Two new compounds and other constituents from Cassia fistula root bark

2013 ◽  
Vol 49 (2) ◽  
pp. 232-234 ◽  
Author(s):  
Nishant Kumar Jain ◽  
Satish Chandra Jain ◽  
Renuka Jain
Keyword(s):  
Root Bark ◽  
Cassia Fistula ◽  
New Compounds

scholarly journals Cytotoxic Prenylated Polyphenolic Compounds from Maackia amurensis Root Bark

2017 ◽  
Vol 12 (7) ◽  
pp. 1934578X1701200
Author(s):  
Marina V. Veselova ◽  
Sergey A. Fedoreyev ◽  
Darya V. Tarbeeva ◽  
Nadezda I. Kulesh ◽  
Anatoliy I. Kalinovskiy ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Hela Cells ◽  
Human Cancer ◽  
Polyphenolic Compounds ◽  
Root Bark ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Maackia Amurensis ◽  
New Compounds

Two new prenylated flavanones, isomaackiaflavanone A (1), isomaackiaflavanone B (2) and a new prenylated stilbene maackiastilbene (3), along with five known flavanones were isolated from the root bark of Maackia amurensis using repeated column chromatography on silica gel, Sephadex LH-20 and octadecyl silica (ODS-A) sorbents. The structures of the new compounds were elucidated by HPLC–PDA–MS, HR-ESI-MS, 1H, 13C, 1H–1H COSY, HSQC, ROESY and HMBC NMR analyses. The cytotoxicity of compounds 1–2, 4–8 against two human cancer cell lines HeLa and SK-MEL-5 was tested using the MTS method. Compounds 4, 6 and 8 showed the strongest cytotoxic activity among the compounds tested with IC50 values of 6.5, 8.8 and 7.7 μM, against SK-MEL-5 cells and 8.2, 18.8 and 12 μM against HeLa cells, respectively.

scholarly journals Two 2-Phenylbenzofuran Derivatives from Morus atropurpurea

2013 ◽  
Vol 8 (5) ◽  
pp. 1934578X1300800
Author(s):  
Wen-Jing Wang ◽  
Dong-Ling Wu ◽  
Sen-Tai Liao ◽  
Chun-Lin Fan ◽  
Li Guo-Qiang ◽  
...  
Keyword(s):  
Root Bark ◽  
Esi Ms ◽  
New Compounds

Two new 2-phenylbenzofuran derivatives, atrofuran A (1) and atrofuran B (2), along with five known compounds, were isolated from the root bark of Morus atropurpurea. The structures of the new compounds were determined on the basis of extensive NMR spectroscopic and HR-ESI-MS analyses.

New Isoflavonoids from Root Bark of Kowhai Sophora microphylla)

1997 ◽  
Vol 50 (4) ◽  
pp. 333 ◽  
Author(s):  
Graeme B. Russell Horticultural
Keyword(s):  
Spectroscopic Analysis ◽  
Root Bark ◽  
New Compounds

Two new isoflavanones, phyllanone A (1) and phyllanone B (2), together with the known isoflavonoids isosophoranone (3), maackiain (4), medicagol (5) and lupalbigenin (6), have been isolated from the root bark ofSophora microphylla. The structures and chirality of the new compounds have been determined from spectroscopic analysis.

Three new compounds from the dried root bark of Wikstroemia indica and their cytotoxicity against HeLa cells

2021 ◽  
pp. 1-8
Author(s):  
Peixin Shi ◽  
Zhihui Liu ◽  
Ruyue Cen ◽  
Caihui Mao ◽  
Na Han ◽  
...  
Keyword(s):  
Hela Cells ◽  
Root Bark ◽  
New Compounds

Four Additional Meroterpenes Produced by Penicillium sp Found in Association with Melia azedarach. Possible Biosynthetic Intermediates to Austin

2007 ◽  
Vol 62 (8) ◽  
pp. 1035-1044 ◽  
Author(s):  
Taicia Pacheco Fill ◽  
Grace Kelli Pereira ◽  
Regina M. Geris dos Santos ◽  
Edson Rodrigues-Fo
Keyword(s):  
Nmr Spectroscopy ◽  
Spectroscopic Studies ◽  
Melia Azedarach ◽  
Root Bark ◽  
Penicillium Sp ◽  
New Compounds

Four additional meroterpenes were isolated and identified from rice cultures of Penicillium sp, a fungus obtained from the root bark of Melia azedarach. These new compounds were named preaustinoid B2 (1), preaustinoid A3 (2), austinolide (3), and isoaustinone (4) in analogy with the formerly described compounds. The structures were identified by extensive spectroscopic studies, including 1 D and 2 D NMR spectroscopy and HRMS. Compounds 1 - 4 are probably biosynthetic intermediates to Austin.

scholarly journals Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

RSC Advances ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 805-812 ◽  
Author(s):  
Ya-Nan Yang ◽  
Ya-Wen An ◽  
Zhi-Lai Zhan ◽  
Jing Xie ◽  
Jian-Shuang Jiang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Root Bark ◽  
Lycium Chinense ◽  
New Compounds ◽  
Solanaceae Family ◽  
Deciduous Shrub

Lycium chinense Mill. is a deciduous shrub in the Solanaceae family that is known for its fruits (Lycii fructus) and root bark (Lycii cortex).

scholarly journals Terpenoids from Turraeanthus species

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501
Author(s):  
Juliette Catherine Vardamides ◽  
Valerie Tedjon Sielinou ◽  
Sergi Herve Akone ◽  
Augustin Ephrem Nkengfack ◽  
Berhanu M. Abegaz
Keyword(s):  
Structure Elucidation ◽  
Chemical Investigation ◽  
Spectroscopic Techniques ◽  
Root Bark ◽  
New Compounds

Chemical investigation of the root bark of Turraeanthus mannii and the stem of T. longipes resulted in the isolation of two new diterpenes, 13-methyl-labda-8(17)-en-15-oic acid (1) and 13-(hydroxymethyl)-14-hydroxy- ent-labda-8(17)-en-15-oic acid (2), along with two known diterpenes, 19-hydroxy- ent-labda-8(17),13-dien-15,16-olide (3) and 19-acetoxy- ent-labda-8(17),13-dien-15,16-olide (4), and the phytosterol, stigmasterol. The structure elucidation of the new compounds has been achieved using spectroscopic techniques.

scholarly journals Antiplasmodial Activity of the Ethnobotanical Plant Cassia fistula

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Mary H. Grace ◽  
Carmen Lategan ◽  
Rocky Graziose ◽  
Peter J. Smith ◽  
Ilya Raskin ◽  
...  
Keyword(s):  
Chinese Hamster ◽  
Chloroform Extract ◽  
Antiplasmodial Activity ◽  
Cassia Fistula ◽  
Leaf Extracts ◽  
Native Populations ◽  
Flash Column Chromatography ◽  
New Compounds ◽  
Line Compound

In our ongoing investigation of new compounds with activity against malaria parasites, we tested the in vitro antiplasmodial activity of fractions and purified compounds from Cassia fistula L., a plant traditionally used by native populations of Tanzania, Zimbabwe, Mozambique and Brazil to treat malaria or symptoms associated with this disease. Crude extracts from leaves, bark and fruits were tested for their antiplasmodial activity against the chloroquine-sensitive strain of Plasmodium falciparum(D10), where leaf extracts showed the highest activity. The chloroform extract of the leaves was further bioassay-guided fractionated using a combination of centrifugal partition chromatography and flash column chromatography. Three main antiplasmodial principles, phytol (1) (IC50 18.9 ± 0.60 μM), lutein (2) (IC50 12.5 ± 0.35 μM), and di-lineolylgalactopyranosyl-glycerol (DLGG) (IC50 5.8 ± 0.27 μM) (3), were isolated and identified using spectroscopic methods. When the three active principles were tested for their cytotoxicity using a Chinese Hamster Ovarian (CHO) cell line, compound 3 showed very weak toxicity (IC50 75.9 ± 0.28 μM), while the other two compounds were nontoxic, even at the highest concentration tested. The study provides evidence to support the use of Cassia fistula as an antimalarial remedy and describes the antiplasmodial constituents from the leaves.

Crystal chemistry of high-Tc superconductors

1990 ◽  
Vol 48 (4) ◽  
pp. 1118-1119
Author(s):  
Maryvonne Hervieu
Keyword(s):  
Oxygen Deficiency ◽  
Large Family ◽  
Copper Oxides ◽  
High Tc Superconductors ◽  
High Tc ◽  
Single Mechanism ◽  
Square Planar ◽  
History Of ◽  
Bismuth Cuprates ◽  
New Compounds

Four years after the discovery of superconductivity at high temperature in the Ba-La-Cu-O system, more than thirty new compounds have been synthesized, which can be classified in six series of copper oxides: La2CuO4 - type oxides, bismuth cuprates, YBa2Cu3O7 family, thallium cuprates, lead cuprates and Nd2CuO4 - type oxides. Despite their quite different specific natures, close relationships allow their structures to be simply described through a single mechanism. The fifth first families can indeed be described as intergrowths of multiple oxygen deficient perovskite slabs with multiple rock salt-type slabs, according to the representation [ACuO3-x]m [AO]n.The n and m values are integer in the parent structures, n varying from 0 to 3 and m from 1 to 4; every member of this large family can thus be symbolized by [m,n]. The oxygen deficient character of the perovskite slabs involves the existence or the co-existence of several types of copper environment: octahedral, pyramidal and square planar.Both mechanisms, oxygen deficiency and intergrowth, are well known to give rise easily to nonstoichiometry phenomena. Numerous and various phenomena have actually been characterized in these cuprates, strongly depending on the thermal history of the samples.

Evaluation of New Compounds for Opioid Activity: Annual Report (1993)

1994 ◽  
Author(s):  
J. C. Woods ◽  
◽  
C. P. France ◽  
F. Medzihradsky ◽  
C. B. Smith ◽  
...  
Keyword(s):  
Annual Report ◽  
Opioid Activity ◽  
New Compounds
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