Adipose Tissue Inflammation and Oxidative Stress: the Ameliorative Effects of Vitamin D

Inflammation ◽  
2017 ◽  
Vol 40 (5) ◽  
pp. 1688-1697 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mehran Mesgari-Abbasi ◽  
Ghazaleh Hajiluian ◽  
Ghazaleh Nameni ◽  
Parviz Shahabi
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
And Oxidative Stress

Insulin Sensitizing Effects of Vitamin D Mediated through Reduced Adipose Tissue Inflammation and Fibrosis

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 39-OR
Author(s):  
ERIC LONTCHI-YIMAGOU ◽  
SONA KANG ◽  
KEHAO ZHANG ◽  
AKANKASHA GOYAL ◽  
JEE YOUNG YOU ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

Vitamin D restriction enhances periovarian adipose tissue inflammation in a model of menopause

Climacteric ◽  
2019 ◽  
Vol 23 (1) ◽  
pp. 99-104 ◽  
Author(s):  
C. C. Borges ◽  
I. Bringhenti ◽  
M. B. Aguila ◽  
C. A. Mandarim-de-Lacerda
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

scholarly journals Indoxyl Sulfate Contributes to Adipose Tissue Inflammation through the Activation of NADPH Oxidase

Toxins ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 502
Author(s):  
Shoma Tanaka ◽  
Hiroshi Watanabe ◽  
Takehiro Nakano ◽  
Tadashi Imafuku ◽  
Hiromasa Kato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Nadph Oxidase ◽  
Organic Anion ◽  
Indoxyl Sulfate ◽  
Epididymal Adipose Tissue ◽  
Ros Production ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Anion Transporter

Adipose tissue inflammation appears to be a risk factor for the progression of chronic kidney disease (CKD), but the effect of CKD on adipose tissue inflammation is poorly understood. The purpose of this study was to clarify the involvement of uremic toxins (indoxyl sulfate (IS), 3-indoleacetic acid, p-cresyl sulfate and kynurenic acid) on CKD-induced adipose tissue inflammation. IS induces monocyte chemoattractant protein-1 (MCP-1) expression and reactive oxygen species (ROS) production in the differentiated 3T3L-1 adipocyte. An organic anion transporter (OAT) inhibitor, an NADPH oxidase inhibitor or an antioxidant suppresses the IS-induced MCP-1 expression and ROS production, suggesting the OAT/NADPH oxidase/ROS pathway is involved in the action of IS. Co-culturing 3T3L-1 adipocytes and mouse macrophage cells showed incubating adipocytes with IS increased macrophage infiltration. An IS-overload in healthy mice increased IS levels, oxidative stress and MCP-1 expression in epididymal adipose tissue compared to unloaded mice. Using 5/6-nephrectomized mice, the administration of AST-120 suppressed oxidative stress and the expression of MCP-1, F4/80 and TNF-α in epididymal adipose tissue. These collective data suggest IS could be a therapeutic target for the CKD-related inflammatory response in adipose tissue, and that AST-120 could be useful for the treatment of IS-induced adipose tissue inflammation.

scholarly journals Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 342 ◽  
Author(s):  
Alexandra Marziou ◽  
Clothilde Philouze ◽  
Charlène Couturier ◽  
Julien Astier ◽  
Philippe Obert ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
De Novo ◽  
De Novo Lipogenesis ◽  
Acid Oxidation ◽  
Mrna Levels ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Triglyceride Accumulation

The beneficial effect of vitamin D (VD) supplementation on body weight gain limitation and inflammation has been highlighted in primary prevention mice models, but the long-term effect of VD supplementation in tertiary prevention has never been reported in obesity models. The curative effect of VD supplementation on obesity and associated disorders was evaluated in high-fat- and high-sucrose (HFS)-fed mice. Morphological, histological, and molecular phenotype were characterized. The increased body mass and adiposity caused by HFS diet as well as fat cell hypertrophy and glucose homeostasis were not improved by VD supplementation. However, VD supplementation led to a decrease of HFS-induced inflammation in inguinal adipose tissue, characterized by a decreased expression of chemokine mRNA levels. Moreover, a protective effect of VD on HFS-induced hepatic steatosis was highlighted by a decrease of lipid droplets and a reduction of triglyceride accumulation in the liver. This result was associated with a significant decrease of gene expression coding for key enzymes involved in hepatic de novo lipogenesis and fatty acid oxidation. Altogether, our results show that VD supplementation could be of interest to blunt the adipose tissue inflammation and hepatic steatosis and could represent an interesting nutritional strategy to fight obesity-associated comorbidities.

scholarly journals Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice

2019 ◽  
Vol 1865 (6) ◽  
pp. 1567-1578 ◽  
Author(s):  
Daniel Jahn ◽  
Donata Dorbath ◽  
Anne-Kristin Schilling ◽  
Lisa Gildein ◽  
Chantal Meier ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Vitamin D Receptor ◽  
Liver Steatosis ◽  
Adipose Tissue Inflammation ◽  
Obese Mice ◽  
Tissue Inflammation

Role of the intestinal vitamin D receptor in obesity, adipose tissue inflammation and hepatic lipid accumulation

2017 ◽  
Vol 66 (1) ◽  
pp. S168
Author(s):  
D. Jahn ◽  
D. Dorbath ◽  
A.-K. Schilling ◽  
L. Gildein ◽  
J. Schmitt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Vitamin D Receptor ◽  
Lipid Accumulation ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

scholarly journals Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis

2017 ◽  
Vol 58 (9) ◽  
pp. 1797-1807 ◽  
Author(s):  
Patricia Chimin ◽  
Maynara L. Andrade ◽  
Thiago Belchior ◽  
Vivian A. Paschoal ◽  
Juliana Magdalon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Nlrp3 Inflammasome ◽  
De Novo ◽  
Inflammasome Activation ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Nlrp3 Inflammasome Activation ◽  
Ceramide Synthesis
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