The negative effect of the PI3K inhibitor 3-methyladenine on planarian regeneration via the autophagy signalling pathway

Aromatase, the enzyme responsible for the transformation of androgens into oestrogens, is encoded by the cyp19 gene expressed in the testis. The aim of the present study was to analyse the evolution of aromatase gene expression under FSH control in rat Sertoli cells between 10 and 30 days post partum, corresponding to the end of the proliferative period of Sertoli cells, establishment of the blood–testis barrier and acquisition of the mature phenotype. The maximum stimulatory effect of FSH on aromatase gene expression was obtained in 20-day-old rat Sertoli cells, compared with cells from 10- and 30-day-old rats, in parallel with the differentiation of Sertoli cells. Using two effectors of the protein kinase A pathway (i.e. forskolin and dibutyryl-cAMP) revealed differential effects between cells from rats aged 20 and 30 days, implying the involvement of another signalling pathway. Experiments using the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 revealed that PI3-K is strongly involved in FSH-induced aromatase expression in Sertoli cells from both 20- and 30-day-old rats. In vivo, this decrease could be explained by a negative effect exerted by germ cells because, in coculture, aromatase gene expression in 20-day-old Sertoli cells is greatly diminished.

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189 Extracellular S100A1 protein modulates cardiac matrix gene expression through activation of the MAPK - NF-kappaB signalling pathway

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(07)60124-6 ◽

2007 ◽

Vol 6 (1) ◽

pp. 45-45

Author(s):

D ROHDE ◽

M BOERRIES ◽

S PLEGER ◽

P NAWROTH ◽

H KATUS ◽

...

Keyword(s):

Gene Expression ◽

Signalling Pathway ◽

Matrix Gene ◽

Nf Kappab

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Social Motives Predict Loneliness During a Developmental Transition

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000201 ◽

2017 ◽

Vol 76 (4) ◽

pp. 145-153 ◽

Cited By ~ 4

Author(s):

Jana Nikitin ◽

Alexandra M. Freund

Keyword(s):

Social Relationships ◽

Well Being ◽

Social Avoidance ◽

Social Approach ◽

Social Motives ◽

Developmental Transitions ◽

Avoidance Motivation ◽

Negative Effect ◽

Low Levels

Abstract. Establishing new social relationships is important for mastering developmental transitions in young adulthood. In a 2-year longitudinal study with four measurement occasions (T1: n = 245, T2: n = 96, T3: n = 103, T4: n = 85), we investigated the role of social motives in college students’ mastery of the transition of moving out of the parental home, using loneliness as an indicator of poor adjustment to the transition. Students with strong social approach motivation reported stable and low levels of loneliness. In contrast, students with strong social avoidance motivation reported high levels of loneliness. However, this effect dissipated relatively quickly as most of the young adults adapted to the transition over a period of several weeks. The present study also provides evidence for an interaction between social approach and social avoidance motives: Social approach motives buffered the negative effect on social well-being of social avoidance motives. These results illustrate the importance of social approach and social avoidance motives and their interplay during developmental transitions.

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A Longitudinal Study of Mental Health in Emerging Adults

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000132 ◽

2014 ◽

Vol 73 (3) ◽

pp. 135-141 ◽

Cited By ~ 1

Author(s):

Monica S. Bachmann ◽

Hansjörg Znoj ◽

Katja Haemmerli

Keyword(s):

Mental Health ◽

Longitudinal Study ◽

Emerging Adults ◽

Poor Mental Health ◽

Need Satisfaction ◽

Computer Assisted ◽

Consistency Model ◽

Negative Effect ◽

The Cross ◽

Health Model

Emerging adulthood is a time of instability. This longitudinal study investigated the relationship between mental health and need satisfaction among emerging adults over a period of five years and focused on gender-specific differences. Two possible causal models were examined: (1) the mental health model, which predicts that incongruence is due to the presence of impaired mental health at an earlier point in time; (2) the consistency model, which predicts that impaired mental health is due to a higher level of incongruence reported at an earlier point in time. Emerging adults (N = 1,017) aged 18–24 completed computer-assisted telephone interviews in 2003 (T1), 2005 (T2), and 2008 (T3). The results indicate that better mental health at T1 predicts a lower level of incongruence two years later (T2), when prior level of incongruence is controlled for. The same cross-lagged effect is shown for T3. However, the cross-lagged paths from incongruence to mental health are marginally associated when prior mental health is controlled for. No gender differences were found in the cross-lagged model. The results support the mental health model and show that incongruence does not have a long-lasting negative effect on mental health. The results highlight the importance of identifying emerging adults with poor mental health early to provide support regarding need satisfaction.

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Working Memory, Mental Prospection, Time Orientation, and Cognitive Insight

Journal of Individual Differences ◽

10.1027/1614-0001/a000111 ◽

2013 ◽

Vol 34 (3) ◽

pp. 159-169 ◽

Cited By ~ 4

Author(s):

Sevtap Cinan ◽

Aslı Doğan

Keyword(s):

Working Memory ◽

Structural Equation ◽

Factor Model ◽

Time Orientation ◽

Equation Modeling ◽

Cognitive Insight ◽

Confirmatory Factor ◽

Negative Effect ◽

Positive Effect ◽

Three Factor

This research is new in its attempt to take future time orientation, morningness orientation, and prospective memory as measures of mental prospection, and to examine a three-factor model that assumes working memory, mental prospection, and cognitive insight are independent but related higher-order cognitive constructs by using confirmatory factor analysis (CFA). The three-factor model produced a good fit to the data. An alternative one-factor model was tested and rejected. The results suggest that working memory and cognitive insight are distinguishable, related constructs, and that both are distinct from, but negatively associated with, mental prospection. In addition, structural equation modeling (SEM) showed that working memory had a strong positive effect on cognitive insight and a moderate negative effect on mental prospection.

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