Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Abstract Objectives Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization. Materials and methods Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement. Results Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65–74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided. Discussion The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

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Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Magnetic Resonance Materials in Physics Biology and Medicine ◽

10.1007/s10334-020-00828-6 ◽

2020 ◽

Vol 33 (1) ◽

pp. 197-198 ◽

Cited By ~ 1

Author(s):

Alexandra Ljimani ◽

Anna Caroli ◽

Christoffer Laustsen ◽

Susan Francis ◽

Iosif Alexandru Mendichovszky ◽

...

Keyword(s):

Clinical Translation ◽

Diffusion Weighted Mri ◽

Diffusion Weighted ◽

Renal Diffusion ◽

Technical Recommendations

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Faculty Opinions recommendation of Developing a clinical pathway for the identification and management of anxiety and depression in adult cancer patients: an online Delphi consensus process.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725447352.793539487 ◽

2017 ◽

Author(s):

David Spiegel

Keyword(s):

Cancer Patients ◽

Clinical Pathway ◽

Anxiety And Depression ◽

Delphi Consensus ◽

Consensus Process

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Vaccinations in patients with multiple sclerosis: A Delphi consensus statement

Multiple Sclerosis Journal ◽

10.1177/1352458520952310 ◽

2020 ◽

pp. 135245852095231 ◽

Cited By ~ 1

Author(s):

Agostino Riva ◽

Valeria Barcella ◽

Simone V Benatti ◽

Marco Capobianco ◽

Ruggero Capra ◽

...

Keyword(s):

Multiple Sclerosis ◽

Seasonal Influenza ◽

Careful Consideration ◽

Delphi Consensus ◽

Consensus Process ◽

Disease Modifying Drugs ◽

Risks And Benefits ◽

Modified Delphi ◽

Increased Risk ◽

Evidence Based Decision Making

Background: Patients with multiple sclerosis (MS) are at increased risk of infection. Vaccination can mitigate these risks but only if safe and effective in MS patients, including those taking disease-modifying drugs. Methods: A modified Delphi consensus process (October 2017–June 2018) was used to develop clinically relevant recommendations for making decisions about vaccinations in patients with MS. A series of statements and recommendations regarding the efficacy, safety and timing of vaccine administration in patients with MS were generated in April 2018 by a panel of experts based on a review of the published literature performed in October 2017. Results: Recommendations include the need for an ‘infectious diseases card’ of each patient’s infectious and immunisation history at diagnosis in order to exclude and eventually treat latent infections. We suggest the implementation of the locally recommended vaccinations, if possible at MS diagnosis, otherwise with vaccination timing tailored to the planned/current MS treatment, and yearly administration of the seasonal influenza vaccine regardless of the treatment received. Conclusion: Patients with MS should be vaccinated with careful consideration of risks and benefits. However, there is an urgent need for more research into vaccinations in patients with MS to guide evidence-based decision making.

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Too Fit To Fracture: outcomes of a Delphi consensus process on physical activity and exercise recommendations for adults with osteoporosis with or without vertebral fractures

Osteoporosis International ◽

10.1007/s00198-014-2881-4 ◽

2014 ◽

Vol 26 (3) ◽

pp. 891-910 ◽

Cited By ~ 47

Author(s):

L. M. Giangregorio ◽

S. McGill ◽

J. D. Wark ◽

J. Laprade ◽

A. Heinonen ◽

...

Keyword(s):

Physical Activity ◽

Vertebral Fractures ◽

Delphi Consensus ◽

Consensus Process ◽

Physical Activity And Exercise

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Surgical treatment of brainstem cavernous malformations: an international Delphi consensus

Journal of Neurosurgery ◽

10.3171/2021.3.jns2156 ◽

2021 ◽

pp. 1-11

Author(s):

Philipp Dammann ◽

Adib A. Abla ◽

Rustam Al-Shahi Salman ◽

Hugo Andrade-Barazarte ◽

Vladimir Benes ◽

...

Keyword(s):

Surgical Treatment ◽

Case Series ◽

Treatment Decision ◽

Clinical Situation ◽

Delphi Consensus ◽

Consensus Process ◽

Cavernous Malformations ◽

Clinical Scenarios ◽

Developmental Venous Anomalies ◽

Question Survey

OBJECTIVE Indication for surgery in brainstem cavernous malformations (BSCMs) is based on many case series, few comparative studies, and no randomized controlled trials. The objective of this study was to seek consensus about surgical management aspects of BSCM. METHODS A total of 29 experts were invited to participate in a multistep Delphi consensus process on the surgical treatment of BSCM. RESULTS Twenty-two (76%) of 29 experts participated in the consensus. Qualitative analysis (content analysis) of an initial open-ended question survey resulted in 99 statements regarding surgical treatment of BSCM. By using a multistep survey with 100% participation in each round, consensus was reached on 52 (53%) of 99 statements. These were grouped into 4 categories: 1) definitions and reporting standards (7/14, 50%); 2) general and patient-related aspects (11/16, 69%); 3) anatomical-, timing of surgery–, and BSCM-related aspects (22/37, 59%); and 4) clinical situation–based decision-making (12/32, 38%). Among other things, a consensus was reached for surgical timing, handling of associated developmental venous anomalies, handling of postoperative BSCM remnants, assessment of specific anatomical BSCM localizations, and treatment decisions in typical clinical BSCM scenarios. CONCLUSIONS A summary of typical clinical scenarios and a catalog of various BSCM- and patient-related aspects that influence the surgical treatment decision have been defined, rated, and interpreted.

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Core Outcome Domains for Controlled Trials and Clinical Recordkeeping in Eczema: International Multiperspective Delphi Consensus Process

Journal of Investigative Dermatology ◽

10.1038/jid.2010.303 ◽

2011 ◽

Vol 131 (3) ◽

pp. 623-630 ◽

Cited By ~ 107

Author(s):

Jochen Schmitt ◽

◽

Sinéad Langan ◽

Tanja Stamm ◽

Hywel C. Williams

Keyword(s):

Controlled Trials ◽

Core Outcome ◽

Delphi Consensus ◽

Consensus Process

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Developing a Preliminary Definition and Domains of Flare in Knee and Hip Osteoarthritis (OA): Consensus Building of the Flare-in-OA OMERACT Group

The Journal of Rheumatology ◽

10.3899/jrheum.181085 ◽

2019 ◽

Vol 46 (9) ◽

pp. 1188-1191 ◽

Cited By ~ 4

Author(s):

Francis Guillemin ◽

Camille Ricatte ◽

Annica Barcenilla-Wong ◽

Amandine Schoumacker ◽

Marita Cross ◽

...

Keyword(s):

Content Analysis ◽

Focus Group ◽

Health Professionals ◽

Hip Osteoarthritis ◽

Consensus Building ◽

Delphi Consensus ◽

Focus Group Interviews ◽

Link Type ◽

Group Interviews ◽

Definition Of

Flare in knee and hip osteoarthritis (OA) is more than just an exacerbation of pain. Unstructured, semistructured, and focus group interviews followed by Delphi surveys with patients and health professionals (HP) generated candidate domains of an OA flare. Content analysis of interviews with 29 patients and 16 HP extracted 180 statements, which were grouped into 9 clusters. Delphi consensus with 50 patients (Australia, Canada, and France) and 116 HP (17 countries on 4 continents) identified 5 flare domains: pain, swelling, stiffness, psychological aspects, and effect of symptoms. Elements for a preliminary definition of an OA flare are proposed. Registered at clinicaltrials.govNCT02892058.

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