Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study

Background: The study aims to examine the association between lifestyle habits and breast cancer risk in a Moroccan population.Methods: This is a case-control study conducted at the Mohammed VI Centre for cancer treatment in Casablanca.Results: The results highlighted that family history of breast cancer (OR=5.73) and alcohol consumption (OR=3.76) were positively associated with breast cancer. Analysis of anthropometric parameters showed that the risk of developing breast cancer is estimated at 1.78 in overweight women and 2.39 in obese women compared to those of normal weight. The risk of developing breast cancer is estimated at 1.82 for women with a WC greater than 88 cm and 1.70 for women with a WHR greater than 0.85. At age 10, the risk is 1.60 for women with a large figure compared to women with a small figure. However, at age 40, the average body shape relative to the lean body was associated with a decreased risk of breast cancer. In addition, the data confirmed that physical activity participation decreases with age; in childhood and adolescence, women are more active while in post-menopause, women become moderately active. Being very active in childhood, peri-menopause and post-menopause seems to be a protective factor against the occurrence of breast cancer.Conclusions: The study showed that the risk of breast cancer is potentially high in elderly women, overweight women and women with a family history of cancer. This risk was increased by behavioral factors such as toxic habits and physical inactivity.

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Family history of breast cancer in non-BRCA male breast cancer: A case-control study.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e13032 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e13032-e13032

Author(s):

Gregory Sampang Calip ◽

Katherine Rebecca Exten ◽

Garth H Rauscher ◽

Krystal Brown ◽

Ryan Bernhisel ◽

...

Keyword(s):

Breast Cancer ◽

Family History ◽

Cancer Risk ◽

Case Control Study ◽

Brca Mutation ◽

Case Control ◽

Cancer Risk Counseling ◽

Mmr Genes ◽

History Of ◽

Control Study

e13032 Background: Approximately 85% of male breast cancer (MBC) patients test negative for a BRCA mutation, and the role of genetic predisposition is unclear. Cancer risk counseling for unaffected relatives of BRCA-negative MBC patients relies on accurate cancer risk estimates, but there is limited data on the risk of breast cancer (BC) for relatives of these men. We characterized the association between MBC and family history of BC in patients who test negative for BRCA mutations in order to facilitate cancer risk counseling and to explore the possibility of unidentified MBC susceptibility alleles. Methods: We performed a case-control study of patients who had full length sequencing and large-rearrangement analysis for germline mutations in BRCA1/2 or the mismatch repair (MMR) genes at a commercial laboratory from 2006-2012. Cases were MBC patients who tested negative for a BRCA1/2 mutation (n = 3,647); controls were male colon cancer patients who tested negative for mutations in MMR genes (n = 4,269). Information on family history of BC was ascertained from test request forms completed by the ordering healthcare provider at the time of testing. Unconditional multivariable logistic regression models estimated odds ratios (OR) and 95% confidence intervals (CI) for associations between family history of BC in first- (FDR) and second-degree relatives (SDR) and MBC with adjustment for potential confounders (age, ethnicity, year of testing). Results: Compared to controls, MBC cases had higher odds of BC in a FDR or SDR (OR = 4.7; 95% CI 4.1, 5.3). Associations were strongest for family history of BC in 1 female FDR (OR = 3.9; 95% CI: 3.3, 4.6), ≥2 female FDR (OR = 7.5; 95% CI 5.0, 11.4), BC in a FDR < 45 years old (for cases diagnosed < 45, OR = 6.9; 95% CI 3.9, 12.4), a male FDR or SDR with BC (OR = 17.9; 95% CI 7.6, 42.1), and both a male and female FDR or SDR with BC (OR = 15.7; 95%CI 4.4, 55.3). Conclusions: MBC patients who test negative for a BRCA mutation have significantly higher odds of reporting family members affected by breast cancer, particularly with affected FDR < 45 years old, multiple affected relatives, and male relatives with BC. This data can guide risk counseling in MBC families, and suggests the existence of unidentified MBC susceptibility alleles.

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Breast Cancer Risk Factors in Italian Women: A Multicentric Case-Control Study

Tumori Journal ◽

10.1177/030089168607200304 ◽

1986 ◽

Vol 72 (3) ◽

pp. 241-249 ◽

Cited By ~ 26

Author(s):

Antonio Toti ◽

Silvio Agugiaro ◽

Dino Amadori ◽

Gianfranco Buzzi ◽

Paolo Bruzzi ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Family History ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Case Control ◽

Female Population ◽

History Of ◽

Control Study

To evaluate the importance of several risk factors for breast cancer in the Italian female population, a large multicentric case-control study was conducted in 10 breast clinics in Italy. The study included 1,556 women affected by breast cancer, histologically and/or cytologically confirmed. Controls were 1,505 women admitted to a hospital in the same town, matched with cases for residence and with the same age distribution of the Italian female population. The risk factors considered in this study were family history of breast cancer, reproductive history, height and weight, use of oral contraceptives, other hormonal therapies and smoking history. The results of this study confirm the significant role of a positive family history of breast cancer (RR = 2.37); the relative risk was even higher when a first-degree relative was affected or the breast cancer was bilateral. The analysis of the reproductive history showed a significant trend of increasing risk with increasing age at first birth and, although less evident, with increasing number of children. Quetelet's index (kg/m–2) was positively correlated with breast cancer risk, mostly in postmenopausal women. Among other studied factors, only late age at menopause confirmed an increased risk for breast cancer, whereas age at menarche, use of oral contraceptives and smoking histories did not show any significant correlation with breast cancer risk. These results are in substantial agreement with other international studies, but represent an interesting contribution to studies about the Italian female population.

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Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study

BMC Cancer ◽

10.1186/1471-2407-14-662 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 6

Author(s):

Wenbin Zhou ◽

Qiang Ding ◽

Hong Pan ◽

Naping Wu ◽

Mengdi Liang ◽

...

Keyword(s):

Breast Cancer ◽

Family History ◽

Case Control Study ◽

Chinese Women ◽

Case Control ◽

First Degree Relatives ◽

History Of ◽

Control Study

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Misclassification Adjustment of Family History of Breast Cancer in a Case-Control Study: a Bayesian Approach

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2015.16.18.8221 ◽

2016 ◽

Vol 16 (18) ◽

pp. 8221-8226 ◽

Cited By ~ 5

Author(s):

Rahmatollah Moradzadeh ◽

Mohammad Ali Mansournia ◽

Taban Baghfalaki ◽

Reza Ghiasvand ◽

Mohammad Reza Noori-Daloii ◽

...

Keyword(s):

Breast Cancer ◽

Family History ◽

Bayesian Approach ◽

Case Control Study ◽

Case Control ◽

History Of ◽

Control Study

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Nutritional and environmental risk factors for breast cancer: a case-control study

Scientia Medica ◽

10.15448/1980-6108.2018.2.28723 ◽

2018 ◽

Vol 28 (2) ◽

pp. 28723 ◽

Cited By ~ 4

Author(s):

Sandra Azevedo Queiroz ◽

Iasmin Matias de Sousa ◽

Fernanda Rafaella de Melo Silva ◽

Clelia de Oliveira Lyra ◽

Ana Paula Trussardi Fayh

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Family History ◽

Case Control Study ◽

Case Control ◽

Case Group ◽

History Of ◽

Control Study ◽

History Of Cancer ◽

Overweight Or Obesity

AIMS: To investigate the associations between breast cancer diagnosis and nutritional and environmental factors in women from Northeast Brazil.METHODS: A case-control study included women evaluated in two hospitals specialized in cancer treatment. The case group was composed by women with breast cancer whose data were obtained during the hospitalization period for surgical treatment of the disease. The control group was selected in the same hospitals excluding the oncology ward. The following risk factors were investigated: household environmental sanitation, breastfeeding history, social class, smoking exposition, alcohol consumption and family history of cancer. A food frequency questionnaire was completed by the subjects and an evaluation of anthropometric nutritional status was made. Comparison for quantitative variables was performed using independent t-test or Mann-Whitney test. Chi-square or Fisher's exact test were used to compare categorical variables. The estimated risk associated with consumption of nutrients and food groups was assessed by OR, with a 95% confidence interval. In order to assess the effect of possible confounding factors such as excess weight or excessive caloric intake, a multivariate analysis was performed with the variables with p<0.15 in the food consumption analysis. The significance level for all analyses was set at p<0.05.RESULTS: The total sample consisted of 118 women, 59 in each group. Of all environmental risk factors investigated, poor sanitation (OR [odds ratio]=3.2, 95%CI 1.43-7.11) and family history for cancer (OR=3.11, 95%CI 1.42-6.78) were significantly associated with the diagnosis of breast cancer. Regarding anthropometric assessments, overweight or obesity and waist circumference >88cm were more prevalent in the case group (OR=2.70, 95%CI 1.28-5.70 and OR=3.10, 95%CI 1.46-6.56, respectively). Regular consumption of ultra-processed foods was identified as a risk factor for breast cancer (adjusted OR=2.35, 95%CI 1.08-5.12).CONCLUSIONS: Higher consumption of ultra-processed food, presence of overweight or obesity, waist circumference ≥88 cm, poor sanitation, and family history of cancer were risk factors for breast cancer in this sample of women living in Rio Grande do Norte state, Brazil.

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The association between diabetes and thyroid cancer risk: a hospital-based case-control study in China

BMC Endocrine Disorders ◽

10.1186/s12902-021-00684-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Meng Wang ◽

Wei-Wei Gong ◽

Feng Lu ◽

Ru-Ying Hu ◽

Qing-Fang He ◽

...

Keyword(s):

Thyroid Cancer ◽

Family History ◽

Case Control Study ◽

Positive Family History ◽

Case Control ◽

Diabetes Duration ◽

Family History Of Diabetes ◽

Thyroid Cancer Risk ◽

History Of ◽

Control Study

Abstract Background Previous studies have indicated inconsistent relationships of diabetes with thyroid cancer risk, yet little is known in China. In this study, we aimed to investigate the associations between diabetes, diabetes duration and the risk of thyroid cancer in Chinese population. Methods A 1:1 matched case-control study was performed between 2015 and 2017 in Zhejiang Province including 2,937 thyroid cancer cases and 2,937 healthy controls. Odds ratios (ORs) with 95 % confidence intervals (CIs) for thyroid cancer were estimated in logistic regression models. Specific effects stratified by age, as well as sex, body mass index (BMI) and family history of diabetes were also examined. Results Overall, neither diabetes (OR = 0.75, 95 % CI: 0.21–2.73) nor diabetes duration (OR = 0.14, 95 % CI: 0.02–1.22 for diabetes duration ≦ 5 years; OR = 2.10, 95 % CI: 0.32–13.94 for diabetes duration > 5 years) was significantly associated with thyroid cancer. In stratified analyses, significant lower risk of thyroid cancer was observed among subjects with diabetes and shorter diabetes duration ( ≦ 5 years), but limited to those who were aged more than 40 years, female, overweight/obese and had positive family history of diabetes. Conclusions Diabetes and shorter diabetes duration were significantly associated with decreased risk of thyroid cancer in individuals characterized by older age, female sex, higher BMI and positive family history of diabetes.

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Family history of hypertension increases risk of preeclampsia in pregnant women: a case-control study

Zinc supplementation improves heme biosynthesis in rats exposed to lead ◽

10.18051/univmed.2016.v35.181-191 ◽

2016 ◽

Vol 35 (3) ◽

pp. 181 ◽

Cited By ~ 1

Author(s):

Mulualem Endeshaw ◽

Fantu Abebe ◽

Melkamu Bedimo ◽

Anemaw Asrat ◽

Abebaw Gebeyehu ◽

...

Keyword(s):

Family History ◽

Pregnant Women ◽

Case Control Study ◽

Multiple Logistic Regression Analysis ◽

Multiple Pregnancy ◽

Case Control ◽

Outcome Variable ◽

History Of ◽

Family History Of Hypertension ◽

Control Study

Background Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortalities worldwide. Despite extensive research, the underlying cause of preeclampsia remains poorly understood. This study aimed to offer compelling evidence on the important risk factors of preeclampsia in Amhara region, Ethiopia. Methods A case control study was conducted in public health facilities of Bahir Dar city from September 2014 to January 2015. A total of 453 (151 cases and 302 controls) pregnant women were enrolled in this study. Hemoglobin level and urinary tract infection (UTI) status were collected from clinical notes. Oral examination was performed by a dentist for detection of periodontal diseases. Univariate and multiple logistic regression analysis was conducted to determine the relationship of all the independent variables with the outcome variable. A p-value <0.05 was declared statistically significant. Result Advanced maternal age (AOR=4.79;95% CI 1.031-22.18), family history of hypertension (AOR=11.16;95% CI 5.41-41.43), history of diabetes mellitus (AOR=6.17;95% CI 2.11-20.33), UTI in the current pregnancy (AOR=6.58;95% CI 2.93-14.73), failure to comply with iron and folic acid supplement during pregnancy (AOR=8.32;95% CI 3.35-20.62), lack of exercise (AOR=3.33;95% CI 1.35-8.17), multiple pregnancy (AOR=4.05;95% CI 1.57-12.27), anemia (AOR=4.19;95% CI 1.27-13.92), and periodontal disease or gingivitis (AOR =3.51;95% CI 1.14-10.83) were associated with preeclampsia. Conclusion Family history of hypertension was the most dominant risk factor for preeclampsia in pregnant women. Encouraging pregnant women to have health seeking behavior during pregnancy would provide a chance to diagnose preeclampsia as early as possible.

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