Effect of Polidan on ultrastructural changes in the cerebral cortex and hippocampus of rats

2006 ◽  
Vol 142 (2) ◽  
pp. 254-259
Author(s):  
V. S. Kaptar’ ◽  
O. V. Kurskaya ◽  
N. A. Tushmalova ◽  
L. L. Pragina ◽  
E. V. Loseva
Keyword(s):  
Cerebral Cortex ◽  
Ultrastructural Changes

Brain lactic acidosis and ischemic cell damage: Quantitative ultrastructural changes in capillaries of rat cerebral cortex

1983 ◽  
Vol 60 (3-4) ◽  
pp. 232-240 ◽  
Author(s):  
L. Palj�rvi ◽  
S. Rehncrona ◽  
B. S�derfeldt ◽  
Y. Olsson ◽  
H. Kalimo
Keyword(s):  
Cerebral Cortex ◽  
Lactic Acidosis ◽  
Cell Damage ◽  
Rat Cerebral Cortex ◽  
Ultrastructural Changes

scholarly journals Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats

2009 ◽  
Vol 2009 ◽  
pp. 1-12 ◽  
Author(s):  
Juan P. Hernández-Fonseca ◽  
Jaimar Rincón ◽  
Adriana Pedreañez ◽  
Ninoska Viera ◽  
José L. Arcaya ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Depressive Mood ◽  
Diabetic Rats ◽  
Ultrastructural Changes ◽  
Central Nervous System Damage ◽  
Morphological Alterations ◽  
Brain Functions ◽  
Structural Abnormalities ◽  
Streptozotocin Induced Diabetes ◽  
Presynaptic Vesicle

Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities. In addition, depressive mood was observed in diabetic animals. The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral.

The HIV-1 gp120 causes ultrastructural changes typical of apoptosis in the rat cerebral cortex

Neuroreport ◽  
1996 ◽  
Vol 7 (11) ◽  
pp. 1722-1724 ◽  
Author(s):  
G. Bagetta ◽  
M. T. Corasaniti ◽  
W. Malorni ◽  
G. Rainaldi ◽  
L. Berliocchi ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Rat Cerebral Cortex ◽  
Ultrastructural Changes ◽  
Hiv 1

Ultrastructural Changes of Blood Vessels in the Cerebral Cortex in Alzheimer's Disease

1987 ◽  
Vol 41 (2) ◽  
pp. 283-290 ◽  
Author(s):  
Yasushi Higuchi ◽  
Taihei Miyakawa ◽  
Akitomo Shimoji ◽  
Shoichi Katsuragi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Blood Vessels ◽  
Ultrastructural Changes

scholarly journals Differential expression of glycogen synthase kinase 3α and 3β isomers in brain cortex of mice following high doses of glucose

2020 ◽  
Vol 11 (1) ◽  
pp. 993-999
Author(s):  
Mohd Alaraj ◽  
Irena Kosinska ◽  
Bahaa Deen Al-Trad ◽  
Ammar Almaaytah ◽  
Tarek D. Hussein ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Cortex ◽  
Mitochondrial Dysfunction ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Ultrastructural Changes ◽  
Histopathological Analysis ◽  
Modulation Of Gene Expression ◽  
High Doses

Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine protein kinase. We investigated the effects of Subcutaneous (SC) glucose administration on the expression of glycogen synthase kinase 3 (GKS-3) isomers (α and β) genes in the cerebral cortex of mice with the aim of determining the possible mechanism(s) involved in mitochondrial dysfunction induced by hyperglycemia. Adult male BALB/c mice were treated with 12 gm/kg glucose solution SC once daily for 3 days. Ultrastructure study, histopathological analysis, and Real-time PCR investigations were carried out on the cerebral cortex from glucose treated mice and from vehicle-treated control animals. We observed significant ultrastructural damage of mitochondria in the cerebral cortex of mice received high doses of glucose. Histopathological alterations in the cortex of these animals were also detected. A significant increased of GSK-3α gene expression and decreased expressions of GKS-3β gene in high glucose treated animals were noticed. The hyperglycemia-induced ultrastructural changes may occur via modulation of gene expression of GSK-3 isomers, and we hypothesize this as an early etiopathological factor in hyperglycemia-related neurodegenerative diseases (NDD). It considered the first study describing "modulation of expression of GSK-3 isomer genes" as a possible mechanism of hyperglycemia-induced mitochondrial dysfunction.

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