Quality control of human tissues-experience from the Indiana University Cancer Center-Lilly Research Labs human tissue bank

2007 ◽  
Vol 8 (4) ◽  
pp. 287-295 ◽  
Author(s):  
George E. Sandusky ◽  
Katie Heinz Teheny ◽  
Mike Esterman ◽  
Jeff Hanson ◽  
Stephen D. Williams
Keyword(s):  
Quality Control ◽  
Human Tissue ◽  
Tissue Bank ◽  
Cancer Center ◽  
Human Tissues ◽  
Indiana University

Cancer Patients' Attitudes toward Future Research Uses of Stored Human Biological Materials

2007 ◽  
Vol 2 (3) ◽  
pp. 15-22 ◽  
Author(s):  
Paul R. Helft ◽  
Victoria L. Champion ◽  
Rachael Eckles ◽  
Cynthia S. Johnson ◽  
Eric M. Meslin
Keyword(s):  
Cancer Patients ◽  
Tissue Bank ◽  
Mail Survey ◽  
Biological Materials ◽  
Survey Study ◽  
Cancer Center ◽  
Future Research ◽  
Policy Debate ◽  
Indiana University ◽  
Tissue Specimens

The policy debate concerning informed consent for future, unspecified research of stored human biological materials (HBM) would benefit from an understanding of the attitudes of individuals who contribute tissue specimens to HBM repositories. Cancer patients who contributed leftover tissue to the Indiana University Cancer Center Tissue Bank under such conditions were recruited for a mail survey study of their attitudes. Our findings suggest that a clear majority of subjects would permit unlimited future research on stored HBMs without re-contact and re-consent, and a significant minority appear to desire ongoing control over future research uses of their tissue. These differences merit further investigation and suggest that a policy of blanket consent for all future, unspecified research would be premature.

Recommended Policies for Uses of Human Tissue in Research, Education, and Quality Control

1999 ◽  
Vol 123 (4) ◽  
pp. 296-300 ◽  
Author(s):  
William Grizzle ◽  
Wayne W. Grody ◽  
Walter W. Noll ◽  
Mark E. Sobel ◽  
Sanford A. Stass ◽  
...  
Keyword(s):  
Quality Control ◽  
Human Tissue ◽  
Medical Knowledge ◽  
Best Interests ◽  
Direct Patient Care ◽  
Research Education ◽  
The Public ◽  
Medical Specialists ◽  
The Individual ◽  
Knowledge Interests

Abstract As recipients of tissue and medical specimens, pathologists and other medical specialists regard themselves as stewards of patient tissues and consider it their duty to protect the best interests of both the individual patient and the public. The stewardship of slides, blocks, and other materials includes providing, under appropriate circumstances, patient materials for research, education, and quality control. The decision to provide human tissue for such purposes should be based on the specific (ie, direct patient care) and general (ie, furthering medical knowledge) interests of the patient and of society. The same standards of responsibility should apply to all medical professionals who receive and use specimens. This document proposes specific recommendations whereby both interests can be fostered safely, ethically, and reasonably.

Implementation and certification of ISO 9001:2015 seal in human tissue bank HCFMRP-USP

2020 ◽  
Vol 21 (4) ◽  
pp. 563-571
Author(s):  
Carlos Alexandre Curylofo Corsi ◽  
Mitsuhisa Shoji ◽  
Katia Carmen Gabriel Scarpelini ◽  
Rodolfo Leandro Bento ◽  
Christiane Becari ◽  
...  
Keyword(s):  
Human Tissue ◽  
Tissue Bank ◽  
Iso 9001

scholarly journals Comprehensive identification of alternative back-splicing in human tissue transcriptomes

2020 ◽  
Vol 48 (4) ◽  
pp. 1779-1789 ◽  
Author(s):  
Peng Zhang ◽  
Xiao-Ou Zhang ◽  
Tingting Jiang ◽  
Lingling Cai ◽  
Xiao Huang ◽  
...  
Keyword(s):  
Splice Site ◽  
Human Tissue ◽  
Single Gene ◽  
Brain Regions ◽  
Intron Length ◽  
Circular Rnas ◽  
Human Tissues ◽  
Alu Elements ◽  
Depth Analysis ◽  
Brain Tissues

Abstract Circular RNAs (circRNAs) are covalently closed RNAs derived from back-splicing of genes across eukaryotes. Through alternative back-splicing (ABS), a single gene produces multiple circRNAs sharing the same back-splice site. Although many ABS events have recently been discovered, to what extent ABS involves in circRNA biogenesis and how it is regulated in different human tissues still remain elusive. Here, we reported an in-depth analysis of ABS events in 90 human tissue transcriptomes. We observed that ABS occurred for about 84% circRNAs. Interestingly, alternative 5′ back-splicing occurs more prevalently than alternative 3′ back-splicing, and both of them are tissue-specific, especially enriched in brain tissues. In addition, the patterns of ABS events in different brain regions are similar to each other and are more complex than the patterns in non-brain tissues. Finally, the intron length and abundance of Alu elements positively correlated with ABS event complexity, and the predominant circRNAs had longer flanking introns and more Alu elements than other circRNAs in the same ABS event. Together, our results represent a resource for circRNA research—we expanded the repertoire of ABS events of circRNAs in human tissue transcriptomes and provided insights into the complexity of circRNA biogenesis, expression, and regulation.

Human Research Tissue Banks: The ATRA Project for Establishing a Human Research Tissue Bank in Switzerland

2005 ◽  
Vol 33 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Massimo Tettamanti ◽  
Sara Tralamazza ◽  
Marina Berati ◽  
Max Molteni ◽  
Natascia Gamba
Keyword(s):  
Biomedical Research ◽  
Human Tissue ◽  
Tissue Bank ◽  
Animal Origin ◽  
Tissue Banks ◽  
Research Needs ◽  
Human Research ◽  
Human Organs ◽  
Human Material ◽  
Treatment And Disposal

A large number of experiments in biomedical research are carried out on tissues, but, even though the results should be applicable to humans, these tissues are mainly of animal origin. The difficulty encountered in obtaining human organs and tissues is an acknowledged problem: not enough human tissues are available to meet research needs. We are introducing the ATRA Project, with the purpose of supporting progress in biomedical research in Switzerland through the establishment of one or more human tissue banks, which will be able to find, treat, preserve and supply human material. Where similar projects have already been launched, concerns have been expressed that donation for research purposes might compete with donation for transplantation, but most organs and tissues are in any case non-transplantable. Surplus surgical tissue is considered “sanitary waste”, and must be treated according to specific regulations for collection, packaging, transport, treatment and disposal. A human tissue bank would not only abate the costs of treating sanitary waste, but would actually turn what is now considered waste into a resource which could be used to save human and animal lives.

scholarly journals Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot

Biology ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 59 ◽  
Author(s):  
Magali Humbert ◽  
María Morán ◽  
Patricia de la Cruz-Ojeda ◽  
Jordi Muntané ◽  
Tabea Wiedmer ◽  
...  
Keyword(s):  
Human Tissue ◽  
Degradation Mechanism ◽  
Autophagic Flux ◽  
Human Tissues ◽  
Tissue Analysis ◽  
Therapeutic Approaches ◽  
Tissue Samples ◽  
Clear Cut ◽  
Autophagic Activity ◽  
Made In

Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches. Accordingly, there is a need to determine autophagic activity in human tissues, an endeavor that is hampered by the fact that autophagy is characterized by the flux of substrates whereas histology informs only about amounts and localization of substrates and regulators at a single timepoint. Despite this challenging task, considerable progress in establishing markers of autophagy has been made in recent years. The importance of establishing clear-cut autophagy markers that can be used for tissue analysis cannot be underestimated. In this review, we attempt to summarize known techniques to quantify autophagy in human tissue and their drawbacks. Furthermore, we provide some recommendations that should be taken into consideration to improve the reliability and the interpretation of autophagy biomarkers in human tissue samples.

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