Changes in the glycolipid composition and characteristic activation of GM3 synthase in the thymus of mouse after administration of dexamethasone

2005 ◽  
Vol 22 (3) ◽  
pp. 119-126 ◽  
Author(s):  
Masao Iwamori ◽  
Yuriko Iwamori
Keyword(s):  
Gm3 Synthase ◽  
Glycolipid Composition

scholarly journals Curcumin Downregulates Human GM3 Synthase (hST3Gal V) Gene Expression with Autophagy Induction in Human Colon Carcinoma HCT116 Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Miri Lee ◽  
Hyunju Choi ◽  
Kyoung-Sook Kim ◽  
Dong-Hyun Kim ◽  
Cheorl-Ho Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Luciferase Reporter ◽  
Gm3 Synthase ◽  
Human Colon Carcinoma ◽  
Autophagy Induction ◽  
Promoter Deletion Analysis ◽  
V Gene ◽  
Hct116 Cells

Our recent report showed that curcumin, polyphenolic compound isolated from the herb Curcuma longa, upregulated the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis with autophagy induction in human lung adenocarcinoma A549 cells. In this study, on the contrary to this finding, we demonstrated that curcumin downregulated the gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 synthesis with autophagy induction in human colon carcinoma HCT116 cells. To clarify the mechanism leading to the downregulation of hST3Gal V gene expression in curcumin-treated HCT116 cells, we analyzed the curcumin-inducible promoter of the hST3Gal V gene by luciferase reporter assays. Promoter deletion analysis demonstrated that the -177 to -83 region, which includes putative binding sites for transcription factors NFY, CREB/ATF, SP1, EGR3, and MZF1, acts as the curcumin-responsive promoter of the hST3Gal V gene. Site-directed mutagenesis and chromatin immunoprecipitation analysis demonstrated that the CREB/ATF binding site at -143 is pivotal for curcumin-induced downregulation of hST3Gal V gene in HCT116 cells. The transcriptional activation of hST3Gal V in HCT116 cells was significantly repressed by an inhibitor of AMP-activated protein kinase (AMPK). These results suggest that AMPK signal pathway mediates hST3Gal V gene expression in HCT116 cells.

MALDI-TOF mass spectrometry as a simple tool to determine the phospholipid/glycolipid composition of sperm: Pheasant spermatozoa as one selected example

2011 ◽  
Vol 123 (3-4) ◽  
pp. 270-278 ◽  
Author(s):  
Kristin Teuber ◽  
Jürgen Schiller ◽  
Ulrike Jakop ◽  
Stefan Lüpold ◽  
Josephine M. Orledge ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof ◽  
Simple Tool ◽  
Glycolipid Composition

Comparative analysis of glycoprotein and glycolipid composition of virulent and avirulent strain membranes ofMycoplasma hyopneumoniae

1992 ◽  
Vol 24 (4) ◽  
pp. 189-192 ◽  
Author(s):  
Jian Wen Chen ◽  
Lanping Zhang ◽  
Jiantao Song ◽  
Fen Hwang ◽  
Qinghua Dong ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Avirulent Strain ◽  
Glycolipid Composition

scholarly journals Serum Deprivation-Induced Human GM3 Synthase (hST3Gal V) Gene Expression Is Mediated by Runx2 in Human Osteoblastic MG-63 Cells

2015 ◽  
Vol 17 (1) ◽  
pp. 35 ◽  
Author(s):  
Hyun-Kyoung Yoon ◽  
Ji-Won Lee ◽  
Kyoung-Sook Kim ◽  
Seo-Won Mun ◽  
Dong-Hyun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Serum Deprivation ◽  
Gm3 Synthase ◽  
V Gene

Synthesis and Biological Evaluation of Several Dephosphonated Analogues of CMP-Neu5Ac as Inhibitors of GM3-Synthase

2015 ◽  
Vol 21 (41) ◽  
pp. 14614-14629 ◽  
Author(s):  
Paola Rota ◽  
Federica Cirillo ◽  
Marco Piccoli ◽  
Antonio Gregorio ◽  
Guido Tettamanti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Gm3 Synthase ◽  
Synthesis And Biological Evaluation

Glycolipid Composition of Ascitic Fluids from Patients with Cancer1

1984 ◽  
Vol 96 (4) ◽  
pp. 1257-1265 ◽  
Author(s):  
Takao TAKI ◽  
Yasuo KOJIMA ◽  
Hiroyuki SETO ◽  
Hideo YAMADA ◽  
Makoto MATSUMOTO
Keyword(s):  
Glycolipid Composition
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