Berberine attenuates oxidative stress and hepatocytes apoptosis via protecting mitochondria in blunt snout bream Megalobrama amblycephala fed high-fat diets

2016 ◽  
Vol 43 (1) ◽  
pp. 65-76 ◽  
Author(s):  
Kang-Le Lu ◽  
Li-Na Wang ◽  
Ding-Dong Zhang ◽  
Wen-Bin Liu ◽  
Wei-Na Xu
Keyword(s):  
Oxidative Stress ◽  
Megalobrama Amblycephala ◽  
High Fat ◽  
Blunt Snout Bream ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals High-fat-diet-induced inflammation depresses the appetite of blunt snout bream (Megalobrama amblycephala) through the transcriptional regulation of leptin/mammalian target of rapamycin

2018 ◽  
Vol 120 (12) ◽  
pp. 1422-1431 ◽  
Author(s):  
Yong-Jun Dai ◽  
Guang-Zhen Jiang ◽  
Xiang-Yang Yuan ◽  
Wen-Bin Liu
Keyword(s):  
Food Intake ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Inflammatory Factors ◽  
Megalobrama Amblycephala ◽  
High Fat ◽  
Blunt Snout Bream ◽  
Appetite Suppression ◽  
High Fat Diets ◽  
Fat Diets

AbstractThe aim of this article was to investigate the mechanism of appetite suppression induced by high-fat diets (HFD) in blunt snout bream (Megalobrama amblycephala). Fish (average initial weight 40·0 (sem 0·35) g) were fed diets with two fat levels (6 and 11 %) with four replicates. HFD feeding for 30 d could significantly increase the weight gain rate, but feeding for 60 d cannot. Food intake of M. amblycephala began to decline significantly in fish fed the HFD for 48 d. HFD feeding for 60 d significantly reduced the expression of neuropeptide Y and elevated the expression of cocaine- and amphetamine-regulated transcript (CART), actions both in favour of suppression of appetite. The activation of fatty acid sensing was partly responsible for the weakened appetite. In addition, inflammatory factors induced by the HFD may be involved in the regulation of appetite by increasing the secretion of leptin and then activating the mammalian target of rapamycin (mTOR). Lipopolysaccharide (LPS, 2·0 mg/kg of fish weight) was administered to induce inflammation, and sampling was performed after 3, 6, 9, 12, 18, 24 and 48 h of LPS injection. Within 6–24 h of LPS injection, the food intake and appetite of M. amblycephala decreased significantly, whereas the mRNA expression of leptin and mTOR increased significantly. Our results indicate that inflammatory cytokines may be the cause of appetite suppression in M. amblycephala fed a HFD.

Alterations of liver histology and blood biochemistry in blunt snout bream Megalobrama amblycephala fed high-fat diets

2013 ◽  
Vol 79 (4) ◽  
pp. 661-671 ◽  
Author(s):  
Kang-le Lu ◽  
Wei-na Xu ◽  
Jun-yi Li ◽  
Xiang-fei Li ◽  
Guo-qing Huang ◽  
...  
Keyword(s):  
Blood Biochemistry ◽  
Liver Histology ◽  
Megalobrama Amblycephala ◽  
High Fat ◽  
Blunt Snout Bream ◽  
High Fat Diets ◽  
Fat Diets

Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets

2009 ◽  
Vol 47 (6) ◽  
pp. 1362-1367 ◽  
Author(s):  
K.K.R. Rocha ◽  
G.A. Souza ◽  
G.X. Ebaid ◽  
F.R.F. Seiva ◽  
A.C. Cataneo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
High Fat ◽  
Hepatic Oxidative Stress ◽  
High Fat Diets ◽  
Fat Diets ◽  
Toxicity Effects

The combination of maternal and offspring high-fat diets causes marked oxidative stress and development of metabolic syndrome in mouse offspring

Life Sciences ◽  
2016 ◽  
Vol 151 ◽  
pp. 70-75 ◽  
Author(s):  
Junya Ito ◽  
Kiyotaka Nakagawa ◽  
Shunji Kato ◽  
Taiki Miyazawa ◽  
Fumiko Kimura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

Changing the paradigm for myoglobin: a novel link between lipids and myoglobin

2014 ◽  
Vol 117 (3) ◽  
pp. 307-315 ◽  
Author(s):  
Amber E. Schlater ◽  
Michael A. De Miranda ◽  
Melinda A. Frye ◽  
Stephen J. Trumble ◽  
Shane B. Kanatous
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Tissue Sample ◽  
Oxidative Stress Marker ◽  
Oxygen Binding ◽  
High Fat ◽  
Western Blots ◽  
High Fat Diets ◽  
Lipid Supplementation ◽  
Fat Diets

Myoglobin (Mb) is an oxygen-binding muscular hemeprotein regulated via Ca2+-signaling pathways involving calcineurin (CN), with Mb increases attributed to hypoxia, exercise, and nitric oxide. Here, we show a link between lipid supplementation and increased Mb in skeletal muscle. C2C12 cells were cultured in normoxia or hypoxia with glucose or 5% lipid. Mb assays revealed that lipid cohorts had higher Mb than control cohorts in both normoxia and hypoxia, whereas Mb Western blots showed lipid cohorts having higher Mb than control cohorts exclusively under hypoxia. Normoxic cells were compared with soleus tissue from normoxic rats fed high-fat diets; whereas tissue sample cohorts showed no difference in CO-binding Mb, fat-fed rats showed increases in total Mb protein (similar to hypoxic cells), suggesting increases in modified Mb. Moreover, Mb increases did not parallel CN increases but did, however, parallel oxidative stress marker augmentation. Addition of antioxidant prevented Mb increases in lipid-supplemented normoxic cells and mitigated Mb increases in lipid-supplemented hypoxic cells, suggesting a pathway for Mb regulation through redox signaling independent of CN.

The interconnection of high-fat diets, oxidative stress, the heart, and carcinogenesis

Cancer ◽  
2021 ◽  
pp. 111-120
Author(s):  
Bianka Bojková ◽  
Natalia Kurhaluk ◽  
Pawel J. Winklewski
Keyword(s):  
Oxidative Stress ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals The Combination of Mulberry Extracts and Silk Amino Acids Alleviated High Fat Diet-Induced Nonalcoholic Hepatic Steatosis by Improving Hepatic Insulin Signaling and Normalizing Gut Microbiome Dysbiosis in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Sunmin Park ◽  
Ting Zhang ◽  
Jing Yi Qiu ◽  
Xuangao Wu
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Disease Control ◽  
Normal Control ◽  
Insulin Signaling ◽  
High Fat ◽  
Hepatic Insulin Signaling ◽  
High Fat Diets ◽  
Fat Diets ◽  
Better Than

Mulberry water extracts (MB) and silk amino acids (SA) are reported to improve oxidative stress and inflammation, respectively. We hypothesized whether the mixture of mulberry water extracts and silk amino acids can alleviate nonalcoholic fatty liver disease (NAFLD) induced by high fat diets. Male Sprague Dawley rats were orally provided with high fat diets containing different ratios of MB and SA (1:3, MS1:3, or 1:5, MS1:5) or cellulose (the disease-control) for 12 weeks. Rats had 200 or 600 mg/kg bw of MS1:3 and MS1:5 (MS1:3-L, MS1:3-H; MS1:5-L, and MS1:5-H). Rats in the normal-control group were fed the 20% fat diet with cellulose. Disease-control rats exhibited much greater triglyceride (TG) deposition in the liver than the normal-control rats along with increased body weight gain, visceral fat mass, serum concentrations of cholesterol, triglyceride and nonesterified fatty acid (NEFA), and insulin resistance. Disease-control rats also had liver damage with increased oxidative stress and inflammation compared to the normal-control rats. MS1:3-H and MS1:5-H were found to have greater hepatic glycogen accumulation and decreased hepatic TG, insulin resistance, and dyslipidemia, with MS1:5-H being similar to the normal-control. MS1:3-H alleviated oxidative stress with lower hepatic lipid peroxide compared to MS1:5-H whereas MS1:5-H ameliorated inflammation and hepatocyte damage better than MS1:3-H. Both MS1:3-H and MS1:5-H potentiated hepatic insulin signaling (pAkt⟶pACC) and reduced the mRNA expression of TG synthesis genes mRNA (FAS and SREBP-1c). In the gut microbiome MS1:3-H elevated the ratio of Bacteroidales to Clostridiales in the cecum better than MS1:5-H but MS1:5-H reduced the proinflammatory Turicibacterales. In conclusion, both MS1:3-H and MS1:5-H prevented liver damage induced by high fat diets, mainly by suppressing oxidative stress and inflammation, respectively. MS1:3 and MS1:5 might be used as therapeutic agent for NAFLD.

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