Human health risk assessment related to contaminated land: state of the art

2015 ◽  
Vol 37 (4) ◽  
pp. 651-673 ◽  
Author(s):  
F. A. Swartjes
2008 ◽  
Vol 24 (suppl 4) ◽  
pp. a569-s580 ◽  
Author(s):  
Sérgio Silveira Franco ◽  
Adelaide Cássia Nardocci ◽  
Wanda Maria Risso Günther

Polycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers for human health risk assessment and also discusses their applicability within the context of environmental management in Brazil. The article discusses the methodologies for determination of some biomarkers such as 1-hydroxypyrene and PAH-DNA adducts. Cytogenetic markers, frequency of chromosomal aberrations, and micronucleus induction were considered for the evaluation of cancer risk. The current stage of studies on validation of such biomarkers was also approached.


2006 ◽  
Vol 14 (2) ◽  
pp. 559-570 ◽  
Author(s):  
F. Quercia ◽  
A. Vecchio ◽  
M. Falconi ◽  
L. Togni ◽  
E. Wcislo ◽  
...  

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