Family history of hypertension increases risk of  preeclampsia in pregnant women: a case-control study

Background Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortalities worldwide. Despite extensive research, the underlying cause of preeclampsia remains poorly understood. This study aimed to offer compelling evidence on the important risk factors of preeclampsia in Amhara region, Ethiopia. Methods A case control study was conducted in public health facilities of Bahir Dar city from September 2014 to January 2015. A total of 453 (151 cases and 302 controls) pregnant women were enrolled in this study. Hemoglobin level and urinary tract infection (UTI) status were collected from clinical notes. Oral examination was performed by a dentist for detection of periodontal diseases. Univariate and multiple logistic regression analysis was conducted to determine the relationship of all the independent variables with the outcome variable. A p-value <0.05 was declared statistically significant. Result Advanced maternal age (AOR=4.79;95% CI 1.031-22.18), family history of hypertension (AOR=11.16;95% CI 5.41-41.43), history of diabetes mellitus (AOR=6.17;95% CI 2.11-20.33), UTI in the current pregnancy (AOR=6.58;95% CI 2.93-14.73), failure to comply with iron and folic acid supplement during pregnancy (AOR=8.32;95% CI 3.35-20.62), lack of exercise (AOR=3.33;95% CI 1.35-8.17), multiple pregnancy (AOR=4.05;95% CI 1.57-12.27), anemia (AOR=4.19;95% CI 1.27-13.92), and periodontal disease or gingivitis (AOR =3.51;95% CI 1.14-10.83) were associated with preeclampsia. Conclusion Family history of hypertension was the most dominant risk factor for preeclampsia in pregnant women. Encouraging pregnant women to have health seeking behavior during pregnancy would provide a chance to diagnose preeclampsia as early as possible.

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Does anemia risk for pre-eclampsia? A multi-center, Case control study in Amhara region, Ethiopia.

10.21203/rs.2.14936/v1 ◽

2019 ◽

Author(s):

Almaz Aklilu Getu ◽

Gedefawe Abeje Fikadu ◽

Muluken Azage Yenesew ◽

Simegnew Asmer Getie

Keyword(s):

Family History ◽

Twin Pregnancy ◽

Case Control Study ◽

Case Control ◽

Referral Hospital ◽

Amhara Region ◽

Referral Hospitals ◽

History Of ◽

Family History Of Hypertension ◽

Control Study

Abstract Objective This study aimed to identify determinants of preeclampsia among women visiting referral hospitals in Amhara region. A hospital-based unmatched case-control study was conducted from February 20, 2016 to May 18, 2016 among 871 women visiting West Amhara referral hospital for prenatal care.Result Advanced age (>35 years) [AOR (95%CI), 3.09(1.80-3.35), being primigravidae [AOR (95%CI), 2.32 (1.61–3.35) family history of hypertension [AOR (95%CI), 4.31 (2.37–7.85)], twin pregnancy [AOR 95%CI, 3.53(1.77–7.06)], and Anemia [AOR (95%CI) = 1.49 (1.06– 2.1)] were determinants of preeclampsia.

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Determinants of Preeclampsia among Women Attending Delivery Services in Public Hospitals of Central Tigray, Northern Ethiopia: A Case-Control Study

Journal of Pregnancy ◽

10.1155/2021/4654828 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Teklehaimanot Gereziher Haile ◽

Nega Assefa ◽

Tadesse Alemayehu ◽

Teklewoini Mariye ◽

Gebreamlak Gebremedhn Geberemeskel ◽

...

Keyword(s):

Family History ◽

Case Control Study ◽

Vegetable Intake ◽

Case Control ◽

Public Hospitals ◽

Drinking Alcohol ◽

Delivery Services ◽

History Of ◽

Family History Of Hypertension ◽

Control Study

Background. Preeclampsia occurs in up to 5% of all pregnancies, in 10% of first pregnancies, and 20–25% of women with a history of chronic hypertension. Objective. This study aims to assess the determinants of preeclampsia among women attending delivery services in public hospitals of central Tigray, Ethiopia. Methods. Hospital-based unmatched case-control study design was conducted. Women diagnosed with preeclampsia were cases, and women who had no preeclampsia were controls admitted to the same hospitals. A systematic sampling technique was used to select study participants for both cases and controls. The data were entered in EPI data 3.1 statistical software and, then, exported to SPSS Version 22 for cleaning and analysis. Results. Family history of hypertension (AOR: 2.60; 95% CI: 1.15, 5.92), family history of preeclampsia (AOR: 5.24; 95% CI: 1.85, 14.80), history of diabetes mellitus (AOR: 4.31; 95% CI: 1.66, 11.21), anemia (AOR: 3.23; 95% CI: 1.18, 8.86), history of preeclampsia on prior pregnancy (AOR: 5.55; 95% CI: 1.80, 17.10), primigravida (AOR: 5.41; 95% CI: 2.85, 10.29), drinking alcohol during pregnancy (AOR: 4.06; 95% CI: 2.20, 7.52), and vegetable intake during pregnancy (AOR: 0.39; 95% CI: 0.21, 0.74) were significantly associated with preeclampsia. Conclusion. This study concludes that a family history of hypertension and preeclampsia; a history of diabetes mellitus and anemia; and a history of preeclampsia on prior pregnancy, primigravida, and drinking alcohol were found to be risk factors for preeclampsia. However, vegetable intake was found to be a protective factor for the development of preeclampsia.

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The association between diabetes and thyroid cancer risk: a hospital-based case-control study in China

BMC Endocrine Disorders ◽

10.1186/s12902-021-00684-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Meng Wang ◽

Wei-Wei Gong ◽

Feng Lu ◽

Ru-Ying Hu ◽

Qing-Fang He ◽

...

Keyword(s):

Thyroid Cancer ◽

Family History ◽

Case Control Study ◽

Positive Family History ◽

Case Control ◽

Diabetes Duration ◽

Family History Of Diabetes ◽

Thyroid Cancer Risk ◽

History Of ◽

Control Study

Abstract Background Previous studies have indicated inconsistent relationships of diabetes with thyroid cancer risk, yet little is known in China. In this study, we aimed to investigate the associations between diabetes, diabetes duration and the risk of thyroid cancer in Chinese population. Methods A 1:1 matched case-control study was performed between 2015 and 2017 in Zhejiang Province including 2,937 thyroid cancer cases and 2,937 healthy controls. Odds ratios (ORs) with 95 % confidence intervals (CIs) for thyroid cancer were estimated in logistic regression models. Specific effects stratified by age, as well as sex, body mass index (BMI) and family history of diabetes were also examined. Results Overall, neither diabetes (OR = 0.75, 95 % CI: 0.21–2.73) nor diabetes duration (OR = 0.14, 95 % CI: 0.02–1.22 for diabetes duration ≦ 5 years; OR = 2.10, 95 % CI: 0.32–13.94 for diabetes duration > 5 years) was significantly associated with thyroid cancer. In stratified analyses, significant lower risk of thyroid cancer was observed among subjects with diabetes and shorter diabetes duration ( ≦ 5 years), but limited to those who were aged more than 40 years, female, overweight/obese and had positive family history of diabetes. Conclusions Diabetes and shorter diabetes duration were significantly associated with decreased risk of thyroid cancer in individuals characterized by older age, female sex, higher BMI and positive family history of diabetes.

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Case control study to assess the determinants of pregnancy induced hypertension among the antenatal mothers in Rajiv Gandhi women and children hospital at Puducherry

Asian Pacific Journal of Nursing and Health Sciences ◽

10.46811/apjnh/3.2.2 ◽

2020 ◽

Vol 3 (2) ◽

pp. 9-14

Author(s):

Margaret A ◽

Manjubala Dash

Keyword(s):

Family History ◽

Case Control Study ◽

Pregnancy Induced Hypertension ◽

Family History Of Diabetes ◽

Induced Hypertension ◽

History Of ◽

Women And Children ◽

Family History Of Hypertension ◽

Pedal Edema ◽

Control Study

Background: Hypertensive disorders of pregnancy are a major health problem to the world and is found to be the major cause of maternal morbidity and mortality accounting for nearly 10-15% 0f maternal deaths. Objective:To assess the determinants of Pregnancy induced hypertension. Methods: A case control study was conducted among pregnant women at Rajiv Gandhi Women and Children Hospital, Puducherry. 63 women with PIH were selected as cases and 63 normotensive pregnant women were taken as controls. The cases were selected by purposive sampling and the controls by simple random sampling. The tool consists of a self structured questionnaire which consists of the socio demographic factors and various other determinants assumed as a risk factor for PIH and some required information was also obtained from the case records. Statistics: The odds ratio and Chi-square test was used to determine the risk and association between PIH and the determinants respectively.Results: Primigravida (OR=2.826), multiple pregnancy (OR=2.629), presence of pedal edema (OR=54.836), family history of diabetes (OR=2.969), family history of hypertension (OR=5.5) Overweight (OR=2.12) and obesity (OR=6.52) were found to be significant risk factors of PIH. There was statistically significant association with history of abortion, parity, presence of pedal edema, use of contraceptives, family history of diabetes, family history of hypertension, prepregnancy Body mass index and PIH.

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Relation of Family History of Cancer and Environmental Factors to the Risk of Colorectal Cancer: A Case-control Study

Japanese Journal of Clinical Oncology ◽

10.1093/oxfordjournals.jjco.a039777 ◽

1995 ◽

Cited By ~ 1

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Environmental Factors ◽

Case Control Study ◽

Case Control ◽

Family History Of Cancer ◽

History Of ◽

Control Study ◽

History Of Cancer

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Maternal interview reports of family history of birth defects: Evaluation from a population-based case-control study of orofacial clefts

American Journal of Medical Genetics ◽

10.1002/(sici)1096-8628(19971112)72:4<422::aid-ajmg10>3.0.co;2-t ◽

1997 ◽

Vol 72 (4) ◽

pp. 422-429 ◽

Cited By ~ 3

Author(s):

Paul A. Romitti ◽

Trudy L. Burns ◽

Jeffrey C. Murray

Keyword(s):

Family History ◽

Birth Defects ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Orofacial Clefts ◽

History Of ◽

Control Study

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346. Factors Associated with Hypertension in Young Adults with Perinatally-Acquired HIV Infection: a Case–Control Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.419 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S184-S184

Author(s):

Patrick O’Neil ◽

Patrick Ryscavage ◽

Kristen A Stafford

Keyword(s):

Risk Factors ◽

Young Adults ◽

Family History ◽

Case Control Study ◽

Case Control ◽

Systemic Hypertension ◽

Early Management ◽

Factors Associated ◽

History Of ◽

Control Study

Abstract Background The incidence of systemic hypertension (HTN) among perinatally-HIV-infected (PHIV) patients appears to increase as they enter adulthood. Among non-perinatally HIV-infected adults both traditional and HIV-associated risk factors have been found to contribute to HTN. Whether these same factors contribute to HTN in PHIV is unknown. The purpose of this study was to determine the socio-demographic, clinical, virologic, and immunologic factors associated with HTN among a cohort of PHIV adolescents and young adults, aged ≥18 years. Methods We conducted a case–control study among a population of 160 PHIV adults with and without HTN who were receiving care at the University of Maryland and aged 18–35 years as of December 31, 2017. Covariates assessed included traditional risk factors such as age, family history of HTN, and smoking, as well as HIV- and antiretroviral-associated covariates. Results We identified 49 HTN cases (30.6%) and 111 (69.4%) controls. There were no significant differences in the odds of most traditional (age, gender, race, family history of HTN, tobacco, alcohol, and/or other drug use) or HIV-associated (CD4 nadir <100 cells/mm3, individual ART exposure, ART interruption) risk factors among PHIV adults with HTN compared with those with no diagnosis of HTN. Cases had lower odds of a history of treatment with lopinavir/ritonavir (LPV/r). Cases had 3.7 (95% CI 1.11, 12.56) times the odds of a prior diagnosis of chronic kidney disease (CKD) compared with controls after controlling for CD4 nadir and ARV treatment history. Conclusion The results of this study suggest that most traditional and HIV-related risk factors do not appear to increase the odds of having HTN in this PHIV cohort. However, HTN among PHIV may be driven in part by CKD, and a focus on the prevention and early management of CKD in this group may be necessary to prevent the development of HTN. Additionally, there may be as yet unidentified risk factors for HTN among PHIV which require further exploration. Given the large and growing population of PHIV entering adulthood worldwide, it is imperative to explore risk factors for and effects of HTN in large, diverse PHIV populations. Disclosures All authors: No reported disclosures.

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