scholarly journals Correlations among metamorphopsia test scores, optical coherence tomography findings and multifocal electroretinogram responses in epiretinal membrane patients

2021 ◽  
Author(s):  
Jung Woo Lee ◽  
Sung Yong Park ◽  
Patrick S. Kim ◽  
In Hwan Cho ◽  
Hoon Dong Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Test Scores ◽  
Epiretinal Membrane ◽  
Retinal Thickness ◽  
Multifocal Electroretinogram ◽  
Optical Coherence ◽  
Topographic Map ◽  
Corrected Visual Acuity ◽  
The Mean ◽  
The Individual

Abstract Purpose To quantify metamorphopsia with a novel objective method in patients with epiretinal membrane (ERM) and to compare the relationships among metamorphopsia scores, spectral-domain optical coherence tomography (OCT) findings, and multifocal electroretinogram (mfERG) results. Methods This study included 52 eyes of 52 patients with idiopathic ERM who underwent comprehensive ophthalmologic examinations, including measurement of best-corrected visual acuity (BCVA), OCT, and mfERG. The degree of metamorphopsia was quantified using MonPack One® (Metrovision, Perenchies, France). On the topographic map of the early treatment diabetic retinopathy (ETDRS) grid, retinal thickness in the central, superior, inferior, nasal, and temporal subfields were measured, and metamorphopsia scores for each corresponding subfield were also obtained. The amplitudes and implicit times of mERG were elicited from each subfield. Then, the correlations among metamorphopsia scores, OCT findings, and mfERG responses were analyzed. Results The mean age of the patients was 65.3 ± 18.5 y, and the average metamorphopsia score of the individual subfields was 2.03 ± 1.18. Initial BCVA was 0.50 ± 0.12 logMAR, but there was no significant correlation between metamorphopsia scores and BCVA. The metamorphopsia scores from the central subfields showed significant correlations with central retinal thickness (CRT) (p = 0.001). The mean metamorphopsia scores in the central subfield showed a significant relationship with the mean N1 and P1 amplitudes (p = 0.001, p = 0.048, respectively), while no relationship was observed between metamorphopsia scores and mfERG amplitudes in other subfields. Conclusions The degree of metamorphopsia in patients with ERM could be objectively quantified in each subfield using a novel metamorphopsia test. The metamorphopsia scores were significantly correlated with retinal thickness, especially at the central subfields, and the scores in the central subfields were significantly correlated with the N1 and P1 amplitudes of mfERG. Thus, the metamorphopsia test can be a useful method to evaluate metamorphopsia symptoms for patients with ERM.

Optical coherence tomography biomarkers for visual acuity in patients with idiopathic epiretinal membrane

2020 ◽  
pp. 112067212098095
Author(s):  
Evdoxia-Maria Karasavvidou ◽  
Georgios D Panos ◽  
Spyridon Koronis ◽  
Vassilios P Kozobolis ◽  
Paris G Tranos
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Epiretinal Membrane ◽  
Retinal Thickness ◽  
Segment Length ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Foveal Thickness ◽  
Cotton Ball ◽  
Idiopathic Epiretinal Membrane

Purpose: To investigate the correlation between outer and inner retina optical coherence tomography (OCT) biomarkers and visual acuity in patients with idiopathic epiretinal membrane (iERM) and identify which of them may be predictive of visual function. Methods: A retrospective cross-sectional single-center study was conducted that included patients diagnosed with iERM. Spectral domain OCT images were obtained and assessed qualitatively and quantitatively. The association of OCT parameters with best corrected visual acuity was analyzed. Results: Charts of 97 eyes of 97 patients were reviewed. Central foveal thickness, maximal retinal thickness (MRT), photoreceptor outer segment length, outer foveal thickness, ganglion cell-inner plexiform layer complex thickening, inner retinal thickness and inner retinal layer irregularity index were among the major outcome measures. OCT scans were also assessed for the presence of cotton ball sign, ellipsoid zone disruption, ectopic inner foveal layer, disorganization of retinal inner layers (DRIL), intraretinal fluid, subretinal fluid (SRF) and epimacular membrane rip. Univariate analysis showed statistically significant association between all the aforementioned parameters with worse vision, except for cotton ball sign and SRF. Multivariate analysis found that MRT and severe DRIL were strongly correlated with worse vision ( p < 0.001). Conclusion: MRT and severe DRIL should be considered as negative prognostic factors for visual acuity.

scholarly journals Cone Dystrophies: An Optical Coherence Tomography Angiography Study

2020 ◽  
Vol 9 (5) ◽  
pp. 1500
Author(s):  
Lisa Toto ◽  
Maurizio Battaglia Parodi ◽  
Rossella D’Aloisio ◽  
Stefano Mercuri ◽  
Alfonso Senatore ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Thickness ◽  
Multifocal Electroretinogram ◽  
Vessel Density ◽  
Field Pattern ◽  
Ophthalmological Examination ◽  
Optical Coherence ◽  
Macular Function ◽  
Capillary Plexus

Background: This study investigates the relationship between retinal vascularization and macular function in patients with cone dystrophies (CDs). Methods: Twenty CD patients (40 eyes) and 20 healthy controls (20 eyes) were enrolled in this prospective case-control study. Patients underwent full ophthalmological examination, microperimetry, full-field, pattern and multifocal electroretinogram (ERG, PERG, mfERG) and optical coherence tomography angiography (OCTA). Main outcome measures were as follows: foveal and parafoveal inner and outer retinal thickness; microperimetry sensitivity in the central 4° and 8°, ERG b wave amplitudes and peak times, PERG P50 and N95 amplitudes and latencies, and mfERG N1 to P1 amplitudes; and superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillary (CC) plexus vessel densities, divided into foveal and parafoveal region. Results: Retinal thickness, SCP and DCP densities were significantly related to PERG. A significant relationship was found between foveal and parafoveal retinal thicknesses and foveal SCP density (p < 0.001 and p = 0.018, respectively) and between parafoveal retinal thickness and parafoveal SCP density (p = 0.002). Foveal and parafoveal retinal thicknesses were significantly related to parafoveal DCP density (p = 0.007 and p < 0.001). Foveal and parafoveal retinal thicknesses, foveal SCP and parafoveal DPC densities were significantly reduced in CD patients compared to controls (p < 0.001; p = 0.010 and p = 0.008, respectively). PERG and mfERG amplitudes were significantly reduced in CD patients compared to controls (p < 0.01). Conclusions: CD eyes showed reduced retinal thickness significantly related to reduced vessel density, possibly caused by a decreased metabolic demand. In addition, vessel density significantly correlated with loss of function.

scholarly journals X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Qin-rui Hu ◽  
Lv-zhen Huang ◽  
Xiao-li Chen ◽  
Hui-ka Xia ◽  
Tian-qi Li ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Thickness ◽  
Optical Coherence ◽  
Clinical Protocol ◽  
Juvenile Period ◽  
Corrected Visual Acuity ◽  
Structural Progression ◽  
One Year ◽  
Sd Oct

Purpose.To explore the structural progression of X-linked retinoschisis (XLRS) in patients by using spectral-domain optical coherence tomography (SD-OCT).Design.Retrospective, observational study.Methods.Patients who were diagnosed with XLRS by genetic testing underwent comprehensive ophthalmological examinations from December 2014 to October 2016. Each eye was measured by SD-OCT using the same clinical protocol. A correlation between best-corrected visual acuity (VA) and SD-OCT measurements was observed.Results.Six patients demonstrated retinoschisis (12 eyes) and typical foveal cyst-like cavities (10 eyes) on SD-OCT images with a mean logMAR VA of 0.48. The median age was 7.5 years at the initial visit. Their foveal retinal thickness (516.9 μm) and choroid thickness (351.4 μm) decreased at a rate of 38.1 and 7.5 μm, respectively, at the 10.5-month follow-up visit; however, there were no significant differences (P=0.622andP=0.406, resp.). There was no significant correlation between VA, the foveal retinal thickness, and subfoveal choroid thickness.Conclusions.SD-OCT images for XLRS patients during the juvenile period revealed no significant changes in the fundus structure, including the foveal retinal thickness and choroid thickness within one-year follow-up. There was a lack of correlation between VA, foveal retinal thickness, and subfoveal choroid thickness.

scholarly journals Visualization of microaneurysms in macular telangiectasia type 1 on optical coherence tomography angiography before and after photocoagulation

2020 ◽  
Author(s):  
Mitsuko Nakai ◽  
Hisashi Iwami ◽  
Hisashi Fukuyama ◽  
Fumi Gomi
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Cystoid Macular Edema ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Thickness ◽  
Optical Coherence ◽  
Macular Telangiectasia ◽  
Corrected Visual Acuity ◽  
Before And After

Abstract Purpose To evaluate changes in the visualization of microaneurysms (MAs) in cases of macular telangiectasia (Mac Tel) type 1 on optical coherence tomography angiography (OCTA) before and after treatment with direct photocoagulation and to evaluate their relationship with treatment efficacy. Methods The study included 12 eyes from 12 patients (8 men, 4 women; mean age 72.1 years) with Mac Tel type 1 accompanied by cystoid macular edema. OCTA for the evaluation of MAs was performed before and 15 min and 6, 12, and 24 weeks after photocoagulation. The best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were also evaluated. Results A total of 73 MAs were detected within the areas of macular edema on OCTA, and 39 of these underwent photocoagulation. At 15 min after treatment, 17 MAs were no longer visible on OCTA. At 6 weeks, two MAs had reappeared, whereas five additional MAs were no longer visible. The CRT in eyes with resolved MA was significantly less than that in eyes with persistent MAs (p = 0.016). At 24 weeks, seven eyes had no visible MAs, and the BCVA was not significantly different from baseline. Conclusion OCTA can monitor changes in the visualization of MAs associated with Mac Tel type 1 after direct photocoagulation. Eyes in which MAs disappeared after treatment could recover from cystoid macular edema.

scholarly journals Structural and functional macular changes after cataract surgery in diabetic patients

2020 ◽  
Vol 73 (9-10) ◽  
pp. 284-290
Author(s):  
Sasa Smoljanovic-Skocic ◽  
Bojana Markic ◽  
Sanela-Sanja Burgic ◽  
Milka Mavija ◽  
Stefan Brunet
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Cataract Surgery ◽  
Retinal Thickness ◽  
Central Retinal Thickness ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Corrected Visual Acuity ◽  
Group I ◽  
Best Corrected Visual Acuity

Introduction. In recent years, the number of diabetic patients requiring cataract surgery has been on the rise. The aim of this study was to examine the effects of cataract surgery on visual acuity and changes in the central retinal thickness in diabetic patients with and without retinopathy, in relation to the duration of the disease, type of therapy, and the level of glycated hemoglobin and serum lipids. Material and Methods. The prospective study included 51 eyes of 34 patients divided into three groups. Preoperatively, all patients underwent best-corrected visual acuity evaluation with Snellen chart, cataract grading using lens opacities classification system III, as well as fundus examination and optical coherence tomography. Postoperative follow-up visits were scheduled after the first, fourth, sixth, eighth, and twelfth weeks after which the patients underwent best-corrected visual acuity evaluation and optical coherence tomography. The obtained values were statistically processed and analyzed in relation to the duration of the disease, the type of therapy, and the level of glycated hemoglobin and serum lipids. Results. Of 51 eyes, 5.9% developed macular edema during the fourth postoperative week with central retinal thickness > 310 ?m. Subclinical central retinal thickness changes were registered in all groups with the highest values in group I (diabetics with retinopathy) in the sixth postoperative week. The average value of central retinal thickness in group I was 256 ? 11 ?m at baseline and 273 ? 11 ?m in week 6. The best-corrected visual acuity improved in all groups, without changes in central retinal thickness. Conclusion. Good visual acuity and absence of significant changes in macular thickness are helpful when making the decision to perform cataract surgery in patients with diabetes. Postoperative follow-up visits should include optical coherence tomography in addition to standard procedures.

scholarly journals Macular Thickness Assessed with Optical Coherence Tomography in Young Chinese Myopic Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Minghui Zhao ◽  
Qiang Wu ◽  
Ping Hu ◽  
Lili Jia
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Negative Correlation ◽  
Retinal Thickness ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Foveal Thickness ◽  
Positive Correlation ◽  
Central Foveal Thickness ◽  
The Mean

Purpose.To evaluate the variations in macular thickness in young Chinese myopic persons and the association with axial length (AL), spherical equivalence refraction (SE), age, intraocular pressure, and sex.Methods.In total, 133 young Chinese myopic subjects between 18 and 30 years of age were selected. The macular thickness was assessed using third-generation optical coherence tomography. AL, intraocular pressure, and SE were also measured.Results.The mean central foveal thickness was191.1±15.3 µm. The macula was consistently thinner in women than in men. Central foveal thickness had a significant positive correlation with AL and a negative correlation with SE. In the inner and outer regions, the macular thickness had a positive correlation with SE and negative correlation with AL.Conclusions.The retina was thinner in women than in men. Associated with myopic progression and AL extension, the central foveal thickness increased, while the retinal thickness of the inner and outer regions decreased.

scholarly journals Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

Tomography ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 189-199
Author(s):  
Klaudia Ulfik-Dembska ◽  
Sławomir Teper ◽  
Michał Dembski ◽  
Anna Nowińska ◽  
Edward Wylęgała
Keyword(s):  
Optical Coherence Tomography ◽  
Epiretinal Membrane ◽  
Retinal Thickness ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Foveal Thickness ◽  
Avascular Zone ◽  
Percentage Area ◽  
Retinal Structure ◽  
Support Decision Making

Background: The present study examined the relationships among macular microvasculature, retinal structure, and epiretinal membrane (ERM) and explored the utility of optical coherence tomography (OCT) angiography (OCTA) in idiopathic ERM assessment. Methods: The study sample comprised 276 eyes of 276 patients. A total of 154 eyes with ERM and 122 normal (control) eyes were analyzed. Only one eye of each participant was randomly selected for posterior segment imaging. Each patient underwent OCT and OCTA. Images were analyzed with AngioTool 0.6. Results: Foveal avascular zone was significantly smaller in the ERM group (p = 0.044). Average retinal thickness and foveal thickness were significantly higher in the ERM group (both p = 0.001). Moreover, 64 (41.5%) patients exhibited no metamorphopsia, while 46 (29.8%) and 44 (28.7%) patients exhibited moderate and extensive metamorphopsias, respectively. Meanwhile, FAZ was negatively correlated with central retinal thickness in the ERM group. The vessel area (p = 0.0017) and vessel percentage area (p = 0.044) were significantly greater in the ERM group. Conclusions: Changes observed in the superficial plexus in OCTA are related to the severity of metamorphopsia and can be further evaluated to support decision making regarding the surgical management of idiopathic ERM.

scholarly journals Precision and Agreement of Individual and Simultaneous Macular and Optic Disc Volumetric Measurements With Spectral Domain Optical Coherence Tomography

2021 ◽  
Vol 8 ◽  
Author(s):  
Alberto Domínguez-Vicent ◽  
Jesper Kensén ◽  
Marika Wahlberg Ramsay ◽  
Rune Brautaset ◽  
Abinaya Priya Venkataraman
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Optic Disc ◽  
Retinal Thickness ◽  
Ganglion Cell Complex ◽  
Optical Coherence ◽  
Limits Of Agreement ◽  
Repeatability Limit ◽  
The Individual ◽  
Scan Modes

Purpose: To evaluate the precision of individual and combined macula and optic disc volumetric analysis, and the agreement between these two scan modes with spectral domain optical coherence tomography (OCT).Methods: Macular and optic disc volumetric measurements were performed with individual and combined scan protocols in one eye of 75 healthy subjects. Three repeated measurements were performed with each protocol. From the macular area, retinal thickness in nine different sectors and ganglion cell complex thickness in eight different sectors were analyzed from both scan modes. From the optic disc area, the peripapillary retinal nerve fiber layer (pRNFL) thickness in 12 clock sectors and the optic disc parameters were evaluated. For all the parameters, repeatability limit and agreement analysis were performed.Results: For the retinal thickness measurements in macula, the combined scan had two to three times larger repeatability limit than the individual scan for all the sectors except the central sector, where the repeatability limit was five times larger. The limits of agreement intervals were lower than 20 μm for all sectors, except the central. The ganglion cell complex measurements also had larger repeatability limits for the combined scans, and the limits of agreement intervals were &lt;10 μm for all sectors. For the pRNFL thickness, the repeatability values were distributed like a vertically elongated ellipse for both scans, but still the repeatability was better for individual scan compared to the combined scan. The shortest and widest interval are obtained for sectors 9 (9 μm) and 12 (40 μm), respectively. The repeatability limit was &lt;0.15 units for all disc parameters with both scan modes.Conclusion: The individual macula and optic disc scans had better repeatability than the combined scan mode, and the two scan modes cannot be used interchangeability due to the wide limits of agreement.

scholarly journals Comparison of Macular Thickness in Diabetic Macular Edema Using Spectral-Domain Optical Coherence Tomography and Time-Domain Optical Coherence Tomography

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Masashi Kakinoki ◽  
Taichirou Miyake ◽  
Osamu Sawada ◽  
Tomoko Sawada ◽  
Hajime Kawamura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Time Domain ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Corrected Visual Acuity ◽  
The Mean ◽  
Sd Oct

Purpose. To compare the macular thicknesses in diabetic macular edema (DME) measured with spectral-domain optical coherence tomography (SD-OCT) and time-domain (TD) OCT.Patients and Methods.The average macular thicknesses of 50 eyes of 29 patients with DME were measured using SD-OCT and TD-OCT.Results.The mean macular thicknesses measured with TD-OCT and SD-OCT were401.5±117.8 μm (mean ± SD) and446.2±123.5 μm, respectively. The macular thicknesses measured with the two devices were well correlated (Pearson's product moment correlation,r=0.977,P<0.001). A significant correlation was found between the best-corrected visual acuity and the retinal thickness measured by TD-OCT and SD-OCT (Pearson's product moment correlation, TD-OCT,r=0.34;P<0.05; SD-OCT,r=0.32;P<0.05).Discussion.The mean macular thickness measured with SD-OCT was about 45 μm thicker than that measured with TD-OCT. Attention should be paid when comparing data obtained using different OCT machines.

Clinical and Optical Coherence Tomography Analysis of Intraretinal Microcysts in Patients with Epiretinal Membrane

2021 ◽  
pp. 1-7
Author(s):  
Mete Güler ◽  
Selma Urfalıoğlu ◽  
Elif Damar Güngör ◽  
Emine Atalay ◽  
Gökhan Köküsarı
Keyword(s):  
Optical Coherence Tomography ◽  
Epiretinal Membrane ◽  
Optical Coherence ◽  
Tomography Analysis
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