scholarly journals Zinc Deficiency and Intestinal Permeability in the Context of Rational Diagnostic and Drug Development for Diarrhea-Predominant Irritable Bowel Syndrome

2022 ◽  
Author(s):  
Eric D. Shah
Keyword(s):  
Irritable Bowel Syndrome ◽  
Drug Development ◽  
Intestinal Permeability ◽  
Zinc Deficiency ◽  
Irritable Bowel

scholarly journals Tong-Xie-Yao-Fang improves intestinal permeability in diarrhoea-predominant irritable bowel syndrome rats by inhibiting the NF-κB and notch signalling pathways

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Qiuke Hou ◽  
Yongquan Huang ◽  
Zhaoyang Zhu ◽  
Liu Liao ◽  
Xinlin Chen ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Permeability ◽  
Rat Model ◽  
Distal Colon ◽  
Notch Signalling ◽  
Signalling Pathways ◽  
Model Group ◽  
Related Factors ◽  
Defecation Frequency ◽  
Irritable Bowel

Abstract Background Tong-Xie-Yao-Fang (TXYF) has been shown to be effective in diarrhoea-predominant irritable bowel syndrome (IBS-D) patients. However, the underlying mechanism remains to be clarified. The aim of this study was to investigate the efficacy and related mechanisms of TXYF in an IBS-D rat model. Methods The IBS-D rat model was established with 4% acetic acid and evaluated by haematoxylin-eosin (HE) staining. Then, IBS-D rats were divided into control, TXYF and rifaximin groups and treated intragastrically with normal saline, TXYF and rifaximin, respectively, for 14 days. The following indicators were measured before and after treatment: defecation frequency, faecal water content (FWC) and colorectal distension (CRD). Histopathological changes in the distal colon were observed after treatment. The expression of OCLN and ZO1 in the distal colon of IBS-D rats reflected the intestinal mucosal permeability, as measured by qRT-PCR, western blot, and enzyme-linked immunosorbent assays (ELISAs). The NF-κB and Notch signalling pathways and inflammation-related factors were investigated. Results After treatment with TXYF, the defecation frequency, FWC and CRD were significantly lower than those in the model group (P < 0.05). HE staining showed that colonic epithelial cells (CECs) in the IBS-D rats displayed significant oedema, impaired intestinal mucosal integrity and an increased influx of inflammatory cells. A significant reduction in granulocyte and CEC oedema was observed after the administration of TXYF and rifaximin compared to that of the model group and blank group (P < 0.05). TXYF significantly upregulated the expression of OCLN and ZO-1 and downregulated inflammation-related factors (IL-6, IL-1β, and TNF-α and the chemokine KC) in IBS-D rats compared to those in the model group rats (P < 0.05). In terms of the NF-κB and Notch signalling pathways, the expression of NICD, p-ERK, Hes-1 and p-P65 decreased significantly in the TXYF and rifaximin groups, while the expression of ATOH1 increased significantly compared to that in the model group (P < 0.05). Conclusion TXYF can effectively improve intestinal permeability and enhance intestinal mucosal barrier function, which may be related to inhibition of the inflammatory cascade and the NF-κB and Notch signalling pathways.

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

2012 ◽  
Vol 36 (11-12) ◽  
pp. 1009-1031 ◽  
Author(s):  
J. Matricon ◽  
M. Meleine ◽  
A. Gelot ◽  
T. Piche ◽  
M. Dapoigny ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Permeability ◽  
Immune Activation ◽  
Review Article ◽  
Irritable Bowel

scholarly journals Mucosal Mast Cell Count Is Associated With Intestinal Permeability in Patients With Diarrhea Predominant Irritable Bowel Syndrome

2013 ◽  
Vol 19 (2) ◽  
pp. 244-250 ◽  
Author(s):  
Hyuk Lee ◽  
Jung Ho Park ◽  
Dong Il Park ◽  
Hong Joo Kim ◽  
Yong Kyun Cho ◽  
...  
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Cell Count ◽  
Intestinal Permeability ◽  
Mucosal Mast Cell ◽  
Mast Cell Count ◽  
Irritable Bowel

Intestinal Permeability in Irritable Bowel Syndrome Patients: Effects of NSAIDs

2009 ◽  
Vol 55 (3) ◽  
pp. 716-723 ◽  
Author(s):  
Angèle P. M. Kerckhoffs ◽  
Louis M. A. Akkermans ◽  
Martin B. M. de Smet ◽  
Marc G. H. Besselink ◽  
Falco Hietbrink ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Permeability ◽  
Irritable Bowel

Intestinal permeability is increased in children with irritable bowel syndrome: A case–control study

2017 ◽  
Vol 49 (4) ◽  
pp. e274-e275
Author(s):  
V. Giorgio ◽  
C. Russo ◽  
S. Filoni ◽  
F. Lecci ◽  
G. Giarrusso ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Permeability ◽  
Case Control Study ◽  
Case Control ◽  
Irritable Bowel ◽  
Control Study
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