scholarly journals Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

2016 ◽  
Vol 12 (5) ◽  
pp. 1564-1573 ◽  
Author(s):  
A. de Almeida ◽  
A. P. Martins ◽  
A. F. Mósca ◽  
H. J. Wijma ◽  
C. Prista ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Aquaporin 3 ◽  
Gating Mechanisms ◽  
First Time

The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC).

A Red Blood Cell Model to Estimate the Hemolysis Fingerprint of Cardiovascular Devices

2017 ◽  
Vol 42 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Riccardo Toninato ◽  
Giuseppe Fadda ◽  
Francesca Maria Susin
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Cardiovascular Devices

scholarly journals Numerical simulations of blood cell flow in non-Newtonian fluid

2020 ◽  
Vol 306 ◽  
pp. 01006
Author(s):  
Kazuhiro Shitara ◽  
Toru Hyakutake
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Newtonian Fluid ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Cell Model ◽  
Flow Behavior ◽  
Shear Thinning ◽  
Mutual Interference ◽  
Axial Concentration

We investigated how non-Newtonian viscosity behavior affects the flow characteristics of blood cells. Our findings offer insight about how shear thinning affects the dispersion of liposome-encapsulated hemoglobin and red blood cells in blood. The lattice Boltzmann method was used for fluid calculations, and the rheological properties of the non-Newtonian fluid were modeled with power-law relationships. The deformable three-dimensional red blood cell model was applied. First, we investigated the effects of shear thinning on the flow behavior of single blood cell. Simulation results indicate that shear thinning promotes the axial concentration of red blood cells. Next, varied the hematocrit to see how mutual interference between blood cells affects flow. At low hematocrit, shear thinning clearly promotes the axial concentration of red blood cells. As the hematocrit increases, in contrast, mutual interference has a greater effect, which counteracts shear thinning so the red blood cell distribution resembles the distribution within a Newtonian fluid.

scholarly journals Probing red blood cell mechanics, rheology and dynamics with a two-component multi-scale model

2014 ◽  
Vol 372 (2021) ◽  
pp. 20130389 ◽  
Author(s):  
Xuejin Li ◽  
Zhangli Peng ◽  
Huan Lei ◽  
Ming Dao ◽  
George Em Karniadakis
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Microfluidic Channel ◽  
Scale Model ◽  
Cross Sectional ◽  
Whole Cell ◽  
Multi Scale ◽  
Rbc Membrane ◽  
Two Component

This study is partially motivated by the validation of a new two-component multi-scale cell model we developed recently that treats the lipid bilayer and the cytoskeleton as two distinct components. Here, the whole cell model is validated and compared against several available experiments that examine red blood cell (RBC) mechanics, rheology and dynamics. First, we investigated RBC deformability in a microfluidic channel with a very small cross-sectional area and quantified the mechanical properties of the RBC membrane. Second, we simulated twisting torque cytometry and compared predicted rheological properties of the RBC membrane with experimental measurements. Finally, we modelled the tank-treading (TT) motion of a RBC in a shear flow and explored the effect of channel width variation on the TT frequency. We also investigated the effects of bilayer–cytoskeletal interactions on these experiments and our simulations clearly indicated that they play key roles in the determination of cell membrane mechanical, rheological and dynamical properties. These simulations serve as validation tests and moreover reveal the capabilities and limitations of the new whole cell model.

Red Blood Cell Model Validation in Dynamic Regime

2018 ◽  
pp. 259-269 ◽  
Author(s):  
Kristína Kovalčíková ◽  
Alžbeta Bohiniková ◽  
Martin Slavík ◽  
Isabelle Mazza Guimaraes ◽  
Ivan Cimrák
Keyword(s):  
Blood Cell ◽  
Model Validation ◽  
Red Blood Cell ◽  
Cell Model ◽  
Dynamic Regime

A Strain-Based Model for Mechanical Hemolysis Based on a Coarse-Grained Red Blood Cell Model

2015 ◽  
Vol 43 (6) ◽  
pp. 1398-1409 ◽  
Author(s):  
Hussein M. Ezzeldin ◽  
Marco D. de Tullio ◽  
Marcos Vanella ◽  
Santiago D. Solares ◽  
Elias Balaras
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Model ◽  
Coarse Grained
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