Mortality outcome among medically underserved women screened through a publicly funded breast cancer control program, 1997–2007

2014 ◽  
Vol 146 (1) ◽  
pp. 221-227 ◽  
Author(s):  
Soumitra Sudip Bhuyan ◽  
Jim P. Stimpson ◽  
Shireen S. Rajaram ◽  
Ge Lin
2019 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Cabanes ◽  
Sharon Kapambwe ◽  
Susan Citonje-Msadabwe ◽  
Groesbeck P. Parham ◽  
Kennedy Lishimpi ◽  
...  

In 2016, the Zambian government made cancer control a national priority and released a National Cancer Control Strategic Plan for 2016 to 2021, which focuses on malignancies of the breast, cervix, and prostate, and retinoblastoma. The plan calls for a collective reduction in the cancer burden by 50%. In support of this vision, Susan G. Komen sponsored a consultative meeting in Lusaka, Zambia, in September 2017 to bring together the country’s main breast cancer stakeholders and identify opportunities to improve breast cancer control. The recommendations generated during the discussions are presented. There was general agreement that the first step toward breast cancer mortality reduction should consist of implementation of early detection service platforms focused on women who are symptomatic. Participants also agreed that the management of all components of the national breast cancer control program should be integrated and led by the Ministry of Health. As much as possible, early detection and treatment services presently offered by the Cervical Cancer Prevention Program of Zambia and Cancer Diseases Hospital should be leveraged. Efforts are under way through multiple stakeholders to implement the following recommendations: development of national guidelines for the early diagnosis of breast cancer, training of breast surgeons, implementation of early detection and surgical treatment service platforms at the district-hospital level, and epidemiologic research, including the improvement of electronic recording mechanisms.


2009 ◽  
Vol 24 (4) ◽  
pp. 257-260 ◽  
Author(s):  
Karen Patricia Williams ◽  
Athur Mabiso ◽  
Tedra Jackson ◽  
Dorothy Lawshe ◽  
Joel Maurer

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 519
Author(s):  
Ewelina Szczerba ◽  
Katarzyna Kamińska ◽  
Tomasz Mierzwa ◽  
Marcin Misiek ◽  
Janusz Kowalewski ◽  
...  

(1) Background: Although, in the mutated BRCA detected in the Polish population of patients with breast cancer, there is a large percentage of recurrent pathogenic variants, an increasing need for the assessment of rare BRCA1/2 variants using NGS can be observed. (2) Methods: We studied 75 selected patients with breast cancer (negative for the presence of 5 mutations tested in the Polish population in the prophylactic National Cancer Control Program). DNA extracted from the cancer tissue of these patients was used to prepare a library and to sequence all coding regions of the BRCA1/2 genes. (3) Results: We detected nine pathogenic variants in 8 out of 75 selected patients (10.7%). We identified one somatic and eight germline variants. We also used different bioinformatic NGS software programs to analyze NGS FASTQ files and established that tertiary analysis performed with different tools was more likely to give the same outcome if we analyzed files received from secondary analysis using the same method. (4) Conclusions: Our study emphasizes (i) the importance of an NGS validation process with a bioinformatic procedure included; (ii) the importance of screening both somatic and germline pathogenic variants; (iii) the urgent need to identify additional susceptible genes in order to explain the high percentage of non-BRCA-related hereditary cases of breast cancer.


2021 ◽  
pp. 100281
Author(s):  
Dorothy Lombe ◽  
Susan Msadabwe ◽  
Mbaita Maka ◽  
Memory Samboko ◽  
Prudence Haimbe ◽  
...  

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