scholarly journals Terpenoids from Turraeanthus species

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501
Author(s):  
Juliette Catherine Vardamides ◽  
Valerie Tedjon Sielinou ◽  
Sergi Herve Akone ◽  
Augustin Ephrem Nkengfack ◽  
Berhanu M. Abegaz
Keyword(s):  
Structure Elucidation ◽  
Chemical Investigation ◽  
Spectroscopic Techniques ◽  
Root Bark ◽  
New Compounds

Chemical investigation of the root bark of Turraeanthus mannii and the stem of T. longipes resulted in the isolation of two new diterpenes, 13-methyl-labda-8(17)-en-15-oic acid (1) and 13-(hydroxymethyl)-14-hydroxy- ent-labda-8(17)-en-15-oic acid (2), along with two known diterpenes, 19-hydroxy- ent-labda-8(17),13-dien-15,16-olide (3) and 19-acetoxy- ent-labda-8(17),13-dien-15,16-olide (4), and the phytosterol, stigmasterol. The structure elucidation of the new compounds has been achieved using spectroscopic techniques.

scholarly journals Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp.

Marine Drugs ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 171 ◽  
Author(s):  
Qi Wang ◽  
Xuli Tang ◽  
Hui Liu ◽  
Xiangchao Luo ◽  
Ping Jyun Sung ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Structure Elucidation ◽  
Soft Coral ◽  
Spectroscopic Techniques ◽  
Dependent Manner ◽  
Zebrafish Model ◽  
Chemical Examination ◽  
Xisha Islands ◽  
New Compounds ◽  
Dose Dependent

The chemical examination of the marine soft coral Lemnalia sp., collected at the Xisha islands in the South China Sea, resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely clavukoellians G–J (1–4), and one new aristolane sesquiterpene, namely clavukoellian K (5), together with five known compounds, 6–10. The structure elucidation of the isolated natural products was based on various spectroscopic techniques including HRESIMS and NMR, while their absolute configurations were resolved on the basis of comparisons of the ECD spectra with the calculated ECD data. The isolated new compounds 1–5 were evaluated for their anti- and pro- angiogenesis activities in a transgenic fluorescent zebrafish (Tg(vegfr2:GFP)) model. Quantitative analysis revealed that compound 5 displayed pro-angiogenesis activity in a PTK787-induced vascular injury zebrafish model at 2.5 μM. Data showed that compound 5 significantly promoted the angiogenesis in a dose-dependent manner.

scholarly journals 4-vinylpyridine derivatives: Protonation, methylation and silver(I) coordination chemistry

2021 ◽  
pp. 174751982198965
Author(s):  
Guoqi Zhang
Keyword(s):  
Mass Spectrometry ◽  
Schiff Base ◽  
Coordination Chemistry ◽  
Elemental Analysis ◽  
Silver Complex ◽  
Spectroscopic Techniques ◽  
X Ray ◽  
X Ray Crystallography ◽  
Pyridine Moiety ◽  
New Compounds

( E)-4-[2-(Pyridin-4-yl)vinyl]benzaldehyde, containing both a 4-vinylpyridine and an aldehyde functionality, is utilized to develop new, highly conjugated chalcone compounds and a bis-Schiff base azine compound. The chalcone-containing compounds are further explored for their protonation, methylation and silver(I) coordination chemistry using the pyridine moiety. In parallel, a cyano-containing analogue, ( E)-4-[2-(pyridin-4-yl)vinyl]benzonitrile is also synthesized and studied for its silver(I) coordination chemistry. These new compounds are fully characterized by mass spectrometry, elemental analysis and spectroscopic techniques. The methylated product of ( E)-1-(9-anthryl)-3-{4-[2-(pyridin-4-yl)vinyl]phenyl}prop-2-en-1-one and a silver complex of ( E)-4-[2-(pyridin-4-yl)vinyl]benzonitrile are structurally determined by X-ray crystallography.

scholarly journals Isolation of a Novel Polyketide from Neodidymelliopsis sp.

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3235
Author(s):  
Melissa M. Cadelis ◽  
Hugo Gordon ◽  
Alex Grey ◽  
Soeren Geese ◽  
Daniel R. Mulholland ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Ambient Temperature ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Fungal Pathogens ◽  
Spectroscopic Techniques ◽  
Bioactive Natural Products

Fungi have become an invaluable source of bioactive natural products, with more than 5 million species of fungi spanning the globe. Fractionation of crude extract of Neodidymelliopsis sp., led to the isolation of a novel polyketide, (2Z)-cillifuranone (1) and five previously reported natural products, (2E)-cillifuranone (2), taiwapyrone (3), xylariolide D (4), pachybasin (5), and N-(5-hydroxypentyl)acetamide (6). It was discovered that (2Z)-cillifuranone (1) was particularly sensitive to ambient temperature and light resulting in isomerisation to (2E)-cillifuranone (2). Structure elucidation of all the natural products were conducted by NMR spectroscopic techniques. The antimicrobial activity of 2, 3, and 5 were evaluated against a variety of bacterial and fungal pathogens. A sodium [1-13C] acetate labelling study was conducted on Neodidymelliopsis sp. and confirmed that pachybasin is biosynthesised through the acetate polyketide pathway.

scholarly journals Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium, Streptomyces sp. SV 21

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 81
Author(s):  
Joko T. Wibowo ◽  
Matthias Y. Kellermann ◽  
Matthias Köck ◽  
Masteria Y. Putra ◽  
Tutik Murniasih ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Structure Elucidation ◽  
Nmr Spectra ◽  
Sea Cucumber ◽  
Spectroscopic Techniques ◽  
Drug Resistant ◽  
Molecular Fragments ◽  
1H And 13C Nmr ◽  
Positive Strain ◽  
Infective Potential

The manuscript investigated the isolation, characterization and anti-infective potential of valinomycin (3), streptodepsipeptide P11A (2), streptodepsipeptide P11B (1), and one novel valinomycin analogue, streptodepsipeptide SV21 (4), which were all produced by the Gram-positive strain Streptomycescavourensis SV 21. Although the exact molecular weight and major molecular fragments were recently reported for compound 4, its structure elucidation was not based on compound isolation and spectroscopic techniques. We successfully isolated and elucidated the structure based on the MS2 fragmentation pathways as well as 1H and 13C NMR spectra and found that the previously reported structure of compound 4 differs from our analysis. Our findings showed the importance of isolation and structure elucidation of bacterial compounds in the era of fast omics technologies. The here performed anti-infective assays showed moderate to potent activity against fungi, multi drug resistant (MDR) bacteria and infectivity of the Hepatitis C Virus (HCV). While compounds 2, 3 and 4 revealed potent antiviral activity, the observed minor cytotoxicity needs further investigation. Furthermore, the here performed anti-infective assays disclosed that the symmetry of the valinomycin molecule is most important for its bioactivity, a fact that has not been reported so far.

Two Ceramides from Tanacetum artemesioides

2004 ◽  
Vol 59 (3) ◽  
pp. 329-333 ◽  
Author(s):  
Viqar U. Ahmad ◽  
Javid Hussain ◽  
Hidayat Hussain ◽  
Umar Farooq ◽  
Erum Akber ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Nmr Analysis ◽  
New Compounds

Two new ceramides have been isolated from Tanacetum artemisioides, besides the known constituents β -sitosterol and β -sitosterol glycoside. The structure elucidation of the isolated new compounds was based primarily on 1D and 2D NMR analysis, including COSY, HMQC, HMBC correlations. The compound 1 and 2 showed inhibitory activity against acetylcholinesterase

New compounds of the manumycin group of antibiotics and a facilitated route for their structure elucidation

1993 ◽  
Vol 58 (24) ◽  
pp. 6583-6587 ◽  
Author(s):  
Isabel Sattler ◽  
Christine Groene ◽  
Axel Zeeck
Keyword(s):  
Structure Elucidation ◽  
New Compounds

scholarly journals Synthesis, Characterization and Biological Activity Study of New Compounds Tetrazole Derivatives Azo-Schiff Base

2019 ◽  
Vol 25 (103) ◽  
pp. 68-89
Author(s):  
Hiba Ibrahim Abdulla AL-Joubory ◽  
Khalid Mohamad Motny Al-janaby
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Pathogenic Bacteria ◽  
Diazonium Salt ◽  
Aldehyde Group ◽  
Spectroscopic Techniques ◽  
Phenyl Hydrazine ◽  
Ft Ir ◽  
New Compounds ◽  
Tetrazole Derivatives

This work included synthesis of azo dye (H1) by the reaction of diazonium salt to sulfacetamide with 4-hydroxy benzaldehyde at (0-5) oC  and synthesis of schiff base (H2-H6) through reaction substituted aromatic amine (aniline, 4-nitro aniline, 4-chloro aniline, 4-amino benzoic acid and phenyl hydrazine)  with aldehyde group in azo compound (H1) in ethanol compounds (H2-H6) and tetrazole derivatives prepared by reaction schiff base with sodium azide in ethanol compounds (H7-H11) and characterization by using spectroscopic techniques Uv/Vis, FT-IR, C.H.N. and H1-NMR of some the prepared compounds using DMSO-d6 a solvent, in addition melting point and determination a purity of TLC, and this work consists a study of biological activity for the some prepared compounds against four types of pathogenic bacteria and know to be resistant to anti biotic.

scholarly journals Purification, Characterization, and Antioxidant Activity of Daucosterol and Stigmasterol from Prangos ferulacea

2020 ◽  
Vol 10 (2) ◽  
pp. 2174-2180
Keyword(s):  
Antioxidant Activity ◽  
Structure Elucidation ◽  
Antiradical Activity ◽  
Bioactive Metabolites ◽  
Spectroscopic Techniques ◽  
Chromatographic Techniques ◽  
Phytochemical Investigation ◽  
Antioxidant Agents ◽  
Wide Range ◽  
Ft Ir

The genus Prangos is traditionally used for medicinal and food purposes. This genus contains a wide range of bioactive metabolites. In this work, phytochemical investigation and antioxidant activity evaluation of Prangos ferulacea were carried out. Chromatographic techniques were employed for the purification of extracts components. Spectroscopic techniques such as NMR, FT-IR, together with elemental analysis, were used for the structure elucidation of isolated compounds. Stigmasterol, daucosterol, and salicylic acid were purified and identified. Isolated compounds showed moderate to high antiradical activity in DPPH antioxidant assay. Results indicated the potential of P. ferulacea as a source of steroid and their glycosides and also its possible applications as antioxidant agents.

Chemical investigation on the root bark of Bombax malabarica

Fitoterapia ◽  
2019 ◽  
Vol 139 ◽  
pp. 104376
Author(s):  
Sio-Hong Lam ◽  
Jhong-Min Chen ◽  
Sheng-Fa Tsai ◽  
Shoei-Sheng Lee
Keyword(s):  
Chemical Investigation ◽  
Root Bark

scholarly journals Two New Compounds from Artemisia sacrorum

2016 ◽  
Vol 11 (4) ◽  
pp. 1934578X1601100
Author(s):  
Qinghu Wang ◽  
Rongjun Wu ◽  
Narenchaoketu Han ◽  
Nayintai Dai ◽  
Jiesi Wu
Keyword(s):  
Structure Elucidation ◽  
2D Nmr ◽  
Etoac Extract ◽  
First Report ◽  
Esi Ms ◽  
New Compounds

Two new compounds, named as sacric acid A (1) and sacric acid B (2), were isolated from the EtOAc extract of Artemisia sacrorum Ledeb. This is the first report on the structure elucidation of these compounds based on UV, IR, and extensive 1D and 2D NMR spectroscopic, and ESI-MS techniques.

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