A Strain-Based Model for Mechanical Hemolysis Based on a Coarse-Grained Red Blood Cell Model

2015 ◽  
Vol 43 (6) ◽  
pp. 1398-1409 ◽  
Author(s):  
Hussein M. Ezzeldin ◽  
Marco D. de Tullio ◽  
Marcos Vanella ◽  
Santiago D. Solares ◽  
Elias Balaras
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Coarse Grained

scholarly journals Modeling Red Blood Cell Viscosity Contrast Using Inner Soft Particle Suspension

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 974
Author(s):  
Alžbeta Bohiniková ◽  
Iveta Jančigová ◽  
Ivan Cimrák
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Coarse Grained ◽  
Particle Suspension ◽  
Soft Particle ◽  
Particle Interactions ◽  
Virtual Cluster ◽  
Dissipative Forces ◽  
Viscosity Contrast

The inner viscosity of a biological red blood cell is about five times larger than the viscosity of the blood plasma. In this work, we use dissipative particles to enable the proper viscosity contrast in a mesh-based red blood cell model. Each soft particle represents a coarse-grained virtual cluster of hemoglobin proteins contained in the cytosol of the red blood cell. The particle interactions are governed by conservative and dissipative forces. The conservative forces have purely repulsive character, whereas the dissipative forces depend on the relative velocity between the particles. We design two computational experiments that mimic the classical viscometers. With these experiments we study the effects of particle suspension parameters on the inner cell viscosity and provide parameter sets that result in the correct viscosity contrast. The results are validated with both static and dynamic biological experiment, showing an improvement in the accuracy of the original model without major increase in computational complexity.

A Red Blood Cell Model to Estimate the Hemolysis Fingerprint of Cardiovascular Devices

2017 ◽  
Vol 42 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Riccardo Toninato ◽  
Giuseppe Fadda ◽  
Francesca Maria Susin
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Cardiovascular Devices

scholarly journals Numerical simulations of blood cell flow in non-Newtonian fluid

2020 ◽  
Vol 306 ◽  
pp. 01006
Author(s):  
Kazuhiro Shitara ◽  
Toru Hyakutake
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Newtonian Fluid ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Cell Model ◽  
Flow Behavior ◽  
Shear Thinning ◽  
Mutual Interference ◽  
Axial Concentration

We investigated how non-Newtonian viscosity behavior affects the flow characteristics of blood cells. Our findings offer insight about how shear thinning affects the dispersion of liposome-encapsulated hemoglobin and red blood cells in blood. The lattice Boltzmann method was used for fluid calculations, and the rheological properties of the non-Newtonian fluid were modeled with power-law relationships. The deformable three-dimensional red blood cell model was applied. First, we investigated the effects of shear thinning on the flow behavior of single blood cell. Simulation results indicate that shear thinning promotes the axial concentration of red blood cells. Next, varied the hematocrit to see how mutual interference between blood cells affects flow. At low hematocrit, shear thinning clearly promotes the axial concentration of red blood cells. As the hematocrit increases, in contrast, mutual interference has a greater effect, which counteracts shear thinning so the red blood cell distribution resembles the distribution within a Newtonian fluid.

scholarly journals Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

2016 ◽  
Vol 12 (5) ◽  
pp. 1564-1573 ◽  
Author(s):  
A. de Almeida ◽  
A. P. Martins ◽  
A. F. Mósca ◽  
H. J. Wijma ◽  
C. Prista ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Aquaporin 3 ◽  
Gating Mechanisms ◽  
First Time

The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC).

Coarse-Grained Molecular Dynamics Simulation of a Red Blood Cell

2010 ◽  
Vol 27 (2) ◽  
pp. 028704 ◽  
Author(s):  
Jiang Li-Guo ◽  
Wu Heng-An ◽  
Zhou Xiao-Zhou ◽  
Wang Xiu-Xi
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Dynamics Simulation ◽  
Coarse Grained ◽  
Coarse Grained Molecular Dynamics
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