Phenotype of Peripheral Blood Cells Mobilized by Granulocyte Colony-Stimulating Factor in Patients with Chronic Heart Failure

2012 ◽  
Vol 153 (1) ◽  
pp. 124-128 ◽  
Author(s):  
V. I. Konenkov ◽  
E. A. Pokushalov ◽  
O. V. Poveshchenko ◽  
I. I. Kim ◽  
A. B. Romanov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Efficacy of G-CSF mobilization CD34+ progenitor cells depending on ischemic history and age of patients with chronic heart failure

2018 ◽  
Vol 16 (1) ◽  
pp. 75
Author(s):  
I. I. Kim ◽  
O. V. Poveshchenko ◽  
V. I. Konenkov ◽  
Ye. A. Pokushalov ◽  
A. B. Romanov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Progenitor Cells ◽  
Peripheral Blood ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Heart Attacks ◽  
Time Period ◽  
Cd34 Cells ◽  
Stimulating Factor

It is shown that administration of G-CSF (Granulocyte Colony Stimulating Factor) to patients with chronic heart failure has a gematologic effect, while increasing the number of leukocytes and neutrophils in the peripheral blood. G-CSF leads to mobilization of progenitor cells (PCs) from the bone marrow into the peripheral blood. The basal content of CD34+ cells, the number of heart attacks and the time period from the last myocardial infarction effect the number of CD34+ cells after mobilization.

scholarly journals Functional characteristics of peripheral blood mononuclear cells after administration of granulocyte colony-stimulating factor in patients with chronic heart failure

2015 ◽  
Vol 18 (1) ◽  
pp. 26
Author(s):  
O. V. Poveshchenko ◽  
I. I. Kim ◽  
N. A. Bondarenko ◽  
A. P. Lykov ◽  
A. F. Poveshchenko ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Stimulating Factor

It is shown that the introduction of granulocyte colony stimulating factor (G-CSF) in patients with chronic heart failure increases the functional activity of peripheral blood mononuclear cells (MNC). Enriching peripheral blood MNCs with progenitor cells (PC) by mobilization of bone marrow leads to an increase of their proliferative capacity both under spontaneous culture conditions and when stimulated with ConA mitogen and cytokines G-CSF. Proliferative activity of MNCs is found to increase, as the number of CD34+ PC starts growing. It is also noted that MNCs produce a wide range of cytokines with regulatory action after mobilization in a 48-hour culture in vitro. The findings suggest the feasibility of using MNCs after G-CSF mobilization for stimulation of reparative processes in the myocardium.

scholarly journals Production of colony-stimulating factor by leukemic leukocytes

Blood ◽  
1976 ◽  
Vol 47 (3) ◽  
pp. 381-388 ◽  
Author(s):  
JM Goldman ◽  
KH Th'ng ◽  
D Catovsky ◽  
DA Galton
Keyword(s):  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells ◽  
Colony Stimulating Factor ◽  
Monocytic Leukemia ◽  
Agar Culture ◽  
Normal Peripheral Blood ◽  
Stimulating Factor ◽  
Csf Production

The production of colony-stimulating factor (CSF) by the peripheral blood cells of untreated patients with acute myeloid leukemia (AML) was measured in the agar culture system using normal human bone marrow as the source of colony-forming units (CFUc). CSF production was found to be variable and was related to the morphologic subtype of AML--cells from patients with monocytic leukemia produced normal or large quantities of CSF, while (with one exception) those from patients with myeloblastic leukemia produced little or no CSF. There was a general relationship between CSF production and serum lysozyme levels. Attempts to demonstrate a consistent inhibitory effect exerted by leukemic peripheral blood cells on normal leukopoiesis in vitro were negative. Results instead suggested that the addition to the feeder layer of cells from patients with monocytic leukemia could raise CSF levels above those obtained with normal peripheral blood leukocytes alone, possibly by recruiting additional CFUc from normal marrow.

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