicrobial activity against Streptococcus pneumoniae and Haemophilus influenzae collected globally between 2004 and 2008 as part of the Tigecycline Evaluation and Surveillance Trial

Diagnostic Microbiology and Infectious Disease ◽

10.1016/j.diagmicrobio.2009.12.009 ◽

2010 ◽

Vol 67 (1) ◽

pp. 78-86 ◽

Cited By ~ 19

Author(s):

Ali Darabi ◽

Didier Hocquet ◽

Michael J. Dowzicky

Keyword(s):

Antimicrobial Activity ◽

Streptococcus Pneumoniae ◽

Haemophilus Influenzae

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In Vitro Antimicrobial Activities of Organic Acids and Their Derivatives on Several Species of Gram-Negative and Gram-Positive Bacteria

Molecules ◽

10.3390/molecules24203770 ◽

2019 ◽

Vol 24 (20) ◽

pp. 3770 ◽

Cited By ~ 10

Author(s):

Lauren Kovanda ◽

Wen Zhang ◽

Xiaohong Wei ◽

Jia Luo ◽

Xixi Wu ◽

...

Keyword(s):

Escherichia Coli ◽

Antimicrobial Activity ◽

Streptococcus Pneumoniae ◽

Organic Acids ◽

Enterococcus Faecalis ◽

Sodium Formate ◽

Antimicrobial Activities ◽

Bacterial Strains ◽

Gram Negative

The objective of this study was to determine the in vitro antimicrobial activity of several organic acids and their derivatives against Gram-positive (G+) and Gram-negative (G−) bacteria. Butyric acid, valeric acid, monopropionin, monobutyrin, monovalerin, monolaurin, sodium formate, and ProPhorce—a mixture of sodium formate and formic acid (40:60 w/v)—were tested at 8 to 16 concentrations from 10 to 50,000 mg/L. The tested bacteria included G− bacteria (Escherichia coli, Salmonella enterica Typhimurium, and Campylobacter jejuni) and G+ bacteria (Enterococcus faecalis, Clostridium perfringens, Streptococcus pneumoniae, and Streptococcus suis). Antimicrobial activity was expressed as minimum inhibitory concentration (MIC) of tested compounds that prevented growth of tested bacteria in treated culture broth. The MICs of butyric acid, valeric acid, and ProPhorce varied among bacterial strains with the lowest MIC of 500–1000 mg/L on two strains of Campylobacter. Sodium formate at highest tested concentrations (20,000 mg/L) did not inhibit the growth of Escherichia coli, Salmonella Typhimurium, and Enterococcus faecalis, but sodium formate inhibited the growth of other tested bacteria with MIC values from 2000 to 18,800 mg/L. The MIC values of monovalerin, monolaurin, and monobutyrin ranged from 2500 to 15,000 mg/L in the majority of bacterial strains. Monopropionin did not inhibit the growth of all tested bacteria, with the exception that the MIC of monopropionin was 11,300 mg/L on Clostridia perfringens. Monolaurin strongly inhibited G+ bacteria, with the MIC value of 10 mg/L against Streptococcus pneumoniae. The MIC tests indicated that organic acids and their derivatives exhibit promising antimicrobial effects in vitro against G− and G+ bacteria that are resistant to antimicrobial drugs. The acid forms had stronger in vitro antimicrobial activities than ester forms, except that the medium chain fatty acid ester monolaurin exhibited strong inhibitory effects on G+ bacteria.

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